Abstract:
:C2 -symmetric N,N-bis(phosphinomethyl)amines were prepared by the thermal reaction of aromatic aldehydes with ammonia and hypophosphorus acid as previously described. Both enantiomers of C2 -symmetric N,N-bis(phosphinomethyl)amine were obtained in a high enantiomeric purity through the diastereomeric salt formation with (-)-quinine, and subsequent fractional crystallization. X-ray crystallographic analysis of one of the diastereomeric salts clearly revealed that (-)-quinine could be an efficient resolving agent for obtaining the single enantiomer (R,R)-N,N-bis(phosphinomethyl)amine.
journal_name
Chiralityjournal_title
Chiralityauthors
Kaboudin B,Faghihi MR,Kazemi F,Yokomatsu Tdoi
10.1002/chir.22391subject
Has Abstractpub_date
2015-01-01 00:00:00pages
71-4issue
1eissn
0899-0042issn
1520-636Xjournal_volume
27pub_type
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