Abstract:
:In tsRSV-infected NRK (tsNRK) cells, pp60(v-src) reactivation by temperature-shift from a nonpermissive temperature, 39 C, to a permissive one, 32 degrees C, induced the production of inositol phosphates (IPt) and phosphatidylethanol (PEt). This was accompanied by an increase in membrane-associated protein kinase C (PKC) activity in the absence of exogenous growth factors. However, with serum-stimulation, the amounts of IPt and PEt at 32 degrees C were less than those at 39 degrees C. Pretreatment with PKC inhibitors, Ro-31-8220 and staurosporine, enhanced the accumulation of IPt but not of PEt at 32 degrees C. The tyrosine phosphorylation of phospholipase Cgamma1 (PLCgamma1) was increased either by serum or by pp60(v-src) reactivation. These results suggest that serum transduces its signal through PLCgamma1 mediation, and that pp60(v-src), possibly through the PKC mediation, negatively affects serum-induced PLCgamma1 activation.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Kim BY,Kim JH,Han YJ,Ahn SC,Kang DO,Oh WK,Ko HR,Lee HS,Mheen TI,Ahn JSdoi
10.1080/713803467keywords:
subject
Has Abstractpub_date
1999-07-01 00:00:00pages
85-9issue
1eissn
1521-6543issn
1521-6551journal_volume
48pub_type
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