Abstract:
:Occlusion of a coronary artery if maintained for longer period of time results in damage of the cardiac tissue. However, restoration of blood flow to previously ischemic tissue can itself induce further cardiac damage, a phenomenon known as myocardial reperfusion injury. Cardiac homoeostasis is supported by a network of direct and indirect interactions between cardiomyocytes and resident cell types such as fibroblasts, adipocytes, and endothelial cells or invading blood cells. This review will discuss the role of the cellular interplay in ischemia-reperfusion injury from a cardiomyocyte-centered view, although we are aware that other cellular interactions are equally important. We will try to work out currently unresolved questions and potential future directions in the field.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Rohrbach S,Troidl C,Hamm C,Schulz Rdoi
10.1002/iub.1352subject
Has Abstractpub_date
2015-02-01 00:00:00pages
110-9issue
2eissn
1521-6543issn
1521-6551journal_volume
67pub_type
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