Conformational and Chiral Properties of Cyclic-tri(N-methyl-meta-benzamide) Bearing Amidino Groups.

abstract：:In this review, the recently reported approaches for the preparation of cyclodextrin-functionalized capillary monolithic columns are highlighted, with few applications in chiral separations using capillary liquid chromatography (CLC) and capillary electrochromatography (CEC). Chirality 28:97-109, 2016. © 2015 Wiley Pe...

journal_title：Chirality

authors： Adly FG,Antwi NY,Ghanem A

更新日期：2016-02-01 00:00:00

abstract：:We introduce a method to detect the activity of ion channels and pores with circular dichroism (CD) spectroscopy. G-quartets obtained by potassium templated self-assembly of 5'-guanosine monophosphate (GMP) are used as CD probes, the bee-toxin melittin as representative pore and gramicidin A as representative ion chan...

journal_title：Chirality

authors： Hennig A,Matile S

更新日期：2008-09-01 00:00:00

abstract：:This work presents results of methyl 7-oxoabiet-13(14)-en-18-oate (3) self-oxidation with air-oxygen in the presence of various bases such as triethylamine or sodium t-butoxide. While under aerobic conditions, the use of sodium t-butoxide as a base results in the formation of four isomeric alcohols, an addition of tri...

journal_title：Chirality

authors： Masnyk M,Kuśmirek D,Trzybiński D,Frelek J

更新日期：2020-04-01 00:00:00

abstract：:Spontaneous symmetry breaking in reactive systems, known as a rare physical phenomenon and for the Soai autocatalytic irreversible reaction, might in principle also occur in other, more common asymmetric reactions when the chiral product is capable to promote its formation and an element of "nonlinearity" is involved ...

journal_title：Chirality

authors： Mauksch M,Tsogoeva SB,Wei S,Martynova IM

更新日期：2007-11-01 00:00:00

abstract：:The synthesis of the eight stereoisomers of muscarine has been efficiently accomplished by utilizing the two enantiomers of lactic esters as starting material. The synthetic strategy is based on a SnCl4-catalyzed addition of allyltrimethylsilane to O-protected lactic aldehydes followed by an iodocyclization process. A...

journal_title：Chirality

authors： De Amici M,Dallanoce C,De Micheli C,Grana E,Dondi G,Ladinsky H,Schiavi G,Zonta F

更新日期：1992-01-01 00:00:00

abstract：:The chiral fungicide furametpyr is widely used in the rice field to control rice sheath blight; however, furametpyr enantiomers are treated as just one compound in traditional achiral analysis, which gives only partial information. An effective chiral analytical method was developed for the resolution and determinatio...

journal_title：Chirality

authors： Dong F,Chen X,Xu J,Liu X,Chen Z,Li Y,Zhang H,Zheng Y

更新日期：2013-12-01 00:00:00

abstract：:The special relationship between France and the polarization of light from the beginning of the 19th century until the present day is reviewed in the lives and works of Étienne Louis Malus, François Arago, Jean-Baptiste Biot, Augustin Fresnel, Louis Pasteur, Frédéric Wallerant, Aimé Cotton, Francis Perrin, and Alain A...

journal_title：Chirality

authors： Kahr B

更新日期：2018-04-01 00:00:00

abstract：:Experimental studies suggest that amide bond may significantly deviate from planar arrangement even in linear peptides and proteins. In order to find out the extent to which such deviation may influence principal amide spectroscopic properties, we conducted a computational study of nonplanar N-methylacetamide (NMA) co...

journal_title：Chirality

authors： Bednárová L,Malon P,Bour P

更新日期：2007-11-01 00:00:00

abstract：:This review brings together the past and current methods for synthesizing the classical cucurbit[n]uril (Q[n]), structural variants, and derivatives. Here we refer to the first family of Q[n] as " classical," where the cavity is spheroidal and carry no substituents at any of the equatorial methine carbons or the methy...

journal_title：Chirality

authors： Mandadapu V,Day AI,Ghanem A

更新日期：2014-11-01 00:00:00

abstract：:The elusive epimerization process in the chiral butenolide moiety of Annonaceous acetogenins was examined under several sets of conditions commonly used for elimination leading to the alpha, beta-unsaturated lactone and the results provide practical guidance in choosing elimination conditions. ...

journal_title：Chirality

authors： Yu Q,Wu Y,Wu YL,Xia LJ,Tang MH

更新日期：2000-03-01 00:00:00

abstract：:Diastereomeric reduction of nonactivated, hindered β-keto and chiral β-iminoesters are described. The influence of a α-stereocontrolled center on the efficiency and stereoselectivity of the reduction was studied. Reaction conditions were optimized to synthesize β-hydroxy- and β-aminoesters in good yields. In the case ...

