Chiral discrimination by albumin: a mechanistic study of liquid chromatographic optical resolution of nonaromatic carboxylic acids.

abstract：:Subcellular fractions of three human brain specimens were found to contain esterase activities which hydrolyzed racemic oxazepam 3-acetate (rac-OXA). All three human brain preparations were highly selective toward the S-enantiomer of rac-OXA. ...

journal_title：Chirality

authors： Yang SK,Huang A,Huang JD

更新日期：1993-01-01 00:00:00

abstract：:About 30% of a chemically diverse set of compounds were found to separate on four polysaccharide chiral stationary phases using polar organic mobile phases. No structural features appeared to correlate to successful separations. Titrations between normal and polar organic mobile phases suggested that separation mechan...

journal_title：Chirality

authors： Lynam KG,Stringham RW

更新日期：2006-01-01 00:00:00

abstract：:The elusive epimerization process in the chiral butenolide moiety of Annonaceous acetogenins was examined under several sets of conditions commonly used for elimination leading to the alpha, beta-unsaturated lactone and the results provide practical guidance in choosing elimination conditions. ...

journal_title：Chirality

authors： Yu Q,Wu Y,Wu YL,Xia LJ,Tang MH

更新日期：2000-03-01 00:00:00

abstract：:The simultaneous disposition of fenoprofen enantiomers in synovial fluid and plasma was studied in 11 patients with arthritis and chronic knee effusions treated with a single oral dose of 600 mg rac-fenoprofen. A plasma sample and a synovial fluid sample were collected simultaneously from each patient up to 16 h after...

journal_title：Chirality

authors： De Miranda Silva C,Marques MP,Barissa GR,Donadi EA,Da Silva LM,Lanchote VL

更新日期：2007-05-05 00:00:00

abstract：:This work reports confirmation of the experimental assignment of the absolute-handedness chirality of single-walled carbon nanotubes (SWNTs). This was achieved by applying the scanning tunneling microscopy (STM) imaging technique to a supramolecular composite consisting of a metalized porphyrin derivative (nickel-5,15...

journal_title：Chirality

authors： Abd El-Mageed AIA,Ogawa T

更新日期：2020-03-01 00:00:00

abstract：:A new colorimetric chiral sensor material consisting of three different functional sites such as chromophore (2,4-dinitrophenylazophenol dye), binding site (crown ether), and chiral barrier (3,3'-diphenyl-1,1'-binaphthyl group) was prepared and applied to the recognition of the two enantiomers of primary amino alcohol...

journal_title：Chirality

authors： Cho EN,Li Y,Kim HJ,Hyun MH

更新日期：2011-04-01 00:00:00

abstract：:The application of helical poly[(S)-3-vinyl-2,2'-dihydroxy-1, 1'-binaphthyl] (L*) in the asymmetric borane reduction of prochiral ketones was studied. The results showed that L* had excellent catalytic activity as well as enantioselectivity, giving up to 96% yield and up to 99% enantiomeric excess (ee) of the correspo...

journal_title：Chirality

authors： Qin G,Chen Y,Yang L,Yang N,Yang Z

更新日期：2015-07-01 00:00:00

abstract：:Mirror symmetry breaking is ubiquitous in our visible universe taking place in elementary particles, atoms, and molecules. Molecular chirality is not biogenic in itself, although its detection is often considered a biosignature, a conjecture inferred from the fact that we do not know life devoid of homochirality. The ...

journal_title：Chirality

authors： Cintas P,Viedma C

更新日期：2012-11-01 00:00:00

abstract：:This work presents results of methyl 7-oxoabiet-13(14)-en-18-oate (3) self-oxidation with air-oxygen in the presence of various bases such as triethylamine or sodium t-butoxide. While under aerobic conditions, the use of sodium t-butoxide as a base results in the formation of four isomeric alcohols, an addition of tri...

journal_title：Chirality

authors： Masnyk M,Kuśmirek D,Trzybiński D,Frelek J

更新日期：2020-04-01 00:00:00

abstract：:This paper reports the enantioseparation of β-hydroxy-1,2,3-triazole derivatives, which present a broad range of biological properties, by supercritical fluid chromatography (SFC) and high-performance liquid chromatography techniques (HPLC). Polysaccharide-based chiral columns (cellulose and amylose) were used to eval...

journal_title：Chirality

authors： Alvarenga N,Porto ALM,Barreiro JC

更新日期：2018-07-01 00:00:00

abstract：:A simple one-dimensional (13)C NMR method is presented to discriminate between stereoisomers of organic compounds with more than one chiral center. By means of this method it is possible to discriminate between all eight stereoisomers of α-tocopherol. To achieve this the chiral solvating agent (S)-(+)-1-(9-anthryl)-2,...

