Separation of amino acid enantiomers by micelle-enhanced ultrafiltration.

abstract：:Solid phase extraction (SPE)-chiral separation of the important drugs pheniramine, oxybutynin, cetirizine, and brinzolamide was achieved on the C18 cartridge and AmyCoat (150 x 46 mm) and Chiralpak AD (25 cm x 0.46 cm id) chiral columns in human plasma. Pheniramine, oxybutynin, cetirizine, and brinzolamide were resolv...

journal_title：Chirality

authors： Ali I,Al-Othman ZA,Al-Warthan A,Alam SD,Farooqi JA

更新日期：2014-03-01 00:00:00

abstract：:Kynurenic acid (KYNA), an endogenous antagonist of N-methyl-D-aspartate and α(7) nicotinic acetylcholine receptors, is one of the L-tryptophan (Trp) metabolites. To compare the level of KYNA produced in the striatum of rats after independent administration of L-Trp and D-Trp, rats were intraperitoneally administered L...

journal_title：Chirality

authors： Ishii K,Iizuka H,Ogaya T,Song Z,Fukushima T

更新日期：2011-01-01 00:00:00

abstract：:SCH 56592 is a novel triazole antifungal agent that is active both orally and intravenously in animal models of infection. This compound is in Phase II-III clinical trials for the treatment of systemic fungal infections. SCH 56592 is a single enantiomer with four stereogenic centers; therefore, it was necessary to eva...

journal_title：Chirality

authors： Kim H,Lin CC,Laughlin M,Lovey R,Saksena A,Heimark L,Nomeir AA

更新日期：2000-07-01 00:00:00

abstract：:The stability of Chiralpak AD chiral stationary phase under various solvent conditions was investigated. An analytical method for the detection of the presence of solubilized Chiralpak AD coating was developed using CD spectroscopy (CD signal at 245 nm). In addition, NMR analysis of the solubilized polymer revealed a ...

journal_title：Chirality

authors： Welch CJ,Fairchild J,Sajonz P

更新日期：2007-08-01 00:00:00

abstract：:Mirror symmetry breaking is ubiquitous in our visible universe taking place in elementary particles, atoms, and molecules. Molecular chirality is not biogenic in itself, although its detection is often considered a biosignature, a conjecture inferred from the fact that we do not know life devoid of homochirality. The ...

journal_title：Chirality

authors： Cintas P,Viedma C

更新日期：2012-11-01 00:00:00

abstract：:Kinetic and equilibrium binding studies were performed on the interaction of warfarin enantiomers with human serum albumin (HSA) in the absence and presence of lorazepam acetate (LoAc) enantiomers. Binding kinetics were followed by recording changes in the fluorescence of warfarin upon binding to HSA using the stopped...

journal_title：Chirality

authors： Fitos I,Visy J,Kardos J

更新日期：2002-05-15 00:00:00

abstract：:Origin(s) of biological chirality appear(s) to be intimately connected to origin(s) of life. Prebiotic evolution toward these important turning points can be traced back to single chiral molecules. These can be small (monomeric) units as amino acids or monosaccharides or oligomers as oligo-RNA type molecules. Earlier ...

journal_title：Chirality

authors： Caglioti L,Micskei K,Pályi G

更新日期：2011-01-01 00:00:00

abstract：:The electronic circular dichroism (ECD) spectra of two sesquiterpenoids (1 and 2) related to oplopanone, obtained from a methanolic extract of the plant Serphidium stenocephalum (Artemisia stenocephala), were measured and reproduced by means of time-dependent density functional theory (TDDFT) calculations, establishin...

journal_title：Chirality

authors： Shafiq N,Saleem M,Riaz N,Tousif MI,Jabbar A,Tareen RB,Pescitelli G

更新日期：2014-01-01 00:00:00

abstract：:Previously, a diazaphospholidine has been synthesized and evaluated as a chiral derivatizing reagent for the determination of the optical purity of chiral alcohols via 31P NMR spectroscopy (Alexakis et al., J. Org. Chem. 57:1224-1237, 1992). Our laboratory is interested in the advantageous and practical applications o...

journal_title：Chirality

authors： House KL,O'Connor MJ,Silks LA 3rd,Dunlap RB,Odom JD

更新日期：1994-01-01 00:00:00

abstract：:According to the Ibuprofen Product-Specific Bioequivalence Guidance of the European Medicines Agency, achiral bioanalytical methods are considered acceptable for demonstration of bioequivalence of ibuprofen-containing products. The aim of this investigation is to compare the bioequivalence outcomes obtained with indiv...

