Abstract:
:A simple one-dimensional (13)C NMR method is presented to discriminate between stereoisomers of organic compounds with more than one chiral center. By means of this method it is possible to discriminate between all eight stereoisomers of α-tocopherol. To achieve this the chiral solvating agent (S)-(+)-1-(9-anthryl)-2,2,2-trifluoroethanol and the compound of interest were dissolved in high concentrations in chloroform-d, and the nuclear magnetic resonance (NMR) spectrum was recorded at a low temperature. The individual stereoisomers of α-tocopherol were assigned by spikes of the reference compounds. The method was also applied to six other representative examples.
journal_name
Chiralityjournal_title
Chiralityauthors
Lankhorst PP,Netscher T,Duchateau ALdoi
10.1002/chir.22535subject
Has Abstractpub_date
2015-11-01 00:00:00pages
850-5issue
11eissn
0899-0042issn
1520-636Xjournal_volume
27pub_type
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