Abstract:
:High-performance liquid chromatography (HPLC) is a powerful method in the area of chiral separation. In this study, a method of HPLC using carboxymethyl-β-cyclodextrin (CM-β-CD) as chiral selector was developed for enantioseparation of nine indanone and tetralone derivatives. The separation was performed on a conventional C18 column. The optimal mobile phase was a mixture of methanol and 0.05 mol/L phosphate buffer at pH 1.8 (55:45, v/v) containing 22.9 mmol/L CM-β-CD. Under such conditions, the resolutions of all analytes were over 1.8 except for Compound F. The results of the study indicate the presence of a complex with 1:1 stoichiometry of the inclusion complex. In addition, it can be inferred from thermodynamic analysis that the behavior of formation of the inclusion complex and enantioseparation occurred simultaneously, while they were driven by different forces. The effect of analyte structure is also discussed.
journal_name
Chiralityjournal_title
Chiralityauthors
Hu X,Guo X,Sun S,Zhu B,Yu J,Guo Xdoi
10.1002/chir.22665subject
Has Abstractpub_date
2017-01-01 00:00:00pages
38-47issue
1eissn
0899-0042issn
1520-636Xjournal_volume
29pub_type
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