Asymmetric reduction of β-ketoesters and chiral β-iminoesters: impact of a α-quaternary stereocenter.

Abstract:

:Diastereomeric reduction of nonactivated, hindered β-keto and chiral β-iminoesters are described. The influence of a α-stereocontrolled center on the efficiency and stereoselectivity of the reduction was studied. Reaction conditions were optimized to synthesize β-hydroxy- and β-aminoesters in good yields. In the case of chiral β-iminoesters, influence of matched/mismatched diastereomeric pairs has been assessed.

journal_name

Chirality

journal_title

Chirality

authors

Almahli H,Hendra F,Troufflard C,Cavé C,Joseph D,Delarue-Cochin S

doi

10.1002/chir.20909

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

265-71

issue

3

eissn

0899-0042

issn

1520-636X

journal_volume

23

pub_type

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