解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Occlusion of a coronary artery if maintained for longer period of time results in damage of the cardiac tissue. However, restoration of blood flow to previously ischemic tissue can itself induce further cardiac damage, a phenomenon known as myocardial reperfusion injury. Cardiac homoeostasis is supported by a network ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1352
更新日期:2015-02-01 00:00:00
abstract::The pathophysiology of some inflammatory arterial diseases (such as vasculitis, atherogenesis and aneurysms) has been widely investigated in the last decades. Among different soluble molecules, proinflammatory cytokines (such as TNF-α, IL-1 and IL-6) were shown to trigger critical pathways regulating these arterial di...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1344
更新日期:2015-01-01 00:00:00
abstract::Changes in the status of DNA methylation are one of the most common molecular alterations in human neoplasia. We aimed to identify epigenetic molecular markers in serum for early detection of breast cancer. Authors analyzed retrospectively the methylation status of RARβ2 and APC genes in serum samples from 121 breast ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1346
更新日期:2015-01-01 00:00:00
abstract::In this study, the impact of pancreatic cancer cell interaction with macrophages on the differentiation and function of macrophages and the behaviors of pancreatic cancer cells in vitro is evaluated. The expression of immunocompetent cell-associated markers in 22 pancreatic cancer specimens was characterized by immuno...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1336
更新日期:2014-12-01 00:00:00
abstract::Advanced glycation end-products comprise a complex and heterogeneous group of compounds that have been implicated in diabetes-related complications. The importance of the Maillard reaction is depicted by the formation of reactive intermediate products known as α-oxoaldehydes, such as 3-deoxyglucosone (3-DG). This prod...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1318
更新日期:2014-10-01 00:00:00
abstract::Deletion of tumor suppressor gene, lethal(2)giant larvae [l(2)gl], leads to brain tumor in Drosophila melanogaster at larval stage of development and severe brain dysplasia in mice. We have studied the effect of two potential antitumor drugs artemisinin and curcumin in the perspective of inhibiting l(2)gl brain tumor....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1284
更新日期:2014-07-01 00:00:00
abstract::Lysosomal storage disorders (LSDs) are inherited metabolic diseases caused by deficiencies in lysosomal proteins, which result in accumulation of undegraded metabolites and disruption of lysosomal proteostasis. Despite significant progress in the molecular genetics and biochemistry underlying the cellular pathogenesis...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1288
更新日期:2014-07-01 00:00:00
abstract::The invasion and chemoresistance are crucial causes of morbidity and relapse for cancer patients. Axl is implicated in the modulation of cell invasion, cancer metastasis, and chemosensitivity in human breast carcinoma cell lines. Both breast cancer cell lines and tissues displayed increased expression of Axl, and it o...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1285
更新日期:2014-07-01 00:00:00
abstract::The current landscapes of novel therapeutic approaches rely mostly on gene-targeted technologies, enabling to fight rare genomic diseases, from infections to cancer and hereditary diseases. Although, reaching the action-site for this novel treatments requires to deliver nucleic acids, or other macromolecules into cell...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1257
更新日期:2014-03-01 00:00:00
abstract::Calcium-sensing receptor (CaSR) contributes to maintain homeostatic levels of extracellular calcium. In addition, CaSR controls other cellular activities such as proliferation and migration, particularly in cells not related to extracellular calcium homeostasis, potentially by cross-talking with parallel signaling pat...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1232
更新日期:2013-12-01 00:00:00
abstract::In this article, the experiments used to construct the ambient pH-signaling network involved in the secretion of enzymes by filamentous fungi have been reviewed, focusing on the phosphate-repressible phosphatases in Aspergillus nidulans. Classic and molecular genetics have been used to demonstrate that proteolysis of ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1217
更新日期:2013-11-01 00:00:00
abstract::How cells regulate Gq efficacy (initiation and termination of Gq signaling) to effect response remains a central question in pharmacology and drug discovery. Phospholipase C-β1 (PLC-β1) is an effector and a GTPase activating protein (GAP) specific to Gαq. The physiological function of PLC-β1 GAP remains unclear and co...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1218
更新日期:2013-11-01 00:00:00
abstract::Shiga toxin (Stx) producing Escherichia coli (STEC) is responsible to bloody diarrhea (hemorrhagic colitis) and the hemolytic uremic syndrome (HUS). STEC strains carry inducible lambda phages integrated into their genomes that encode Stx 1 and/or 2, with several allelic variants each one. O157:H7 is the serotype that ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1206
