Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography.

abstract：:A three-dimensional molecularly imprinted overoxidized polypyrrole/MnO2 /carbon felt (MIOPPy/MnO2 /CF) composites were fabricated, which results in increased active area of the surface of the molecularly imprinted polymers film and greatly improved electrochemical chiral recognition effect for tryptophan isomers. The ...

journal_title：Chirality

authors： Dong L,Liu X,Xu H,Wu D,Gao S,Zhong L,Kong Y

更新日期：2019-11-01 00:00:00

abstract：:The use of four cyclodextrins (three native and one beta-CD derivative) as NMR chiral solvating agents to resolve the enantiomers of (+/-)-cizolirtine, 1, and its chemical precursor (the carbinol, (+/-)-2), was investigated. The best enantiodiscrimination occurred when beta-cyclodextrin was used. ROESY experiments wer...

journal_title：Chirality

authors： Redondo J,Blázquez MA,Torrens A

更新日期：1999-01-01 00:00:00

abstract：:Homoprolinol analogs, a class of optically active γ-amino alcohols, were examined systematically in the enantioselective addition reactions of diethylzinc to aldehydes. By comparison of the results catalyzed by these γ-amino alcohols with those by the β-amino alcohols based on pyrrolidine architecture reported in the ...

journal_title：Chirality

authors： Liu CL,Wei CY,Wang SW,Peng YG

更新日期：2011-11-01 00:00:00

abstract：:Three aldohexoses, glucose, galactose, and mannose, and three aldopentoses, arabinose, xylose, and ribose, were derivatized with L-tryptophanamide (L-TrpNH2 ) under alkaline conditions. Using a basic mobile phase (pH 9.2), the three aldohexoses or the three aldopentoses were simultaneously enantioseparated, respective...

journal_title：Chirality

authors： Shou M,Terashima H,Aizawa S,Taga A,Yamamoto A,Kodama S

更新日期：2015-07-01 00:00:00

abstract：:In order to get further insight into the mechanism by which bovine serum albumin (BSA) discriminates between enantiomers of organic acids, some radioisotopically labeled, nonaromatic carboxylic acids were studied under varying mobile phase conditions. It was found for a series of N-alkanoyl-DL-[3H]leucines that the D-...

journal_title：Chirality

authors： Allenmark S

更新日期：1993-01-01 00:00:00

abstract：:The hemicryptophane racemate (±)-1 was optically resolved by semipreparative HPLC on Chiralpak IC column. The absolute configuration of each isolated enantiomer was established from the analysis of their electronic circular dichroism spectra. Enantiodifferentiation of the chiral cationic cage (±)-1 was evidenced in so...

journal_title：Chirality

authors： Payet E,Dimitrov-Raytchev P,Chatelet B,Guy L,Grass S,Lacour J,Dutasta JP,Martinez A

更新日期：2012-12-01 00:00:00

abstract：:The effects of temperature on the chiral recognition of cyclic β-amino acid enantiomers on zwitterionic [Chiralpak ZWIX(+) and ZWIX(-)] chiral stationary phases were investigated. Experiments were performed at different mobile phase compositions and under 10°C column temperature increments in the temperature range 10-...

journal_title：Chirality

authors： Ilisz I,Pataj Z,Gecse Z,Szakonyi Z,Fülöp F,Lindner W,Péter A

更新日期：2014-08-01 00:00:00

abstract：:Efficient synthesis of several new atropisomeric amino alcohols having 1-phenyl-1H-pyrrole skeleton are reported. Steric arrangements of the products were confirmed by a single-crystal X-ray measurement. The consequences of the size of the N-substituents on enantioinduction were examined by employing the enantioselect...

journal_title：Chirality

authors： Faigl F,Deák S,Erdélyi Z,Holczbauer T,Czugler M,Nyerges M,Mátravölgyi B

更新日期：2015-03-01 00:00:00

abstract：:Integrating spheres are widely used with UV-Vis and occasionally with infrared spectrophotometers to measure different types of samples, either in transmission mode (scattered transmission accessories) or in total/diffuse reflectance mode. We built a prototype sphere of the demountable type, which fits easily the samp...

journal_title：Chirality

authors： Castiglioni E,Albertini P

更新日期：2000-05-01 00:00:00

abstract：:Weinreb amide 3 was synthesized using isobutyl chloroformate, carbonyldiimidazole, or ethylcarbodiimide as the coupling agent in the reaction of Boc-phenylalanine with O,N-dimethylhydroxylamine hydrochloride. An optically active oil was isolated along with an optically inactive solid irrespective of the type of coupli...

