Loop movement and catalysis in creatine kinase.

abstract：:Immune infiltration of tumors has been increasingly accepted as a prognostic factor in colon cancer. Here, we aim to develop a novel immune signature, based on estimated immune landscape from tumor transcriptomes, to predict the overall survival of patients with colon cancer. The compositions of 22 immune cell subtype...

journal_title：IUBMB life

authors： Peng D,Wang L,Li H,Cai C,Tan Y,Xu B,Le H

更新日期：2019-11-01 00:00:00

abstract：:Interplay between the apoptosis, DNA damage, and oxidative stress as a host response to dengue viral infections remains unclear. Peripheral blood mononuclear cells (PBMCs) were isolated from 60 dengue infected patients, 20 patients with febrile illness other than dengue (OFI) and 10 non-febrile illness (NFI) patients....

journal_title：IUBMB life

authors： Cherupanakkal C,Samadanam DM,Muthuraman KR,Ramesh S,Venkatesan A,Balakrishna Pillai AK,Rajendiran S

更新日期：2018-11-01 00:00:00

abstract：:Human ecto-ATPase (ecto-nucleoside triphosphate diphosphohydrolase 2 [eNTPDase2], also known as CD39L1) has been expressed and characterized in COS cells. It exhibits some unusual enzymology that is similar to a few members of this class of proteins but different from the majority of the family members. Hydrolysis of ...

journal_title：IUBMB life

authors： Hicks-Berger CA,Kirley TL

更新日期：2000-07-01 00:00:00

abstract：:Nur77 is a member of nuclear receptor superfamily that acts as a transcription factor and regulates expression of multiple genes. Subcellular localization of Nur77 protein plays an important role in the survival and cell death. In this study, we have predicted and confirmed alternatively spliced two new transcripts of...

journal_title：IUBMB life

authors： Rehman SU,Sarwar T,Husain MA,Ishqi HM,Tabish M

更新日期：2017-02-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) is linked to the etiopathogenesis of Kaposi's sarcoma, a plasma-blastic variant of Castleman's disease and primary effusion lymphoma. KSHV is related to a number of non-human primate viruses. Only a limited number of KSHV proteins are expressed in tumor cells. He...

journal_title：IUBMB life

authors： Sharp TV,Boshoff C

更新日期：2000-02-01 00:00:00

abstract：:Role of nitric oxide (NO) on the expression of organic anion transporter 2 (OAT2) located in sinusoidal domain of hepatocytes has been investigated. Effect of NO generated in vivo in rat and delivered in vitro to hepatocytes was determined. Lipopolysaccharide (LPS) and spermine NONOate (SPER/NO) were selected as the N...

journal_title：IUBMB life

authors： Cha SH,Kim HP,Jung NH,Lee WK,Kim JY,Cha YN

更新日期：2002-09-01 00:00:00

abstract：:Recent structural studies of proteins mediating membrane fusion reveal intriguing similarities between diverse viral and mammalian systems. Particularly striking is the close similarity between the transmembrane envelope glycoproteins from the retrovirus HTLV-1 and the filovirus Ebola. These similarities suggest simil...

journal_title：IUBMB life

authors： Poumbourios P,Center RJ,Wilson KA,Kemp BE,Kobe B

更新日期：1999-08-01 00:00:00

abstract：:Large inter-individual variation exists in the response to vitamin E supplementation, and this may influence the outcome of human studies. It is our hypothesis that genetic heterogeneity is an important determinant of vitamin E homeostasis. Therefore we have performed an in silico search for single nucleotide polymorp...

journal_title：IUBMB life

authors： Döring F,Rimbach G,Lodge JK

更新日期：2004-10-01 00:00:00

abstract：:In protein and RNA macromolecules, only a limited number of different side-chain chemical groups are available to function as catalysts. The myriad of enzyme-catalyzed reactions results from the ability of most of these groups to function either as nucleophilic, electrophilic, or general acid-base catalysts, and the k...

journal_title：IUBMB life

authors： Harris TK,Turner GJ

更新日期：2002-02-01 00:00:00

abstract：:In this study, the impact of pancreatic cancer cell interaction with macrophages on the differentiation and function of macrophages and the behaviors of pancreatic cancer cells in vitro is evaluated. The expression of immunocompetent cell-associated markers in 22 pancreatic cancer specimens was characterized by immuno...

journal_title：IUBMB life

authors： Meng F,Li C,Li W,Gao Z,Guo K,Song S

更新日期：2014-12-01 00:00:00

abstract：:Crude brazilin extract from Sappan wood has demonstrated strong anti tumor activity in the mouse model of human bladder carcinoma and clinical trial for intravesical therapy. Purified brazilin was confirmed the most active molecule in inhibition of bladder carcinoma T24 cells. Brazilin decreased proliferation and viab...

