Abstract:
:(R,R)-formoterol was synthesized in seven steps with 4-hydroxyl-3-nitro-acetophenone as the starting material. The key intermediate, the chiral secondary alcohol 4, was prepared via Rh-catalyzed asymmetric transfer hydrogenation with (S,S)-PEGBsDPEN as the ligand and sodium formate as the hydrogen donor under mild conditions. With a mixture of PEG 2000 and water as the reaction media, the catalyst system could be recycled four times.
journal_name
Chiralityjournal_title
Chiralityauthors
Huang L,Liu J,Shan W,Liu B,Shi A,Li Xdoi
10.1002/chir.20728subject
Has Abstractpub_date
2010-02-01 00:00:00pages
206-11issue
2eissn
0899-0042issn
1520-636Xjournal_volume
22pub_type
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