Ion channels as pharmacologic receptors: the chirality of drug interactions.

Abstract:

:Ion channels are pharmacologic receptors and as such exhibit stereoselective interactions with drugs. Ion channels are conformationally mobile transmembrane proteins existing in a number of open and closed states. Drug interactions with these different states may differ quantitatively and qualitatively. Stereoselectivity may not be a constant factor and may change according to channel state as determined by stimulus mode or experimental conditions. Selected examples are cited for Na+ and Ca2+ channels.

journal_name

Chirality

journal_title

Chirality

authors

Triggle DJ

doi

10.1002/(SICI)1520-636X(1996)8:1<35::AID-CHIR8>3.0

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

35-8

issue

1

eissn

0899-0042

issn

1520-636X

pii

10.1002/(SICI)1520-636X(1996)8:1<35::AID-CHIR8>3.0

journal_volume

8

pub_type

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