Abstract:
:We present a new concept of synthesis for preparation of molecularly imprinted polymers using a functionalized initiator to replace the traditional functional monomer. Using propranolol as a model template, a carboxyl-functionalized radical initiator was demonstrated to lead to high-selectivity polymer particles prepared in a standard precipitation polymerization system. When a single enantiomer of propranolol was used as template, the imprinted polymer particles exhibited clear chiral selectivity in an equilibrium binding experiment. Unlike the previous molecular imprinting systems where the active free radicals can be distant from the template-functional monomer complex, the method reported in this work makes sure that the actual radical polymerization takes place in the vicinity of the template-associated functional groups. The success of using functional initiator to synthesize molecularly imprinted polymers brings in new possibilities to improve the functional performance of molecularly imprinted synthetic receptors.
journal_name
Chiralityjournal_title
Chiralityauthors
Liu W,Holdsworth C,Ye Ldoi
10.1002/chir.23167subject
Has Abstractpub_date
2020-03-01 00:00:00pages
370-377issue
3eissn
0899-0042issn
1520-636Xjournal_volume
32pub_type
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