Abstract:
:This paper reports the enantioseparation of β-hydroxy-1,2,3-triazole derivatives, which present a broad range of biological properties, by supercritical fluid chromatography (SFC) and high-performance liquid chromatography techniques (HPLC). Polysaccharide-based chiral columns (cellulose and amylose) were used to evaluate the separation in SFC and HPLC. Time of analyses, consumption of solvent, and parameter optimization were reduced using SFC technique. The columns based on cellulose chiral stationary phase using 2-propanol and ethanol as modifiers showed the best results for the enantioresolution of the (±)-β-hydroxy-1,2,3-triazoles by SFC analyses. These techniques were applied to evaluate the selectivity of biocatalytic reduction of β-keto-1,2,3-triazoles by marine-derived fungus Penicillium citrinum CBMAI 1186 to obtain the (±)-β-hydroxy-1,2,3-triazoles.
journal_name
Chiralityjournal_title
Chiralityauthors
Alvarenga N,Porto ALM,Barreiro JCdoi
10.1002/chir.22851subject
Has Abstractpub_date
2018-07-01 00:00:00pages
890-899issue
7eissn
0899-0042issn
1520-636Xjournal_volume
30pub_type
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