journal_title：Chirality

authors： Almahli H,Hendra F,Troufflard C,Cavé C,Joseph D,Delarue-Cochin S

更新日期：2011-03-01 00:00:00

abstract：:Herein we report CD spectroscopic studies on complexes of (R,R)-dimethyl-, (R,R)-diisobutyl-, and (S,S)-di-sec-butyl-phenazino-18-crown-6 ligands (Scheme 1) with selected alkali (Na+, K+), alkaline earth (Mg2+, Ca2+), and transition-metal (Ag+, Zn2+, Ni2+, Cd2+, Pb2+) cations. The complexation was monitored in the 300...

journal_title：Chirality

authors： Szarvas S,Szalay L,Vass E,Hollósi M,Samu E,Huszthy P

更新日期：2005-06-01 00:00:00

abstract：:The versatility of a previously developed method for the synthesis of chiral carbene-based palladacycles is demonstrated through the synthesis of two new chiral pyridine-functionalized N-heterocyclic carbene palladacycles with different wingtip groups. The efficiency in their resolution with different counter anions a...

journal_title：Chirality

authors： Ng KH,Li Y,Tan WX,Chiang M,Pullarkat SA

更新日期：2013-03-01 00:00:00

abstract：:In modern chromatography, chiral stationary phase (CSP) and enantiomer self-disproportionation (ESD) are new inventions of packing material offer a guarantee for a successful enantiomeric separation. All CSPs were synthesized by chemical bonding of the relevant organic moieties onto a porous parent silica material for...

journal_title：Chirality

authors： Mayani VJ,Abdi SH,Mayani SV,Kim HC,Park SK

更新日期：2011-04-01 00:00:00

abstract：:Compound A, a novel disubstituted pyrrolidine acid, is a member of a new class of agents that are potentially useful for the treatment of diabetes and dyslipidemia. The absolute configuration of this compound was determined by using vibrational circular dichroism (VCD). The results are in agreement with the assignment...

journal_title：Chirality

authors： Freedman TB,Cao X,Phillips LM,Cheng PT,Dalterio R,Shu YZ,Zhang H,Zhao N,Shukla RB,Tymiak A,Gozo SK,Nafie LA,Gougoutas JZ

更新日期：2006-09-01 00:00:00

abstract：:A Micelle-enhanced ultrafiltration (MEUF) separation process was investigated that can potentially be used for large-scale enantioseparations. Copper(II)-amino acid derivatives dissolved in nonionic surfactant micelles were used as chiral selectors for the separation of dilute racemic amino acids solutions. For the al...

journal_title：Chirality

authors： De Bruin TJ,Marcelis AT,Zuilhof H,Rodenburg LM,Niederländer HA,Koudijs A,Overdevest PE,Van der Padt A,Sudhölter EJ

更新日期：2000-08-01 00:00:00

abstract：:According to the Ibuprofen Product-Specific Bioequivalence Guidance of the European Medicines Agency, achiral bioanalytical methods are considered acceptable for demonstration of bioequivalence of ibuprofen-containing products. The aim of this investigation is to compare the bioequivalence outcomes obtained with indiv...

journal_title：Chirality

authors： González-Rojano E,Marcotegui J,Laredo L,Gwaza L,Gordon J,Portolés A,Vargas E,Morales-Alcelay S,García-Arieta A

更新日期：2020-09-01 00:00:00

abstract：:Studies on the interactions between L-O- phosphoserine, as one of the simplest fragments of membrane components, and the Cinchona alkaloid cinchonine, in the crystalline state were performed. Cinchoninium L-O-phosposerine salt dihydrate (PhSerCin) crystallizes in a monoclinic crystal system, space group P2(1), with un...

journal_title：Chirality

authors： Wesełucha-Birczyńska A,Oleksyn BJ,Watroba J

更新日期：2010-06-01 00:00:00

abstract：:New chiral derivatizing reagents (CDAs) derived from trans-1,2-diaminocyclohexane, having an electron-deficient aromatic substituent (either an aromatic imide or 3,5-dinitrobenzamide) and rigid structure (either an amide or a urea linker), are reported. Significant shift differences of diastereotopic protons in the 1H...

journal_title：Chirality

authors： Kaik M,Gajewy J,Grajewski J,Gawronski J

更新日期：2008-03-01 00:00:00

abstract：:6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) enantiomers were separated by supercritical fluid extraction using carbon dioxide. Diastereoisomeric salts were formed from the racemic base with less than one equivalent of O,O'-di-(4-toluoyl)-(2R,3R)-tartaric acid (DPTTA). Further purification was achieved by part...

