Abstract:
:Diastereomeric reduction of nonactivated, hindered β-keto and chiral β-iminoesters are described. The influence of a α-stereocontrolled center on the efficiency and stereoselectivity of the reduction was studied. Reaction conditions were optimized to synthesize β-hydroxy- and β-aminoesters in good yields. In the case of chiral β-iminoesters, influence of matched/mismatched diastereomeric pairs has been assessed.
journal_name
Chiralityjournal_title
Chiralityauthors
Almahli H,Hendra F,Troufflard C,Cavé C,Joseph D,Delarue-Cochin Sdoi
10.1002/chir.20909subject
Has Abstractpub_date
2011-03-01 00:00:00pages
265-71issue
3eissn
0899-0042issn
1520-636Xjournal_volume
23pub_type
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