Abstract:
:Ion channels are pharmacologic receptors and as such exhibit stereoselective interactions with drugs. Ion channels are conformationally mobile transmembrane proteins existing in a number of open and closed states. Drug interactions with these different states may differ quantitatively and qualitatively. Stereoselectivity may not be a constant factor and may change according to channel state as determined by stimulus mode or experimental conditions. Selected examples are cited for Na+ and Ca2+ channels.
journal_name
Chiralityjournal_title
Chiralityauthors
Triggle DJdoi
10.1002/(SICI)1520-636X(1996)8:1<35::AID-CHIR8>3.0subject
Has Abstractpub_date
1996-01-01 00:00:00pages
35-8issue
1eissn
0899-0042issn
1520-636Xpii
10.1002/(SICI)1520-636X(1996)8:1<35::AID-CHIR8>3.0journal_volume
8pub_type
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