Abstract:
:Weinreb amide 3 was synthesized using isobutyl chloroformate, carbonyldiimidazole, or ethylcarbodiimide as the coupling agent in the reaction of Boc-phenylalanine with O,N-dimethylhydroxylamine hydrochloride. An optically active oil was isolated along with an optically inactive solid irrespective of the type of coupling agent used. Single crystal X-ray analysis of the solid revealed that it is a racemate. The molecular packing of the crystals reflect the stability of the racemate as opposed to an enantiomerically pure solid.
journal_name
Chiralityjournal_title
Chiralityauthors
Zheng X,Donkor IO,Miller DD,Ross CR 2nddoi
10.1002/(SICI)1520-636X(2000)12:1<2::AID-CHIR2>3.0subject
Has Abstractpub_date
2000-01-01 00:00:00pages
2-6issue
1eissn
0899-0042issn
1520-636Xpii
10.1002/(SICI)1520-636X(2000)12:1<2::AID-CHIR2>3.0journal_volume
12pub_type
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