Abstract:
:Homoprolinol analogs, a class of optically active γ-amino alcohols, were examined systematically in the enantioselective addition reactions of diethylzinc to aldehydes. By comparison of the results catalyzed by these γ-amino alcohols with those by the β-amino alcohols based on pyrrolidine architecture reported in the literature references, we have observed that the γ-amino alcohols are superior to the corresponding β-amino alcohols when the nitrogen and the oxygen are unsubstituted. Among the homoprolinols we tested, gave the best results (45-88% yields, 44-81% ee) in the addition reactions. To the best of our knowledge, has been noticed as one of the most efficient γ-amino alcohol catalysts based on pyrrolidine framework.
journal_name
Chiralityjournal_title
Chiralityauthors
Liu CL,Wei CY,Wang SW,Peng YGdoi
10.1002/chir.21017subject
Has Abstractpub_date
2011-11-01 00:00:00pages
921-8issue
10eissn
0899-0042issn
1520-636Xjournal_volume
23pub_type
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