New atropisomeric amino alcohol ligands for enantioselective addition of diethylzinc to aldehydes.

abstract：:Chiroptical materials have received much attention in diverse fields for applications such as displays, sensors, smart memory devices, and catalysis. Here, we develop a simple fabrication method for polymer films with tunable chiroptical properties using small amounts of self-assembling fluorescent dye as an additive....

journal_title：Chirality

authors： Jintoku H,Ihara H

更新日期：2020-05-01 00:00:00

abstract：:The attempts of applying chiroptical spectroscopy to supramolecular chirality are reviewed with a focus on vibrational circular dichroism (VCD). Examples were taken from gels, solids, and monolayers formed by low-molecular mass weight chiral gelators. Particular attention was paid to a group of gelators with perfluoro...

journal_title：Chirality

authors： Sato H,Yajima T,Yamagishi A

更新日期：2015-10-01 00:00:00

abstract：:Fluoroquinolones are popular class of antibiotics with distinct chemical functionality. Most of them are ampholytes with one chiral center. Stereogeneic center is located either in the side ring of Gatifloxacin (GFLX) or in the quinolone core of Ofloxacin (OFLX). These two amphoteric fluoroquinolones have terminal ami...

journal_title：Chirality

authors： Hassan RM,Yehia AM,Saleh OA,El-Azzouny AA,Aboul-Enein HY

更新日期：2018-06-01 00:00:00

abstract：:Synthetic pyrethroid insecticides are chiral compounds with multiple asymmetric positions. In this study, isomers of four commonly used pyrethroids were separated at the enantiomeric level by enantioselective high-performance liquid chromatography (HPLC), and differences between enantiomers in aquatic toxicity were ch...

journal_title：Chirality

authors： Liu W,Gan JJ,Qin S

更新日期：2005-01-01 00:00:00

abstract：:The R enantiomers of some of the 2-arylpropionic acid non-steroidal antiinflammatory drugs (NSAIDs) are known to undergo metabolic chiral inversion to their more pharmacologically active antipodes. This process is drug and species dependent and usually unidirectional. The S to R chiral inversion, on the other hand, is...

journal_title：Chirality

authors： Jamali F,Lovlin R,Aberg G

更新日期：1997-01-01 00:00:00

abstract：:The impact of crystalline forces on the solid-state circular dichroism (CD) spectrum of hypothemycin (), a biologically active molecule extracted from natural sources, has been analyzed by means of time-dependent density functional theory CD calculations. Input structures were extracted from the X-ray geometry of and ...

journal_title：Chirality

authors： Pescitelli G

更新日期：2012-09-01 00:00:00

abstract：:The chiral squaramide catalysts (8-15) were synthesized, and their catalytic efficiency in the enantioselective conjugate addition of pyrazolones to nitroalkenes was described. This protocol provides excellent chemical yields (up to 93%) of chiral 5-methyl-4-(2-nitro-1-arylethyl)pyrazol-3-ol derivatives with high enan...

journal_title：Chirality

authors： Aydin AE,Culha S

更新日期：2021-01-11 00:00:00

abstract：:Although the organocatalytic direct asymmetric Michael reactions of carbonyl compounds to nitroalkenes have been investigated intensely, the Michael reaction of the thioether-based donors remains a rather undeveloped field. This work concerns the asymmetric Michael addition of aryl sulfanyl-propan-2-one to nitroalkene...

journal_title：Chirality

authors： Jiang X,Zhang B,Zhang Y,Lin L,Yan W,Wang R

更新日期：2010-07-01 00:00:00

abstract：:Gold particles covered with 1,1'-binaphthyl-2,2'-dithiol (BINAS) were prepared. Using size exclusion chromatography, it was possible for the first time to separate the sample into fractions with different sizes and colors. Transmission electron microscopy shows that the particles are very small, in the order of 1 nm o...

journal_title：Chirality

authors： Gautier C,Taras R,Gladiali S,Bürgi T

更新日期：2008-03-01 00:00:00

abstract：:About 30% of a chemically diverse set of compounds were found to separate on four polysaccharide chiral stationary phases using polar organic mobile phases. No structural features appeared to correlate to successful separations. Titrations between normal and polar organic mobile phases suggested that separation mechan...

journal_title：Chirality

authors： Lynam KG,Stringham RW

更新日期：2006-01-01 00:00:00

abstract：:Two new chiral thiosemicarbazide ligands and their Cu (II), Ni (II), Pd (II), and Zn (II) complexes were synthesized and characterized by nuclear magnetic resonance (NMR) (only for ligand), Fourier transform infrared (FT-IR), ultraviolet visible (UV-Vis), mass, and elemental analysis. The antioxidant activity of ligan...

journal_title：Chirality

authors： Başaran E,Sıcak Y,Sogukomerogullari HG,Karaküçük-Iyidoğan A,Oruç-Emre EE,Sönmez M,Öztürk M

