Abstract:
:The prochiral anthelmintic drug albendazole was administered orally to sheep and rats. Blood samples were taken at standardized intervals during the time course of the plasma kinetics: 18 h in rats and 48 h in sheep. The enantiomeric ratio of the sulfoxide metabolite was determined by means of HPLC on a chiral stationary phase, the chiral selector of which was a N-3,5-dinitrobenzoyl derivative of (S)-tyrosine. Two enantiomers were detected in both animal species but their ratios were inverted in rat vs. sheep. The evolution of the ratio is turned from a racemate at 15 min to 60(-):40(+) at 12 h in rats, while it moved from 23(-):77(+) at 3 h to 4(-):96(+) at 36 h after administration in sheep.
journal_name
Chiralityjournal_title
Chiralityauthors
Delatour P,Benoit E,Caude M,Tambute Adoi
10.1002/chir.530020306subject
Has Abstractpub_date
1990-01-01 00:00:00pages
156-60issue
3eissn
0899-0042issn
1520-636Xjournal_volume
2pub_type
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