Bacterial wobble modifications of NNA-decoding tRNAs.

Abstract:

:Nucleotides of transfer RNAs (tRNAs) are highly modified, particularly at the anticodon. Bacterial tRNAs that read A-ending codons are especially notable. The U34 nucleotide canonically present in these tRNAs is modified by a wide range of complex chemical constituents. An additional two A-ending codons are not read by U34-containing tRNAs but are accommodated by either inosine or lysidine at the wobble position (I34 or L34). The structural basis for many N34 modifications in both tRNA aminoacylation and ribosome decoding has been elucidated, and evolutionary conservation of modifying enzymes is also becoming clearer. Here we present a brief review of the structure, function, and conservation of wobble modifications in tRNAs that translate A-ending codons. © 2019 IUBMB Life, 2019 © 2019 IUBMB Life, 71(8):1158-1166, 2019.

journal_name

IUBMB Life

journal_title

IUBMB life

authors

Nilsson EM,Alexander RW

doi

10.1002/iub.2120

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

1158-1166

issue

8

eissn

1521-6543

issn

1521-6551

journal_volume

71

pub_type

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