journal_title：Chirality

authors： Kmecz I,Simándi B,Bálint J,Székely E,Fogassy E,Kemény S

更新日期：2001-01-01 00:00:00

abstract：:The use of four cyclodextrins (three native and one beta-CD derivative) as NMR chiral solvating agents to resolve the enantiomers of (+/-)-cizolirtine, 1, and its chemical precursor (the carbinol, (+/-)-2), was investigated. The best enantiodiscrimination occurred when beta-cyclodextrin was used. ROESY experiments wer...

journal_title：Chirality

authors： Redondo J,Blázquez MA,Torrens A

更新日期：1999-01-01 00:00:00

abstract：:Caffeic acid-derived polyethers are a class of natural products isolated from the root extracts of comfrey and bugloss, which are endowed with intriguing pharmacological properties as anticancer agents. The synthesis of new polyether derivatives is achieved through ring-opening polymerization of chiral 2,3-disubstitut...

journal_title：Chirality

authors： Tedesco D,Fabini E,Barbakadze V,Merlani M,Zanasi R,Chankvetadze B,Bertucci C

更新日期：2015-12-01 00:00:00

abstract：:Despite that a number of experimental and theoretical investigations have been carried out to determine the structure of trialanine in water, the reported populations of polyproline II (PPII) and β-strand conformers vary and were found to be dependent on which spectroscopic method was used. Such discrepancies are due ...

journal_title：Chirality

authors： Oh KI,Lee KK,Park EK,Yoo DG,Hwang GS,Cho M

更新日期：2010-01-01 00:00:00

abstract：:The direct Michael addition reaction of cyclohexanone/aliphatic aldehydes with nitroolefins, catalyzed by a novel chiral pyrrolidine-thiourea catalyst 1a, is described. The desired 1,4-adducts were obtained in moderate yields with enantioselectivities up to 99% ee and dr up to 99:1 of the syn product. ...

journal_title：Chirality

authors： Shen Z,Zhang Y,Jiao C,Li B,Ding J,Zhang Y

更新日期：2007-05-05 00:00:00

abstract：:A three-dimensional molecularly imprinted overoxidized polypyrrole/MnO2 /carbon felt (MIOPPy/MnO2 /CF) composites were fabricated, which results in increased active area of the surface of the molecularly imprinted polymers film and greatly improved electrochemical chiral recognition effect for tryptophan isomers. The ...

journal_title：Chirality

authors： Dong L,Liu X,Xu H,Wu D,Gao S,Zhong L,Kong Y

更新日期：2019-11-01 00:00:00

abstract：:The modern use of preparative chromatography in pharmaceutical development is illustrated by the case of a recent preclinical candidate from these laboratories. The synthesis of the candidate employed a coupling of two enantiopure intermediates, each of which could be resolved using preparative chiral chromatography. ...

journal_title：Chirality

authors： Leonard WR Jr,Henderson DW,Miller RA,Spencer GA,Sudah OS,Biba M,Welch CJ

更新日期：2007-09-01 00:00:00

abstract：:The absolute configuration of the acyclic side chain of heptopyranosides and heptofuranosides was determined by exciton coupled CD, employing the strongly fluorescent 2-anthroate chromophore. The usage of this chromophore offers significant improvements over previous chemical and spectroscopic procedures since its int...

journal_title：Chirality

authors： Akritopoulou-Zanze I,Nakanishi K,Stepowska H,Grzeszczyk B,Zamojski A,Berova N

更新日期：1997-01-01 00:00:00

abstract：:Enantioseletive toxicities of chiral pesticides have become an environmental concern recently. In this study, we evaluated the enantiomeric separation of salithion on a suite of commercial chiral columns and assessed the toxicity of enantiomers toward butyrylcholinesterase and Daphnia magna. Satisfactory separations o...

journal_title：Chirality

authors： Zhou S,Lin K,Li L,Jin M,Ye J,Liu W

更新日期：2009-11-01 00:00:00

abstract：:This work reports confirmation of the experimental assignment of the absolute-handedness chirality of single-walled carbon nanotubes (SWNTs). This was achieved by applying the scanning tunneling microscopy (STM) imaging technique to a supramolecular composite consisting of a metalized porphyrin derivative (nickel-5,15...

journal_title：Chirality

authors： Abd El-Mageed AIA,Ogawa T

更新日期：2020-03-01 00:00:00

abstract：:(3SR,4RS)-3,4-Epoxypiperidine-4-carboxylic acid (isoguvacine oxide) is a potent and specific GABAA receptor agonist. Isoguvacine oxide, originally designed as a potentially alkylating agonist, turned out to interact with the GABAA receptor in a fully reversible manner. The protected form of isoguvacine oxide, benzyl (...

journal_title：Chirality

authors： Frølund B,Jeppesen L,Krogsgaard-Larsen P,Hansen JJ

更新日期：1995-01-01 00:00:00