Abstract:
:About 30% of a chemically diverse set of compounds were found to separate on four polysaccharide chiral stationary phases using polar organic mobile phases. No structural features appeared to correlate to successful separations. Titrations between normal and polar organic mobile phases suggested that separation mechanisms do not differ between these mobile phases. Attempts made to control retention met with varying degrees of success. Addition of hexane to alcohols had minor effects on retention although this was occasionally beneficial. Addition of water to alcohols increased retention. Addition of water to acetonitrile decreased retention. Addition of alcohol to acetonitrile also proved beneficial to the separation of some compounds. Loading studies performed to mimic preparative separations indicated that the benefits of polar organic mobile phases are largely due to increased solubility.
journal_name
Chiralityjournal_title
Chiralityauthors
Lynam KG,Stringham RWdoi
10.1002/chir.20212subject
Has Abstractpub_date
2006-01-01 00:00:00pages
1-9issue
1eissn
0899-0042issn
1520-636Xjournal_volume
18pub_type
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