更新日期：2019-06-01 00:00:00

abstract：:Flurbiprofen is a kind of nonsteroidal anti-inflammatory drug, which has been widely used in clinic for treatment of rheumatoid arthritis and osteoarthritis. It has been reported that S-flurbiprofen shows good performance on clinic anti-inflammatory treatment, while R-enantiomer almost has no pharmacological activitie...

journal_title：Chirality

authors： Cui X,Ding Q,Shan RN,He CH,Wu KJ

更新日期：2019-06-01 00:00:00

abstract：:Three β-keto sulfoxides (1-3) were synthesized in enantiopure form and investigated by means of circular dichroism (CD) spectroscopy, both in electronic and vibrational range (ECD, VCD), in combination with quantum chemical calculations. For compound 2, the X-ray structure was available; thus, the ECD in the solid sta...

journal_title：Chirality

authors： Górecki M,Capozzi MAM,Albano G,Cardellicchio C,Di Bari L,Pescitelli G

更新日期：2018-01-01 00:00:00

abstract：:A simple, green, and direct three-component condensation of acetophenone, aromatic aldehydes with 3-oxo-N-phenylbutanamide (acetoacetanilide) to generate some novel (1S,6R)/(1R,6S)-2-oxo-N,4,6-triarylcyclohex-3-enecarboxamide derivatives was carried out over K2 CO3 (10 mol%) with high efficiency in water/ethanol as gr...

journal_title：Chirality

authors： Mousavi SR

更新日期：2016-11-01 00:00:00

abstract：:To investigate the impacts of the widely used chiral herbicide fenoxaprop-ethyl (FE) on aquatic organisms, the enrichment, metabolism, acute toxicity, and oxidative stress of fenoxaprop-ethyl and its main metabolites fenoxaprop (FA), ethyl-2-(4-hydroxyphenoxy)propanoate (EHPP), 2-(4-hydroxyphenoxy)propanoic acid (HPPA...

journal_title：Chirality

authors： Xu Y,Jing X,Zhai W,Li X

更新日期：2020-07-01 00:00:00

abstract：:Parallel kinetic resolution of Evans' phenylglycine derived oxazolidinone using an equimolar combination of quasi-enantiomeric active esters (derived from [D,13C]-labeled 2-phenylpropionic acid) was achieved. The levels of stereocontrol were high, leading to products with predictable configurations. ...

journal_title：Chirality

authors： Coumbarides GS,Dingjan M,Eames J,Flinn A,Northen J

更新日期：2007-05-05 00:00:00

abstract：:Six enantiomeric pairs of TADDOL-s gathered in two series with either methyl (series A) or phenyl (series B) substituent in 2-position of the dioxolane ring were studied by vibrational circular dichroism (VCD). Experimental IR and VCD spectra associated with density functional theory (DFT) calculations showed that the...

journal_title：Chirality

authors： Uncuta C,Bartha E,Gherase D,Teodorescu F,Draghici C,Cavagnat D,Daugey N,Liotard D,Buffeteau T

更新日期：2010-01-01 00:00:00

abstract：:The concentration sensitivity of a racemic drug (chlorpheniramine maleate) in chiral capillary electrophoresis with electrospray ionization – mass spectrometric detection was improved ~500-fold via stacking. Enantiomeric separation was achieved through the use of a neutral chiral pseudostationary phase (2-hydroxpropyl...

journal_title：Chirality

authors： Wuethrich A,Haddad PR,Quirino JP

更新日期：2014-11-01 00:00:00

abstract：:A simple high-yield three-steps route to optically active 4-hydroxymethyl-3-(1H-indolyl)oxazolidin-2-ones from (S)-glycidol is described. The key intermediates (R)-oxiran-2-ylmethyl 1H-indol-4/-5-ylcarbamates are obtained in high yields from (S)-glycidol. These are readily transformed to oxazolidin-2-ones, very intere...

journal_title：Chirality

authors： Chiummiento L,Funicello M,Tramutola F

更新日期：2012-04-01 00:00:00

abstract：:The optically active mixed-ligand fac(S)-tris(thiolato)rhodium(III) complexes, ΔL -fac(S)-[Rh(aet)2 (L-cys-N,S)](-) (aet = 2-aminoethanethiolate, L-cys = L-cysteinate) () and ΔLL -fac(S)-[Rh(aet)(L-cys-N,S)2 ](2-) were newly prepared by the equatorial preference of the carboxyl group in the coordinated L-cys ligand. T...

journal_title：Chirality

authors： Aizawa S,Tsubosaka S

更新日期：2016-01-01 00:00:00

abstract：:The assignment of the absolute configuration of novel anti-inflammatory pyrrole derivatives has been accomplished by a combined strategy based on independent physical methods. The key step of our stereochemical characterization approach is the production at mg-scale of enantiomerically pure forms by HPLC on Chiralpak ...