journal_title：IUBMB life

authors： Zhang T,Fan X,Song L,Ren L,Ma E,Zhang S,Ren L,Zheng Y,Zhang J

更新日期：2015-03-01 00:00:00

abstract：:Nasal-type natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy with poor survival outcomes that is relatively resistant to chemotherapy. N6-Methyladenosine (m6A) modification, the most prevalent modification of eukaryotic messenger RNA, is involved in the progression of various tumors. However, it is un...

journal_title：IUBMB life

authors： Ma H,Shen L,Yang H,Gong H,Du X,Li J

更新日期：2020-11-17 00:00:00

abstract：:Renal ischemia/reperfusion (I/R) is an alternation of renal hemodynamics, which results in diverse postischemic responses and eventually acute kidney injury. Although renal ischemic preconditioning (IPC) is known to protect the kidney from I/R injury, the precise renoprotective mechanisms are not completely understood...

journal_title：IUBMB life

authors： Li JR,Ou YC,Wu CC,Wang JD,Lin SY,Wang YY,Chen WY,Chen CJ

更新日期：2019-03-01 00:00:00

abstract：:The current landscapes of novel therapeutic approaches rely mostly on gene-targeted technologies, enabling to fight rare genomic diseases, from infections to cancer and hereditary diseases. Although, reaching the action-site for this novel treatments requires to deliver nucleic acids, or other macromolecules into cell...

journal_title：IUBMB life

authors： de Figueiredo IR,Freire JM,Flores L,Veiga AS,Castanho MARB

更新日期：2014-03-01 00:00:00

abstract：:Bovine Spongiform Encephalopathy (BSE) is typical of the dementias that affect both animals and man; Scrapie in sheep, Creutzfeldt-Jakob disease in man. Global efforts have been made to determine the nature of the active agents in these diseases. At present the 'protein only hypothesis' of Prusiner holds. It was a sur...

journal_title：IUBMB life

authors： Campbell PN

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:Heart diseases are common in the offspring of gestational diabetic mother (ODM). Defects in mitochondrial metabolism and autophagy may, in part, be responsible for the adverse structural and functional alterations in the heart. The principal objective of this study was to investigate cardiac mitochondrial res...

journal_title：IUBMB life

authors： Rajendran RS,Jayakumari NR,Sivasailam A,Reghuvaran AC,Pillai VV,Karunakaran J,Sreelatha HV,Manjunatha S,Gopala S

更新日期：2021-01-22 00:00:00

abstract：:Induction of apoptosis is the target of choice for modern chemotherapeutic treatment of cancer, where lack of potent "target-specific" drugs has led to extensive research on anticancer compounds from natural sources. In our study, we have used astrakurkurone, a triterpene isolated from wild edible mushroom, Astraeus h...

journal_title：IUBMB life

authors： Dasgupta A,Dey D,Ghosh D,Lai TK,Bhuvanesh N,Dolui S,Velayutham R,Acharya K

更新日期：2019-07-01 00:00:00

abstract：:5-Hydroxytryptamine 2C (5-HT2C ) receptor agonists have been suggested to possess an antipsychotic activity in several acute preclinical tests of antipsychotic drugs with low extra-pyramidal side effect liability. However, little is known about the long-term effect associated with chronic use of 5-HT2C receptor agonis...

journal_title：IUBMB life

authors： Chen W,Wang X,Yan M,Wang Y,Xie S,Li H,Li M

更新日期：2016-12-01 00:00:00

abstract：:The activation and incorporation of selenium into selenocysteine containing selenoproteins has been well established in an Escherichia coli model system but there is little specific information concerning the transport and intracellular trafficking of selenium in biological systems in general. A selenium transport rol...

journal_title：IUBMB life

authors： Self WT,Pierce R,Stadtman TC

更新日期：2004-08-01 00:00:00

abstract：:The 10th jubilee conference (IPK2019) took place on September 15-19, 2019 in Warsaw, on the Ochota campus as the IUBMB Focused Meeting entitled "Inhibitors of Protein Kinases. Kinase inhibitors in target biology and disease". ...

journal_title：IUBMB life

authors： Poznanski J,Fabbro D

更新日期：2020-06-01 00:00:00

abstract：:T cell (TC) activation requires the coordinated signaling of the T cell receptor (TCR) and coreceptor molecules, allowing TCs to respond to lower degrees of TCR occupancy. Coreceptor molecules set the threshold for TC activation by controlling different regulatory signaling loops. The Cbl family members prevent undesi...