journal_title：Chirality

authors： Lankhorst PP,Netscher T,Duchateau AL

更新日期：2015-11-01 00:00:00

abstract：:Numbers of resolving factors were investigated to improve resolution of venlafaxine 1. An effective resolving agent, O,O'-di-p-toluoyl-(R, R)-tartaric acid 2, was screened using similar method of 'Dutch resolution' from tartaric acid derivatives. The resolution efficiency was up to 88.4%, when the ratio of rac-1 and 2...

journal_title：Chirality

authors： Liu ZJ,Liu H,Chen XW,Lin M,Hu Y,Tuo X,Yuan ZY,Sun XX

更新日期：2018-03-01 00:00:00

abstract：:The initial step in the metabolism of dolasetron or MDL 73,147EF [(2 alpha, 6 alpha, 8 alpha, 9a beta)-octahydro-3-oxo-2,6-methano-2H- quinolizin-8-yl 1H-indol-3-carboxylate, monomethanesulfonate] is the reduction of the prochiral carbonyl group to give a chiral secondary alcohol "reduced dolasetron." An HPLC method, ...

journal_title：Chirality

authors： Dow J,Berg C

更新日期：1995-01-01 00:00:00

abstract：:Little is known about the stereochemistry of sulfation of chiral phenolic drugs. In this study we examined several in vitro approaches to this question, using (+)-, (-)-, or (+/-)-terbutaline as the substrate and the rat liver cytosol as the phenolsulfotransferase enzyme source. The cosubstrate PAPS was either generat...

journal_title：Chirality

authors： Walle UK,Walle T

更新日期：1989-01-01 00:00:00

abstract：:Ropivacaine hydrochloride monohydrate (ropivacaine) is a new local anaesthetic agent which is administered exclusively as the (-)-(S)-form. The aim of the study was to determine whether metabolic racemisation of (-)-(S)-ropivacaine occurs. This was tested in man, rat, dog, and sheep after different routes of administr...

journal_title：Chirality

authors： Arvidsson T,Bruce HF,Halldin MM

更新日期：1995-01-01 00:00:00

abstract：:We have developed an improved circular dichroism (CD) and linear dichroism (LD) simultaneous measurement system for the vacuum ultraviolet (VUV) region by polarization modulation techniques using a four-period Onuki-type crossed undulator as a polarized light source. The system has been constructed at the VUV beamline...

journal_title：Chirality

authors： Tanaka M,Yagi-Watanabe K,Yamada T,Kaneko F,Nakagawa K

更新日期：2006-02-01 00:00:00

abstract：:Three N,N-dimethylcarbamyl derivatives of oxazepam (1-(N,N-dimethylcarbamyl)oxazepam, 3-O-(N,N-dimethylcarbamyl)oxazepam, and 1,3-O-bis(N,N-dimethylcarbamyl) oxazepam) and a 3-O-acyl-1-(N,N-dimethylcarbamyl)-oxazepam were synthesized from either oxazepam or demoxepam. Enantiomeric pairs of these derivatives and of cam...

journal_title：Chirality

authors： Yang SK,Lu XL

更新日期：1991-01-01 00:00:00

abstract：:Novel chiral diisopropyl spiro bis(isoxazoline) ligands, anti-i-Pr-SPRIX and syn-i-Pr-SPRIX, were designed and synthesized. Their catalytic utility, X-ray crystallographic analyses, and complexation studies demonstrated the structural features of tetraisopropyl spiro bis(isoxazoline) ligand, i-Pr-SPRIX, which is a pro...

journal_title：Chirality

authors： Takenaka K,Lin X,Takizawa S,Sasai H

更新日期：2015-08-01 00:00:00

abstract：:Cyclic triamides bearing amidino groups at the meta position of the phenyl rings were synthesized, and their conformational properties in the crystal and in solution were examined. Compound exists as a capsule-type dimer of the enantiomers with a bowl-shaped syn conformation in the crystal state. Compound exists mainl...

journal_title：Chirality

authors： Nishiyama S,Urushibara K,Masu H,Azumaya I,Kagechika H,Tanatani A

更新日期：2015-08-01 00:00:00

abstract：:Weinreb amide 3 was synthesized using isobutyl chloroformate, carbonyldiimidazole, or ethylcarbodiimide as the coupling agent in the reaction of Boc-phenylalanine with O,N-dimethylhydroxylamine hydrochloride. An optically active oil was isolated along with an optically inactive solid irrespective of the type of coupli...

