Abstract:
:Ibuprofen was used to demonstrate that isolated rat hepatocytes offer a suitable in vitro model to investigate the metabolic chiral inversion of anti-inflammatory 2-arylpropionic acids (profens). The inversion of the pharmacologically inactive (-)-(R)-ibuprofen to the active (+)-(S)-ibuprofen was shown to obey apparent first-order kinetics during 5 h and to increase linearly with increasing hepatocyte concentration up to 4 x 10(5) cells/ml. No elimination of (R)-ibuprofen by routes other than inversion was seen, whereas the elimination of (S)-ibuprofen appeared to be saturable.
journal_name
Chiralityjournal_title
Chiralityauthors
Müller S,Mayer JM,Etter JC,Testa Bdoi
10.1002/chir.530020203subject
Has Abstractpub_date
1990-01-01 00:00:00pages
74-8issue
2eissn
0899-0042issn
1520-636Xjournal_volume
2pub_type
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