journal_title：Chirality

authors： Zheng X,Donkor IO,Miller DD,Ross CR 2nd

更新日期：2000-01-01 00:00:00

abstract：:SCH 56592 is a novel triazole antifungal agent that is active both orally and intravenously in animal models of infection. This compound is in Phase II-III clinical trials for the treatment of systemic fungal infections. SCH 56592 is a single enantiomer with four stereogenic centers; therefore, it was necessary to eva...

journal_title：Chirality

authors： Kim H,Lin CC,Laughlin M,Lovey R,Saksena A,Heimark L,Nomeir AA

更新日期：2000-07-01 00:00:00

abstract：:The enantioselective hydrogenation of C==N-C group containing compounds over modified metal catalysts is as yet an uninvestigated research area. This work contains results obtained on the hydrogenation of 1-pyrroline-2-carboxylate esters and sodium salt over cinchona alkaloid-modified alumina-supported Pd catalyst. Th...

journal_title：Chirality

authors： Szöllösi G,Kun I,Bartók M

更新日期：2001-01-01 00:00:00

abstract：:Subcellular fractions of three human brain specimens were found to contain esterase activities which hydrolyzed racemic oxazepam 3-acetate (rac-OXA). All three human brain preparations were highly selective toward the S-enantiomer of rac-OXA. ...

journal_title：Chirality

authors： Yang SK,Huang A,Huang JD

更新日期：1993-01-01 00:00:00

abstract：:Caffeic acid-derived polyethers are a class of natural products isolated from the root extracts of comfrey and bugloss, which are endowed with intriguing pharmacological properties as anticancer agents. The synthesis of new polyether derivatives is achieved through ring-opening polymerization of chiral 2,3-disubstitut...

journal_title：Chirality

authors： Tedesco D,Fabini E,Barbakadze V,Merlani M,Zanasi R,Chankvetadze B,Bertucci C

更新日期：2015-12-01 00:00:00

abstract：:Six enantiomeric pairs of TADDOL-s gathered in two series with either methyl (series A) or phenyl (series B) substituent in 2-position of the dioxolane ring were studied by vibrational circular dichroism (VCD). Experimental IR and VCD spectra associated with density functional theory (DFT) calculations showed that the...

journal_title：Chirality

authors： Uncuta C,Bartha E,Gherase D,Teodorescu F,Draghici C,Cavagnat D,Daugey N,Liotard D,Buffeteau T

更新日期：2010-01-01 00:00:00

abstract：:The chiral separation by counter-current chromatography has made great progress in the past three decades. It has become increasingly popular in the field of chiral separation, and many applications have been introduced during the last years. This review mainly focuses on the current topics, applications, and trends i...

journal_title：Chirality

authors： Duan WD,Huang XY,Di DL

更新日期：2020-10-01 00:00:00

abstract：:We studied the interaction of poly-l-lysine (PLL) and poly-l-arginine (PLAG) with sodium dodecyl sulfate (SDS) surfactant and the interaction of poly-l-glutamic acid (PLGA) and poly-l-aspartic acid (PLAA) with tetradecyltrimethylammonium bromide (TTAB) surfactant using vibrational circular dichroism (VCD) spectroscopy...

journal_title：Chirality

authors： Novotná P,Urbanová M

更新日期：2015-12-01 00:00:00

abstract：:Ifosfamide (IF), a potent chemotherapeutic agent for solid tumors, is known to cause high rates of nephrotoxicity in children with cancer, which is most likely due to the renal production of the metabolite chloroacetaldehyde. Using plasma samples obtained from pediatric oncology patients, we developed a simple nonderi...

journal_title：Chirality

authors： Aleksa K,Nava-Ocampo A,Koren G

更新日期：2009-07-01 00:00:00

abstract：:Diamino carboxylic acids have recently come to the attention of scientists working in the field of early life and its development. These are the monomers of a hypothetic early form of genetic material, the so-called Peptide Nucleic Acid (PNA) (Nielson et al., Proc Natl Acad Sci USA 2000;97:3868-3871). Since all biopol...

journal_title：Chirality

authors： Bredehöft JH,Breme K,Meierhenrich UJ,Hoffmann SV,Thiemann WH

更新日期：2007-07-01 00:00:00

abstract：:Despite the fact that several studies have reported the concentrations of various free amino acids in tobacco, their enantiomeric composition is unknown. Both the absolute and enantiomeric compositions of proline, alanine, asparagine, aspartic acid, valine, methionine, leucine,and phenylalanine were determined for thr...