journal_title：Chirality

authors： Zheng X,Donkor IO,Miller DD,Ross CR 2nd

更新日期：2000-01-01 00:00:00

abstract：:Chiral fungicide prothioconazole has a wide range of antifungal spectrum; however, little research has been conducted to evaluate prothioconazole on an enantiomeric level. Five target pathogens and three common aquatic organisms were tested for the enantioselective bioactivity and toxicity of prothioconazole in this w...

journal_title：Chirality

authors： Zhai W,Zhang L,Cui J,Wei Y,Wang P,Liu D,Zhou Z

更新日期：2019-06-01 00:00:00

abstract：:Enantioselective catalytic epoxidation of olefins is an important problem from both practical and mechanistic points of view. The origins of chiral induction by asymmetric porphyrin and salen complexes were investigated by FT-NMR T1 relaxation techniques. A new chiral vaulted porphyrin (1) that carries (S)-binaphthyl-...

journal_title：Chirality

authors： Groves JT,Crowley SJ,Shalyaev KV

更新日期：1998-01-01 00:00:00

abstract：:Rabeprazole is an effective proton pump inhibitor to treat acid-related diseases. To achieve the simultaneous determination of rabeprazole enantiomers in human plasma, a chiral LC-MS/MS method was developed and validated. Acetonitrile including 0.1% ammonium were used as protein precipitating agent. Analytes were sepa...

journal_title：Chirality

authors： Sun LN,Shen YW,Ying YW,Li D,Li TF,Zhang XH,Zhao P,Ding L,Wang YQ

更新日期：2018-12-01 00:00:00

abstract：:The chiral separation by counter-current chromatography has made great progress in the past three decades. It has become increasingly popular in the field of chiral separation, and many applications have been introduced during the last years. This review mainly focuses on the current topics, applications, and trends i...

journal_title：Chirality

authors： Duan WD,Huang XY,Di DL

更新日期：2020-10-01 00:00:00

abstract：:Enantiomers of chiral aliphatic hydrocarbons are generally difficult to separate because they lack functional groups to be derivatized in order to generate diastereomers. The systematic and quantitative separation of a series of branched hydrocarbon enantiomers using a chiral cyclodextrin stationary phase and a cryost...

journal_title：Chirality

authors： Meierhenrich UJ,Nguyen MJ,Barbier B,Brack A,Thiemann WH

更新日期：2003-01-01 00:00:00

abstract：:8-Prenylnaringenin (8PN) is a naturally occurring bioactive chiral prenylflavonoid found most commonly in the female flowers of hops (Humulus lupulus L.). A stereospecific method of analysis for 8PN in biological fluids is necessary to study the pharmacokinetic disposition of each enantiomer. A novel and simple liquid...

journal_title：Chirality

authors： Martinez SE,Lakowski TM,Davies NM

更新日期：2014-08-01 00:00:00

abstract：:Cyclodextrins that are indiscriminately carboxymethylated at the 2-, 3-, and 6-positions are used as chiral NMR solvating agents for cationic substrates with phenyl, naphthyl, pyridyl, indoline, and indole rings. Enantiodifferentiation with the alpha-, beta-, and gamma-cyclodextrin derivatives is compared. The carboxy...

journal_title：Chirality

authors： Provencher KA,Weber MA,Randall LA,Cunningham PR,Dignam CF,Wenzel TJ

更新日期：2010-03-01 00:00:00

abstract：:Gold particles covered with 1,1'-binaphthyl-2,2'-dithiol (BINAS) were prepared. Using size exclusion chromatography, it was possible for the first time to separate the sample into fractions with different sizes and colors. Transmission electron microscopy shows that the particles are very small, in the order of 1 nm o...

journal_title：Chirality

authors： Gautier C,Taras R,Gladiali S,Bürgi T

更新日期：2008-03-01 00:00:00

abstract：:The direct Michael addition reaction of cyclohexanone/aliphatic aldehydes with nitroolefins, catalyzed by a novel chiral pyrrolidine-thiourea catalyst 1a, is described. The desired 1,4-adducts were obtained in moderate yields with enantioselectivities up to 99% ee and dr up to 99:1 of the syn product. ...

journal_title：Chirality

authors： Shen Z,Zhang Y,Jiao C,Li B,Ding J,Zhang Y

更新日期：2007-05-05 00:00:00

abstract：:A sensitive and stereospecific liquid chromatography-tandem mass spectrometry method for the quantitative determination of TWo8 enantiomers ((2RS)-1-(7-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)-propan-2-ol) was developed and validated in rat serum and some tissues. Racemic TWo8 is a new chemical ent...

journal_title：Chirality

authors： Walczak M,Szymura-Oleksia J,Groszek G

更新日期：2012-08-01 00:00:00