Enantioselective separation of (±)-β-hydroxy-1,2,3-triazoles by supercritical fluid chromatography and high-performance liquid chromatography.

Abstract:

:This paper reports the enantioseparation of β-hydroxy-1,2,3-triazole derivatives, which present a broad range of biological properties, by supercritical fluid chromatography (SFC) and high-performance liquid chromatography techniques (HPLC). Polysaccharide-based chiral columns (cellulose and amylose) were used to evaluate the separation in SFC and HPLC. Time of analyses, consumption of solvent, and parameter optimization were reduced using SFC technique. The columns based on cellulose chiral stationary phase using 2-propanol and ethanol as modifiers showed the best results for the enantioresolution of the (±)-β-hydroxy-1,2,3-triazoles by SFC analyses. These techniques were applied to evaluate the selectivity of biocatalytic reduction of β-keto-1,2,3-triazoles by marine-derived fungus Penicillium citrinum CBMAI 1186 to obtain the (±)-β-hydroxy-1,2,3-triazoles.

journal_name

Chirality

journal_title

Chirality

authors

Alvarenga N,Porto ALM,Barreiro JC

doi

10.1002/chir.22851

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

890-899

issue

7

eissn

0899-0042

issn

1520-636X

journal_volume

30

pub_type

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