Abstract:
:Here, we report the general strategies by which NMR spectroscopy can be used to determine the enantiopurity and absolute configuration of chalcogen containing secondary alcohols, including the evaluation of the use of chiral solvating and chiral derivatizing agents. The BINOL/DMAP ternary complex demonstrated a simple and fast protocol for determining enantiopurity. The drug Naproxen afforded a stable, nonhygroscopic, and readily available chiral derivatizing agent (CDA) for NMR chiral discrimination of chalcogen containing secondary alcohols. The chiral recognition by CDA and chiral solvating agent (CSA) was assessed using 1 H, 77 Se-{1H}, and 125 Te-{1H} NMR spectroscopy. A simple model for the assignment of the absolute configuration from NMR data is presented.
journal_name
Chiralityjournal_title
Chiralityauthors
Marques NBG,Jacob RG,Perin G,Lenardão EJ,Alves D,Silva MSdoi
10.1002/chir.23030subject
Has Abstractpub_date
2019-01-01 00:00:00pages
41-51issue
1eissn
0899-0042issn
1520-636Xjournal_volume
31pub_type
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