Chiral separations on polysaccharide stationary phases using polar organic mobile phases.

Abstract:

:About 30% of a chemically diverse set of compounds were found to separate on four polysaccharide chiral stationary phases using polar organic mobile phases. No structural features appeared to correlate to successful separations. Titrations between normal and polar organic mobile phases suggested that separation mechanisms do not differ between these mobile phases. Attempts made to control retention met with varying degrees of success. Addition of hexane to alcohols had minor effects on retention although this was occasionally beneficial. Addition of water to alcohols increased retention. Addition of water to acetonitrile decreased retention. Addition of alcohol to acetonitrile also proved beneficial to the separation of some compounds. Loading studies performed to mimic preparative separations indicated that the benefits of polar organic mobile phases are largely due to increased solubility.

journal_name

Chirality

journal_title

Chirality

authors

Lynam KG,Stringham RW

doi

10.1002/chir.20212

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

1-9

issue

1

eissn

0899-0042

issn

1520-636X

journal_volume

18

pub_type

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