Abstract:
:The first direct asymmetric synthetic preparation of trifluoro-1-(indol-3-yl)ethanols (TFIEs) is described by an enantioselective organocatalytic method from indoles and inexpensive trifluoroacetaldehyde methyl hemiacetal. The reaction is catalyzed by hydroquinine to produce TFIEs in an almost quantitative yield and with enantioselectivities up to 75% at room temperature. The enantioselectivity is strongly dependent on the concentration of substrates and catalyst due to the competitive noncatalyzed reaction.
journal_name
Chiralityjournal_title
Chiralityauthors
Borkin DA,Landge SM,Török Bdoi
10.1002/chir.20982subject
Has Abstractpub_date
2011-09-01 00:00:00pages
612-6issue
8eissn
0899-0042issn
1520-636Xjournal_volume
23pub_type
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