The asymmetric synthesis of (R,R)-formoterol via transfer hydrogenation with polyethylene glycol bound Rh catalyst in PEG2000 and water.

Abstract:

:(R,R)-formoterol was synthesized in seven steps with 4-hydroxyl-3-nitro-acetophenone as the starting material. The key intermediate, the chiral secondary alcohol 4, was prepared via Rh-catalyzed asymmetric transfer hydrogenation with (S,S)-PEGBsDPEN as the ligand and sodium formate as the hydrogen donor under mild conditions. With a mixture of PEG 2000 and water as the reaction media, the catalyst system could be recycled four times.

journal_name

Chirality

journal_title

Chirality

authors

Huang L,Liu J,Shan W,Liu B,Shi A,Li X

doi

10.1002/chir.20728

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

206-11

issue

2

eissn

0899-0042

issn

1520-636X

journal_volume

22

pub_type

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