Abstract:
:The yeast Saccharomyces cerevisiae is an excellent model for gaining insights into the molecular basis of human mitochondrial disorders, particularly those resulting from impaired mitochondrial metabolism. Yeast is a very well characterized system and most of our current knowledge about mitochondrial biogenesis in humans derives from yeast genetics and biochemistry. Systematic yeast genome-wide approaches have allowed for the identification of human disease genes. In addition, the functional characterization of a large number of yeast gene products resident in mitochondria has been instrumental for the later identification and characterization of their human orthologs. Here I will review the molecular and biochemical characterization of several mitochondrial diseases that have been ascribed to mutations in genes that were first found in yeast to be necessary for the assembly of the mitochondrial respiratory chain. The usefulness of yeast as a model system for human mitochondrial disorders is evaluated.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Barrientos Adoi
10.1002/tbmb.718540876keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
83-95issue
2eissn
1521-6543issn
1521-6551journal_volume
55pub_type
杂志文章,评审相关文献
IUBMB LIFE文献大全abstract::Fascin actin-bundling protein 1 (FSCN1) is an evolutionarily conserved actin-bundling protein that plays a critical role in cell migration, motility, adhesion, and cellular interactions. Although multiple clinical studies have implicated the expression of FSCN1 in laryngeal squamous cell carcinoma (LSCC) progression, ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2121
更新日期:2019-11-01 00:00:00
abstract::Papillary thyroid cancer (PTC) is the most common form of thyroid cancer, comprising 80% of all thyroid malignancies. The phosphoinositide-3-kinase-protein kinase B/Akt (PI3K-PKB/Akt) pathway is a main pathway in control of cell growth. Activated mTOR and Akt are involved in the development and progression of the PTC....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2388
更新日期:2020-12-01 00:00:00
abstract::Stem cells from human exfoliated deciduous teeth (SHEDs) are highly proliferative, clonogenic, and multipotent stem cells with a neural crest cell origin. This property could be a desirable option for potential therapeutic applications. In this study, we focus on the effects of Rho kinase inhibitors Y-27632 and Noggin...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2208
更新日期:2020-04-01 00:00:00
abstract::We propose a new hypothesis for the molecular mechanism by which neuroglobin exerts its protective effect in hypoxia-induced cell death. Our recent observation of a very rapid electron-transfer reaction between ferrous neuroglobin and ferric cytochrome c is central to this hypothesis. In contrast to previously suggest...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.35
更新日期:2008-06-01 00:00:00
abstract::The amino acids glutamate and gamma-aminobutyric acid (GABA) have primarily been characterized as the most prevalent excitatory and inhibitory, respectively, neurotransmitters in the vertebrate central nervous system. However, the role of these signaling molecules extends far beyond the synapse. GABA, glutamate, and t...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.185
更新日期:2009-05-01 00:00:00
abstract::The rat organic anion transporter 3 (rOAT3) has recently been identified as the third isoform of the OAT family. The mechanisms that regulate rOAT3's functions remain to be elucidated. rOAT3 contributes for moving a number of negatively charged organic compounds between cells and their extracellular milieu. Caveolin (...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540500104750
更新日期:2005-02-01 00:00:00
abstract::Recently the crystal structure of creatine kinase from Torpedocalifornica was determined to 2.1 A. The dimeric structure revealed two different forms in the unit cell: one monomer was bound to a substrate, MgADP, and the other monomer was bound to a transition-state analogue complex composed of MgADP, nitrate and crea...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540500091999
更新日期:2005-04-01 00:00:00
abstract::Specific RNAs can function as sinks for endogenous miRNAs, known as competing endogenous RNAs (ceRNAs). Here, we confirm a miR-124 mediated ceRNA crosstalk between LAMC1 and CD151 in hepatocellular carcinoma (HCC). miR-124 negatively regulates LAMC1 expression through two miRNA binding sites within its 3' untranslated...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1642
更新日期:2017-08-01 00:00:00
abstract::Heart disease is the most common cause of morbidity and mortality in Western society and the incidence is projected to increase significantly over the next few decades as our population ages. Heart failure occurs when the heart is unable to pump blood at a rate to commensurate with tissue metabolic requirements and re...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540214312
更新日期:2002-08-01 00:00:00
abstract::Circular RNAs (circRNAs) are novel noncoding RNAs (ncRNAs) with covalently closed-loop structures that play an essential regulatory role in diverse malignancies, including esophageal squamous cell cancer (ESCC). Circ_0000654 expression in ESCC and its mechanism of action remains unclear. Real-time PCR (RT-PCR) was emp...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2202
更新日期:2020-03-01 00:00:00
abstract::Elevated homocysteine levels are known to be a risk factor for congenital cardiac septal defects (CCSDs), but the mechanism underlying this effect is unknown. The genetic variants that were significantly associated with circulating homocysteine concentrations have been systematically identified through the genome-wide...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1651
更新日期:2017-09-01 00:00:00
abstract::In tsRSV-infected NRK (tsNRK) cells, pp60(v-src) reactivation by temperature-shift from a nonpermissive temperature, 39 C, to a permissive one, 32 degrees C, induced the production of inositol phosphates (IPt) and phosphatidylethanol (PEt). This was accompanied by an increase in membrane-associated protein kinase C (P...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803467
更新日期:1999-07-01 00:00:00
abstract::Hepatocyte mitochondrial aquaporin-8 (mtAQP8) works as a multifunctional membrane channel protein that facilitates the uptake of ammonia for its detoxification to urea as well as the mitochondrial release of hydrogen peroxide. Since early oligonucleotide microarray studies in liver of cholesterol-fed mice showed an AQ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1615
更新日期:2017-05-01 00:00:00
