Abstract:
:Chiral sulfoxides/N-oxides (R)-1 and (R,R)-2 are effective chiral promoters in the enantioselective allylation of α-keto ester N-benzoylhydrazone derivatives 3a-g to generate the corresponding N-benzoylhydrazine derivatives 4a-g, with enantiomeric excesses as high as 98%. Representative hydrazine derivatives 4a-b were subsequently treated with SmI2, and the resulting amino esters 5a-b with LiOH to obtain quaternary α-substituted α-allyl α-amino acids 6a-b, whose absolute configuration was assigned as (S), with fundament on chemical correlation and electronic circular dichroism (ECD) data.
journal_name
Chiralityjournal_title
Chiralityauthors
Reyes-Rangel G,Bandala Y,García-Flores F,Juaristi Edoi
10.1002/chir.22159subject
Has Abstractpub_date
2013-09-01 00:00:00pages
529-40issue
9eissn
0899-0042issn
1520-636Xjournal_volume
25pub_type
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