journal_title：Chirality

authors： González-Rojano E,Marcotegui J,Laredo L,Gwaza L,Gordon J,Portolés A,Vargas E,Morales-Alcelay S,García-Arieta A

更新日期：2020-09-01 00:00:00

abstract：:Doping nematic liquid crystals with nonracemic chiral compounds induces a twisted nematic (cholesteric) phase. The ability of solutes to twist the nematic phase may be related to the overall shape of the chiral dopant and consequently to its absolute configuration. The cholesteric induction is therefore a powerful too...

journal_title：Chirality

authors： Pieraccini S,Ferrarini A,Spada GP

更新日期：2008-05-15 00:00:00

abstract：:Enantioseletive toxicities of chiral pesticides have become an environmental concern recently. In this study, we evaluated the enantiomeric separation of salithion on a suite of commercial chiral columns and assessed the toxicity of enantiomers toward butyrylcholinesterase and Daphnia magna. Satisfactory separations o...

journal_title：Chirality

authors： Zhou S,Lin K,Li L,Jin M,Ye J,Liu W

更新日期：2009-11-01 00:00:00

abstract：:Perfluorooctane sulfonate (PFOS) is one of the most frequently detected perfluoroalkyl substances in environmental and human samples. Previous studies have shown that nonracemic PFOS in biological samples can be used as a marker of PFOS exposure sources. In recent years, supercritical fluid chromatography (SFC) has em...

journal_title：Chirality

authors： Zhao L,Chen F,Guo F,Liu W,Liu K

更新日期：2019-10-01 00:00:00

abstract：:The possibility that enantiodiscrimination of bilirubin might be involved in neuronal membrane destabilization, and therefore in bilirubin toxicity, was investigated, by circular dichroism, on model membranes composed of phospholipids. The equilibrium between bilirubin enantiomers is displaced at some extent by the in...

journal_title：Chirality

authors： Bernardini C,D'Arrigo P,Elemento G,Mancini G,Servi S,Sorrenti A

更新日期：2009-01-01 00:00:00

abstract：:The pharmacokinetics of (-)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine (nateglinide) and its enantiomer (L-enantiomer) was studied in Goto-Kakizaki (GK) rats after intravenous administration of nateglinide or L-enantiomer at a dose of 40 micromol/kg body weight. Nateglinide, its L-enantiomer and their me...

journal_title：Chirality

authors： Tamura M,Shiba S,Kudo N,Kawashima Y

更新日期：2010-01-01 00:00:00

abstract：:The adsorption of heptahelicene, a helically shaped polyaromatic hydrocarbon (C(30)H(18)), on a Cu(111) surface was studied by means of thermal desorption mass spectrometry (TDMS) and low energy electron diffraction (LEED) at temperatures between 130-1,000 K under ultrahigh vacuum (UHV) conditions. The molecule in the...

journal_title：Chirality

authors： Ernst KH,Kuster Y,Fasel R,Müller M,Ellerbeck U

更新日期：2001-01-01 00:00:00

abstract：:Bath salts, fumigations, cleaners and air fresheners, behind these terms substances are hidden, which count as "Legal Highs". These fancy names are used to pretend Legal Highs as harmless compounds, to circumvent legal regulations for marketing as well as to increase the sales. Besides classic illicit drugs of synthet...

journal_title：Chirality

authors： Kadkhodaei K,Kadisch M,Schmid MG

更新日期：2020-01-01 00:00:00

abstract：:The objective of this brief highlight is to point out the central role of the exciton chirality method to gain insights on the structural basis of the recently achieved ligand gating of synthetic ion channels. This unprecedented ligand gating was achieved with an equally unprecedented transmembrane rigid-rod pi-stack ...

journal_title：Chirality

authors： Sakai N,Talukdar P,Matile S

更新日期：2006-02-01 00:00:00

abstract：:Ropivacaine hydrochloride monohydrate (ropivacaine) is a new local anaesthetic agent which is administered exclusively as the (-)-(S)-form. The aim of the study was to determine whether metabolic racemisation of (-)-(S)-ropivacaine occurs. This was tested in man, rat, dog, and sheep after different routes of administr...

journal_title：Chirality

authors： Arvidsson T,Bruce HF,Halldin MM

更新日期：1995-01-01 00:00:00

abstract：:The macrocyclic glycopeptide, ristocetin A, was covalently bonded to a silica gel support and evaluated as a liquid chromatographic (LC) chiral stationary phase (CSP). Over 230 racemates were resolved in either the reversed-phase mode, the normal-phase mode, or the polar-organic mode. The retention behavior and select...