更新日期:2013-10-01 00:00:00
abstract::S-Nitrosation is rapidly emerging as a regulatory mechanism in vascular biology, with particular importance in the onset of hyperpermeability induced by pro-inflammatory agents. This review focuses on the role of endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) in regulating S-Nitrosation of adherens...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1204
更新日期:2013-10-01 00:00:00
abstract::Insulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase Akt/mammalian target of rapamycin (mTOR), Ras/Raf/extracellular signal-regulated kinase (ERK), and phosph...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1172
更新日期:2013-07-01 00:00:00
abstract::In this article, we discuss single molecule observation of rotational catalysis by E. coli ATP synthase (F-ATPase) using small gold beads. Studies involving a low viscous drag probe showed the stochastic properties of the enzyme in alternating catalytically active and inhibited states. The importance of subunit intera...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1134
更新日期:2013-03-01 00:00:00
abstract::Since about 60 years a phenomenon now called permeability transition is known in mitochondria. It involves a large pore in the inner mitochondrial membrane, the permeability transition pore (PTP) whose molecular structure is still unknown. Year after year, new hypotheses have been developed how this pore could look li...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1130
更新日期:2013-03-01 00:00:00
abstract::A large amount of evidence suggests a pathogenic link between cholesterol homeostasis dysregulation and Alzheimer's disease (AD). In cell culture systems, the production of amyloid-β (Aβ) is modulated by cholesterol, and studies on animal models have consistently demonstrated that hypercholesterolemia is associated wi...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1091
更新日期:2012-12-01 00:00:00
abstract::Alzheimer's disease (AD) is a devastating neurodegenerative disorder that results in loss of memory and cognitive function, eventually leading to dementia. A key neuropathological event in AD is the cerebral accumulation of senile plaques formed by aggregates of amyloid-β-peptides (Aβ). Aβ results from two sequential ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1099
更新日期:2012-12-01 00:00:00
abstract::Calcineurin (CN) is the only serine/threonine specific protein phosphatase regulated by Ca(2+) /calmodulin (CaM), which is composed of catalytic A subunit (CNA) and regulatory B subunit (CNB). Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is an essential component in the Toll like receptors and TNF ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1060
更新日期:2012-09-01 00:00:00
abstract::In vivo site-directed mutagenesis by single-stranded deoxyribonucleic acid recombineering is a facile method to change the color of fluorescent proteins (FPs) without cloning. Two different starting alleles of GFP were targeted for mutagenesis: gfpmut3* residing in the Escherichia coli genome and egfp carried by a bac...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1041
更新日期:2012-08-01 00:00:00
abstract::Ovarian cancer (OC) is one of the most lethal gynaecological cancers, which usually has a poor prognosis due to late diagnosis. A large percentage of the OC cell population is in a nonproliferating and quiescent stage, which poses a barrier to success when using most chemotherapeutic agents. Recent studies have shown ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1035
更新日期:2012-07-01 00:00:00
abstract::Tumstatin is a candidate tumor suppressor that plays an important role in tumor growth and angiogenesis. The purpose of this study was to evaluate the correlation between tumstatin-mRNA expression and the clinicopathologic characteristics, tumor angiogenesis, outcome of patients with non-small cell lung cancer (NSCLC)...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1016
更新日期:2012-05-01 00:00:00
abstract::We hypothesize that the various, previously reported, reactivities of neuroglobin with redox partners and oxygen provide for the establishment of a redox cycle within cells, such as neurons and retinal rod cells. Using native cell lysates, from cultured human cells of neuronal origin, we have estimated the rate of red...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.566
更新日期:2012-05-01 00:00:00
abstract::Depurinating DNA adducts formed by aromatic hydrocarbons and catechol estrogen quinones play a major role in cancer initiation. Most of these adducts depurinate instantaneously, but some guanine adducts depurinate from DNA with half-lives of hours. We report here, that after 10 h at 37 °C, reaction of estradiol-3,4-qu...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.586
更新日期:2012-02-01 00:00:00
abstract::Antibiotic resistance in Acinetobacter spp., particularly Acinetobacter baumannii, is increasing rapidly. A. baumannii possesses two intrinsic β-lactamase genes, in addition to weak permeability and efflux systems, that together confer a natural reduced susceptibility to antibiotics. In addition, numerous acquired mec...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.532
更新日期:2011-12-01 00:00:00