abstract::Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to this process. Its activity is modulated in a coordinated manner via a ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.411
更新日期:2011-01-01 00:00:00
abstract::Since about 60 years a phenomenon now called permeability transition is known in mitochondria. It involves a large pore in the inner mitochondrial membrane, the permeability transition pore (PTP) whose molecular structure is still unknown. Year after year, new hypotheses have been developed how this pore could look li...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1130
更新日期:2013-03-01 00:00:00
abstract::Nucleotides of transfer RNAs (tRNAs) are highly modified, particularly at the anticodon. Bacterial tRNAs that read A-ending codons are especially notable. The U34 nucleotide canonically present in these tRNAs is modified by a wide range of complex chemical constituents. An additional two A-ending codons are not read b...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2120
更新日期:2019-08-01 00:00:00
abstract::During the hand plate development, the processes of cell differentiation and control of cell death are relevant to ensure a correct shape of the limb. The progenitor cell pool that later will differentiate into cartilage to form the digits arises from undifferentiated mesenchymal cells beneath the apical ectodermal ri...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.563
更新日期:2011-10-01 00:00:00
abstract::Members of the GATA family of transcription factors play key roles in the differentiation of specific cell lineages by regulating the expression of target genes. Three GATA factors play distinct roles in hematopoietic differentiation. In order to better understand how these GATA factors function to regulate genes thro...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2195
更新日期:2020-01-01 00:00:00
abstract::Exosomes are nano-sized extracellular vesicles containing a cell-specific biologically active cargo of proteins and genetic materials. Exosomes are constitutively released from almost all cell-types and affect neighboring or distant cells through a complex intercellular exchange of the genetic information and/or regul...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2396
更新日期:2020-12-01 00:00:00
abstract::Pancreatic islet beta-cells are poised to generate metabolic messengers in the mitochondria that link glucose metabolism to insulin exocytosis. This is accomplished through the tight coupling of glycolysis to mitochondrial activation. The messenger molecules ATP and glutamate are produced after the metabolism of glyco...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/152165400410236
更新日期:2000-05-01 00:00:00
abstract::The last 15 years of effort in understanding bacterial DNA replication and repair has identified that the donut shaped beta2 sliding clamp is harnessed by very functionally different DNA polymerases throughout the lifecycle of the bacterial cell. Remarkably, the sites of binding of these polymerases, in most cases, ap...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540500138246
更新日期:2005-06-01 00:00:00
abstract::Cartilage engineering is one challenging issue in regenerative medicine. Low oxygen tension or hypoxia inducible factor-1 (HIF-1α) gene therapy are promising strategies in the field of cartilage repair. Previously, we showed that hypoxia and its mediator HIF-1 regulate matrix genes expression (collagens and aggrecan)....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1539
更新日期:2016-09-01 00:00:00
abstract::N-Acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a critical negative regulator of fibrosis development in the liver. However, its extremely short half-life in vivo greatly compromises its potential applications. Here, we report an Ac-SDKP analog peptide with d-amino acid replacement (Ac-SDD KD P). The stability of A...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2037
更新日期:2019-09-01 00:00:00
abstract::The cancer microenvironment and the interactions between cancer and surrounding tissue cells are thought to play a pivotal role in tumor development and progression. Glycosaminoglycans (GAGs)/proteoglycans (PGs) are major constituents of the extracellular matrix, the composition of which may affect various cellular fu...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.70
更新日期:2008-05-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is a common malignant cancer with unfavorable prognosis, and the epithelial-to-mesenchymal transition (EMT) is a critical contributor to OSCC metastasis. Recently, we have shown that sirtuin 7 (Sirt7) is associated with EMT and OSCC metastasis by acetylating small mother against dec...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2426
更新日期:2020-12-16 00:00:00
abstract::We investigated signaling pathways leading to tumor necrosis factor (TNF) alpha-induced intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 expression in chondrosarcoma cells, and determined the functional significance of their expression by examining Jurkat T cell adhesion. TNFalpha ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540215674
更新日期:2002-11-01 00:00:00
abstract::The effect of streptozotocin-induced diabetes on cholinesterases activities was studied in the retina and, for comparison, in other nervous and nonnervous tissues. Streptozotocin diabetes did not affect acetylcholinesterase activity in the retina but increased its activity in the cerebral cortex (100%) and in serum (5...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540050033140
更新日期:2000-04-01 00:00:00
abstract::Reactive oxygen and nitrogen species (ROS and RNS) have been extensively recognized as important signaling molecules implicated in physiological processes such as gene expression, cell differentiation and immune activation. Nevertheless, continuous production of these species may produce oxidative and/or nitrosative s...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540310001628717
更新日期:2003-10-01 00:00:00
abstract::Traumatic optic neuropathy is an important cause of severe vision loss. So, many attempts were performed to transplant stem cells systemically or locally to regenerate the injured retina. In this study, we investigated the effect of human umbilical cord blood mesenchymal stem cells (hUBMSCs) on histological structure,...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1608
更新日期:2017-03-01 00:00:00
abstract::Various strategies have been applied to replace the loss of cardiomyocytes in order to restore reduced cardiac function and prevent the progression of heart disease. Intensive research efforts in the field of cellular reprogramming and cell transplantation may eventually lead to efficient in vivo applications for the ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2150
更新日期:2020-01-01 00:00:00