journal_title：Chirality

authors： Ekborg-Ott KH,Liu Y,Armstrong DW

更新日期：1998-01-01 00:00:00

abstract：:Stereoselective aspects of pharmacokinetics and metabolism of a chiral nonsteroidal antiinflammatory drug, flobufen, 4-(2', 4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid, were studied in male guinea pigs after p.o. administration of racemic flobufen (rac-flobufen) at a dose of 10 mg/kg. Blood samples were coll...

journal_title：Chirality

authors： Trejtnar F,Král R,Pávek P,Wsól V

更新日期：2003-10-01 00:00:00

abstract：:Studies on the interactions between L-O- phosphoserine, as one of the simplest fragments of membrane components, and the Cinchona alkaloid cinchonine, in the crystalline state were performed. Cinchoninium L-O-phosposerine salt dihydrate (PhSerCin) crystallizes in a monoclinic crystal system, space group P2(1), with un...

journal_title：Chirality

authors： Wesełucha-Birczyńska A,Oleksyn BJ,Watroba J

更新日期：2010-06-01 00:00:00

abstract：:Methods for the resolution of (+/-)-1-methyl-7-oxabicyclo[2.2.1]heptan-2-one 1, a versatile chiral building block for terpenoids, have been investigated. While no efficient result was obtained with kinetic resolution methods, both enantiomers of 1 were prepared optically pure for the first time via esterification of t...

journal_title：Chirality

authors： Guan YK,Li YL

更新日期：2005-02-01 00:00:00

abstract：:Trigonostemons G and H, two novel dimeric dinorditerpenoids, were isolated from the stem barks of Trigonostemon chinensis. Their planar structures and relative configurations were established by extensive analysis of spectroscopic data. Trigonostemons G and H possess a homodimeric biaryl skeleton obtained from two rea...

journal_title：Chirality

authors： Zhu Q,Tang C,Mándi A,Kurtán T,Ye Y

更新日期：2020-03-01 00:00:00

abstract：:Antimalarial drugs have shown potential in suppressing the role of glycosaminoglycans (GAGs) in the pathology of prion protein conformational disorders (e.g. "Mad Cow" disease) by competing for sites of electrostatic interaction. In this study, circular dichroism (CD) and UV/Visible (UV/Vis) absorption spectroscopy te...

journal_title：Chirality

authors： Stanley FE,Warner AM,McWilliams KM,Stalcup AM

更新日期：2011-01-01 00:00:00

abstract：:This study focused on the chiral characteristics of methamphetamine seizures in Shanghai for inferring the synthetic pathways of drugs. Capillary electrophoresis coupled to time-of-flight mass spectrometry was used for simultaneous chiral separation of amphetamine-type stimulants and ephedrine, including S(+)-amphetam...

journal_title：Chirality

authors： Cui X,Liang C,Gong F,Wang R,Ni C,Wu Y,Chen G,Zhang Y

更新日期：2018-09-01 00:00:00

abstract：:A calculation of the circular dichroism (CD) spectra of carbonmonoxy- and deoxy-myoglobin is carried out in relation to a time-resolved CD experiment. This calculation allows us to assign a dominant role to the proximal histidine in the definition of the electronic normal modes and to interpret the transient CD struct...

journal_title：Chirality

authors： Dartigalongue T,Hache F

更新日期：2006-05-05 00:00:00

abstract：:We report here a sensitive method for the determination of the absolute configurations of primary amines using exciton-coupled circular dichroism (ECCD). The method works on a microgram scale by derivatization of chiral amines with quinoline chromophores. Complexation of the chiral ligands with metal ion fixes the geo...

journal_title：Chirality

authors： Zhang J,Holmes AE,Sharma A,Brooks NR,Rarig RS,Zubieta J,Canary JW

更新日期：2003-02-01 00:00:00

abstract：:Chiral natural flavor compounds exhibit characteristic enantiomeric excesses due to stereoselective, enzymatically catalyzed reactions during biogenesis. Although the enzymatic formation of the strawberry key flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF; Furaneol(R)) is anticipated, the naturally occurr...

journal_title：Chirality

authors： Raab T,Hauck T,Knecht A,Schmitt U,Holzgrabe U,Schwab W

更新日期：2003-08-01 00:00:00

abstract：:A new enantiomerically pure P-chiral phosphine, (S)-cyclohexylmethyl- (1-naphthyl)phosphine (1) was prepared by phosphine-borane methodology and used in a mechanistic study of the Mitsunobu reaction. Enantiomerically enriched (S)-cyclo- hexylmethyl(1-naphtyl)phosphine oxide (8) is obtained if the reaction proceeds thr...

journal_title：Chirality

authors： Watanabe T,Gridnev ID,Imamoto T

更新日期：2000-06-01 00:00:00