Abstract:
:A simple, green, and direct three-component condensation of acetophenone, aromatic aldehydes with 3-oxo-N-phenylbutanamide (acetoacetanilide) to generate some novel (1S,6R)/(1R,6S)-2-oxo-N,4,6-triarylcyclohex-3-enecarboxamide derivatives was carried out over K2 CO3 (10 mol%) with high efficiency in water/ethanol as green solvent at room temperature. This protocol proceeded via Claisen-Schmidt condensation and Michael addition. The present methodology offers several advantages, such as short reaction time, high yield, more readily available and inexpensive materials, more environmentally friendly, no need for column chromatography, simple work-up procedure, and the absence of volatile and hazardous organic solvents.
journal_name
Chiralityjournal_title
Chiralityauthors
Mousavi SRdoi
10.1002/chir.22653subject
Has Abstractpub_date
2016-11-01 00:00:00pages
728-736issue
11eissn
0899-0042issn
1520-636Xjournal_volume
28pub_type
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