Abstract:
:The macrocyclic glycopeptide, ristocetin A, was covalently bonded to a silica gel support and evaluated as a liquid chromatographic (LC) chiral stationary phase (CSP). Over 230 racemates were resolved in either the reversed-phase mode, the normal-phase mode, or the polar-organic mode. The retention behavior and selectivity of this CSP were examined in each mode. Optimization of separations on this column is discussed. The ristocetin A CSP appeared to be complimentary to other glycopeptide CSPs (i.e., vancomycin and teicoplanin). Column stability was excellent. The CSP was not irreversibly altered when going from one mobile phase to another.
journal_name
Chiralityjournal_title
Chiralityauthors
Ekborg-Ott KH,Liu Y,Armstrong DWdoi
10.1002/(SICI)1520-636X(1998)10:5<434::AID-CHIR10>subject
Has Abstractpub_date
1998-01-01 00:00:00pages
434-83issue
5eissn
0899-0042issn
1520-636Xpii
10.1002/(SICI)1520-636X(1998)10:5<434::AID-CHIR10>journal_volume
10pub_type
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