journal_title：IUBMB life

authors： Pedraza-Alva G,Mérida LB,del Rio R,Fierro NA,Cruz-Muñoz ME,Olivares N,Melchy E,Igras V,Holländer GA,Burakoff SJ,Rosenstein Y

更新日期：2011-10-01 00:00:00

abstract：:PlncRNA-1 has been suggested to function as an oncogenic role in prostate cancer, colorectal cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma, and gastric cancer. The expression pattern of PlncRNA-1 in retinoblastoma remained unknown. Therefore, the aim of this study was to explore the clinical sig...

journal_title：IUBMB life

authors： Wang S,Liu J,Yang Y,Hao F,Zhang L

更新日期：2018-10-01 00:00:00

abstract：:Uncoupling proteins (UCPs) are regulated H+ transporters and a subfamily of the mitochondrial carrier family. Whereas UCP1 in brown adipose tissue has a well-defined role in thermogenesis, the roles of other UCPs are still tentative, such as in control of immune response, oxygen radical formation, and insulin secretio...

journal_title：IUBMB life

authors： Klingenberg M

更新日期：2001-09-01 00:00:00

abstract：:This study examined whether cell cycle regulatory proteins, such as cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors, regulate type II collagen expression and mediate interlukin-1 (IL-1beta)-induced suppression of type II collagen expression in articular chondrocytes. IL-1beta inhibited type II collagen ex...

journal_title：IUBMB life

authors： Hwang SG,Song SM,Kim JR,Park CS,Song WK,Chun JS

更新日期：2007-02-01 00:00:00

abstract：:The rat organic anion transporter 3 (rOAT3) has recently been identified as the third isoform of the OAT family. The mechanisms that regulate rOAT3's functions remain to be elucidated. rOAT3 contributes for moving a number of negatively charged organic compounds between cells and their extracellular milieu. Caveolin (...

journal_title：IUBMB life

authors： Kwak JO,Kim HW,Song JH,Kim MJ,Park HS,Hyun DK,Kim DS,Cha SH

更新日期：2005-02-01 00:00:00

abstract：:Combining two analytical techniques, HPLC and liquid secondary ion mass spectrometry, the orientation of liposomal membrane-bound melittin was analyzed through its trypsin-digested products. We found that trypsin can access all proteolytic sites of the membrane-bound melittin when the liposomes have no transmembrane p...

journal_title：IUBMB life

authors： Niu W,Wu Y,Sui SF

更新日期：2000-09-01 00:00:00

abstract：:Myocardial ischemia/reperfusion (I/R) injury greatly contributes to myocardial tissue damage in patients with coronary disease, which eventually leads to heart failure. Long noncoding RNAs (lncRNAs) have an emerging role in the process of myocardial I/R injury. Our previous work revealed the protective role of miR-374...

journal_title：IUBMB life

authors： Chen YQ,Yang X,Xu W,Yan Y,Chen XM,Huang ZQ

更新日期：2020-12-09 00:00:00

abstract：:In most organisms, productive utilization of galactose requires the highly conserved Leloir pathway of galactose metabolism. Yet, if this metabolic pathway is perturbed due to congenital deficiencies of the three associated enzymes, or an overwhelming presence of galactose, this monosaccharide which is abundantly pres...

journal_title：IUBMB life

authors： Lai K,Elsas LJ,Wierenga KJ

更新日期：2009-11-01 00:00:00

abstract：:In tsRSV-infected NRK (tsNRK) cells, pp60(v-src) reactivation by temperature-shift from a nonpermissive temperature, 39 C, to a permissive one, 32 degrees C, induced the production of inositol phosphates (IPt) and phosphatidylethanol (PEt). This was accompanied by an increase in membrane-associated protein kinase C (P...

journal_title：IUBMB life

authors： Kim BY,Kim JH,Han YJ,Ahn SC,Kang DO,Oh WK,Ko HR,Lee HS,Mheen TI,Ahn JS

更新日期：1999-07-01 00:00:00

abstract：:Prostate cancer (PCa) is considered the most common malignancy in men. The aim of this study is to assess the role of serum miR-15a and miR-16-1 expression in PCa development, diagnosis and prognosis aiming to find a specific noninvasive biomarker. This study comprised 70 patients with PCa, 70 patients complaining of ...

journal_title：IUBMB life

authors： Zidan HE,Abdul-Maksoud RS,Elsayed WSH,Desoky EAM

更新日期：2018-05-01 00:00:00