journal_title：Chirality

authors： Kullman JP,Chen X,Armstrong DW

更新日期：1999-01-01 00:00:00

abstract：:This paper reports the enantioseparation of β-hydroxy-1,2,3-triazole derivatives, which present a broad range of biological properties, by supercritical fluid chromatography (SFC) and high-performance liquid chromatography techniques (HPLC). Polysaccharide-based chiral columns (cellulose and amylose) were used to eval...

journal_title：Chirality

authors： Alvarenga N,Porto ALM,Barreiro JC

更新日期：2018-07-01 00:00:00

abstract：:Enzymatic hydrolysis with beta-glucuronidase/sulfatase was used for the enantioselective determination of N-hydroxymexiletine glucuronide in plasma for pharmacokinetic studies. N-Hydroxymexiletine glucuronide was determined as the quantity of mexiletine released by hydrolysis (difference between the enantiomeric conce...

journal_title：Chirality

authors： Lanchote VL,Santos VJ,Cesarino EJ,Dreossi SA,Mere Júnior Y,Santos SR

更新日期：1999-01-01 00:00:00

abstract：:We report the preparative separation of rac-zopiclone using malic acid as the resolving agent. Furthermore, two different methods for the analytical determination of zopiclone enantiomers by HPLC on chiral stationary phases are described. The benzodiazepine receptor binding of the isolated enantiomers was investigated...

journal_title：Chirality

authors： Blaschke G,Hempel G,Müller WE

更新日期：1993-01-01 00:00:00

abstract：:After alkylation of a fraction of the total alpha-adrenoreceptors by phenoxybenzamine in rat vas deferens, the dissociation constants of (-)- and (+)-epinephrine in functional studies were 7 X 10(-7) M and 2 X 10(-5) M, respectively. In the adrenoreceptor-containing tissue fraction, when 3H-labeled WB4101 was used as ...

journal_title：Chirality

authors： Rice PJ,Miller DD,Sokoloski TD,Patil PN

更新日期：1989-01-01 00:00:00

abstract：:Chiral molecules can either be handed (i.e., "shoes") or nonhanded ("potatoes"). The only chiral ligand partition for tetrahedral metal complexes (or for a tetrahedral carbon atom such as that found in amino acids and other chiral biological molecules) is the fully unsymmetrical degree 6 partition (1(4)), which leads ...

journal_title：Chirality

authors： King RB

更新日期：2001-08-01 00:00:00

abstract：:A new colorimetric chiral sensor material consisting of three different functional sites such as chromophore (2,4-dinitrophenylazophenol dye), binding site (crown ether), and chiral barrier (3,3'-diphenyl-1,1'-binaphthyl group) was prepared and applied to the recognition of the two enantiomers of primary amino alcohol...

journal_title：Chirality

authors： Cho EN,Li Y,Kim HJ,Hyun MH

更新日期：2011-04-01 00:00:00

abstract：:Here, we report the general strategies by which NMR spectroscopy can be used to determine the enantiopurity and absolute configuration of chalcogen containing secondary alcohols, including the evaluation of the use of chiral solvating and chiral derivatizing agents. The BINOL/DMAP ternary complex demonstrated a simple...

journal_title：Chirality

authors： Marques NBG,Jacob RG,Perin G,Lenardão EJ,Alves D,Silva MS

更新日期：2019-01-01 00:00:00

abstract：:A simple one-dimensional (13)C NMR method is presented to discriminate between stereoisomers of organic compounds with more than one chiral center. By means of this method it is possible to discriminate between all eight stereoisomers of α-tocopherol. To achieve this the chiral solvating agent (S)-(+)-1-(9-anthryl)-2,...

journal_title：Chirality

authors： Lankhorst PP,Netscher T,Duchateau AL

更新日期：2015-11-01 00:00:00

abstract：:(R,R)-formoterol was synthesized in seven steps with 4-hydroxyl-3-nitro-acetophenone as the starting material. The key intermediate, the chiral secondary alcohol 4, was prepared via Rh-catalyzed asymmetric transfer hydrogenation with (S,S)-PEGBsDPEN as the ligand and sodium formate as the hydrogen donor under mild con...

journal_title：Chirality

authors： Huang L,Liu J,Shan W,Liu B,Shi A,Li X

更新日期：2010-02-01 00:00:00

abstract：:E-6087 is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2. Because E-6087 has a chiral center, this compound is a racemic mixture of two stereoisomers, (+)-(R)-E-6087 (E-6231) and (-)-(S)-E-6087 (E-6232). A normal-phase liquid-chromatographic method for the enantioselective determi...

journal_title：Chirality

authors： Salgado L,Encina G,Farran R,Puig S,Martínez L

更新日期：2004-05-15 00:00:00