abstract::During the hand plate development, the processes of cell differentiation and control of cell death are relevant to ensure a correct shape of the limb. The progenitor cell pool that later will differentiate into cartilage to form the digits arises from undifferentiated mesenchymal cells beneath the apical ectodermal ri...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.563
更新日期:2011-10-01 00:00:00
abstract::T cell (TC) activation requires the coordinated signaling of the T cell receptor (TCR) and coreceptor molecules, allowing TCs to respond to lower degrees of TCR occupancy. Coreceptor molecules set the threshold for TC activation by controlling different regulatory signaling loops. The Cbl family members prevent undesi...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.554
更新日期:2011-10-01 00:00:00
abstract::Magnetic targeting has shown promise to improve the efficacy and safety of different classes of therapeutic agents by enabling their active guidance to the site of disease and minimizing dissemination to nontarget tissues. However, its translation into clinic has proven difficult because of inherent limitations of tra...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.479
更新日期:2011-08-01 00:00:00
abstract::In this review we discuss the limited efficacy for current pharmacological agents used in prophylaxis and treatment of thrombosis and highlight targeted delivery of anti-thrombotic agents to fibrin, platelets, red blood cells and endothelium. ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.474
更新日期:2011-08-01 00:00:00
abstract::Recently, cytochrome P450 170A1 (CYP170A1) has been found to be a bifunctional protein, which catalyzes both monooxygenase activity and terpene synthase activity by two distinct active sites in the well-established P450 protein structure. Therefore, CYP170A1 is identified clearly as a moonlighting protein. The known a...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.501
更新日期:2011-07-01 00:00:00
abstract::The posttranscriptional regulation of miRNAs is important for organism development. To investigate the role of miRNAs in angiogenesis, we performed a loss-of-function screening assay in human umbilical vein endothelial cells (HUVECs) and found that knockdown of 7 miRNAs (miR-95a, miR-126, miR-129, miR-137, miR-139, mi...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.486
更新日期:2011-07-01 00:00:00
abstract::Cooperative effects in ligand binding and dissociation kinetics are much less investigated than steady state kinetics or equilibrium binding. Nevertheless, cooperativity in ligand binding leads necessarily to characteristic properties with respect to kinetic properties of the system. In case of positive cooperativity ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.459
更新日期:2011-05-01 00:00:00
abstract::Red blood cells of yellow-spotted river turtles (Podocnemis unifilis, Pleurodira, Chelonia, REPTILIA) have two hemoglobin (Hb) components, Hb A and Hb D. We purified the hemoglobin component homologous to amniote (reptiles, birds, and mammals) adult Hb A which comprises two identical α(A) -globin polypeptides and two ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.429
更新日期:2011-03-01 00:00:00
abstract::Heparin and its various derivatives affect cancer progression in humans. In this study, we show that heparin uptaken intracellularly by melanoma cells activated a signaling cascade, which in turn inhibited melanoma cell adhesion and migration. The reduced ability of M5 cells to adhere onto the fibronectin (FN) substra...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.421
更新日期:2011-02-01 00:00:00
abstract::Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to this process. Its activity is modulated in a coordinated manner via a ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.411
更新日期:2011-01-01 00:00:00
abstract::Over the past decade, following the discovery of the human heme protein neuroglobin, many studies have searched for evidence for this protein's mechanism of action. Much data has accrued showing that high levels of neuroglobin will protect cells from apoptotic cell death, following a wide range of challenges. Various ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.405
更新日期:2010-12-01 00:00:00
abstract::Small noncoding RNAs are key controllers of cellular function, and their deregulation can lead to cancer development and metastatic evolution. This review summarizes the most important examples of small RNAs involved in human cancer and discusses their clinical use as biomarkers and drug targets for diagnosis, prognos...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.399
更新日期:2010-12-01 00:00:00
abstract::Transketolase (TK, EC 2.2.1.1), the key enzyme of the non-oxidative branch of pentose phosphate pathway of hydrocarbon transformation, plays an important role in a system of substrate rearrangement between pentose shunt and glycolysis, acting as a reversible link between the two metabolic pathways. In addition, it sup...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.395
更新日期:2010-11-01 00:00:00
abstract::Cellular nucleic acid binding protein (CNBP) has been implicated in vertebrate craniofacial development and in myotonic dystrophy type 2 (DM2) and sporadic inclusion body myositis (sIBM) human diseases. In these seemingly unrelated biological processes, CNBP appears to be involved in controlling cell death and prolife...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.379
更新日期:2010-10-01 00:00:00