journal_title：Chirality

authors： Biava M,Cirilli R,Fares V,Ferretti R,Gallinella B,La Torre F,Poce G,Porretta GC,Supino S,Villani C

更新日期：2008-06-01 00:00:00

abstract：:We introduce a method to detect the activity of ion channels and pores with circular dichroism (CD) spectroscopy. G-quartets obtained by potassium templated self-assembly of 5'-guanosine monophosphate (GMP) are used as CD probes, the bee-toxin melittin as representative pore and gramicidin A as representative ion chan...

journal_title：Chirality

authors： Hennig A,Matile S

更新日期：2008-09-01 00:00:00

abstract：:Bis(diamido)-bridged basket resorcin[4]arene (all-S)-1 and its (all-R)-1 enantiomer proved able to interact with 2'-deoxycytidine (2) and pyrimidine nucleoside analogs in dimethyl sulfoxide (DMSO) solution. In such a solvent, the resorcinarene hosts adopt a preferential 1,3-alternate-like conformation, with a larger c...

journal_title：Chirality

authors： D'Acquarica I,Calcaterra A,Sacco F,Balzano F,Aiello F,Tafi A,Pesci N,Uccello-Barretta G,Botta B

更新日期：2013-12-01 00:00:00

abstract：:The influence of latent heat dissipated by the crystallization of 1,1'-binaphthyl in its supercooled molten state on the chiral symmetry breaking transition was investigated. Temperature change in the crystallization system was monitored by infrared thermocamera. Temperature rise due to the dissipation of latent heat ...

journal_title：Chirality

authors： Asakura K,Hayashi M,Osanai S

更新日期：2003-03-01 00:00:00

abstract：:One- and two-color, mass selected R2PI spectra of the S(1)<--S(0) transitions in the bare (+)-(R)-1-phenyl-1-ethanol (E(R)) and its complexes with different solvent molecules (solv) (-)-(R)-2-butanol (B(R)) or (+)-(S)-2-butanol (B(S)) and (-)-(R)-2-butylamine (A(R)) or (+)-(S)-2-butylamine (A(S)), have been recorded a...

journal_title：Chirality

authors： Giardini Guidoni A,Piccirillo S,Scuderi D,Satta M,Di Palma TM,Speranza M,Filippi A,Paladini A

更新日期：2001-01-01 00:00:00

abstract：:Racemic ketoconazole (KTZ) was the first orally active azole antifungal agent used in clinical practice and has become widely used in the treatment of mucosal fungal infections associated with AIDS immunosuppression and cancer chemotherapy. However, the use of KTZ has been limited because of adverse drug-drug interact...

journal_title：Chirality

authors： Dilmaghanian S,Gerber JG,Filler SG,Sanchez A,Gal J

更新日期：2004-02-01 00:00:00

abstract：:Chiral fungicide prothioconazole has a wide range of antifungal spectrum; however, little research has been conducted to evaluate prothioconazole on an enantiomeric level. Five target pathogens and three common aquatic organisms were tested for the enantioselective bioactivity and toxicity of prothioconazole in this w...

journal_title：Chirality

authors： Zhai W,Zhang L,Cui J,Wei Y,Wang P,Liu D,Zhou Z

更新日期：2019-06-01 00:00:00

abstract：:Massarigenin A (1) and papyracillic acids A (2) and B (3) were isolated from the endophytic fungus Microsphaeropsis sp. Their structures were elucidated by multidimensional nuclear magnetic resonance spectroscopy; the structure of massarigenin A (1) was also confirmed by X-ray crystallography. The absolute configurati...

journal_title：Chirality

authors： Hussain H,Ahmed I,Schulz B,Draeger S,Flörke U,Pescitelli G,Krohn K

更新日期：2011-09-01 00:00:00

abstract：:Analogs of the opioid peptide [D-Ala8]dynorphin A-(1-11)NH2 containing optically pure (R)- and (S)-2-aminotetralin-2-carboxylic acid (Atc) in position 4 were synthesized and evaluated for opioid receptor affinity. These peptides are the first reported dynorphin A analogs containing a conformationally constrained amino...

journal_title：Chirality

authors： Aldrich JV,Zheng QI,Murray TF

更新日期：2001-01-01 00:00:00

abstract：:Cyclic triamides bearing amidino groups at the meta position of the phenyl rings were synthesized, and their conformational properties in the crystal and in solution were examined. Compound exists as a capsule-type dimer of the enantiomers with a bowl-shaped syn conformation in the crystal state. Compound exists mainl...

journal_title：Chirality

authors： Nishiyama S,Urushibara K,Masu H,Azumaya I,Kagechika H,Tanatani A

更新日期：2015-08-01 00:00:00