Abstract:
:Interplay between the apoptosis, DNA damage, and oxidative stress as a host response to dengue viral infections remains unclear. Peripheral blood mononuclear cells (PBMCs) were isolated from 60 dengue infected patients, 20 patients with febrile illness other than dengue (OFI) and 10 non-febrile illness (NFI) patients. DNA damage in the PBMCs was assessed using single cell gel electrophoresis and stages of apoptosis underwent by the PBMCs were studied by Annexin-PI staining using flow cytometry. Plasma levels of malondialdehyde levels were estimated using thiobarbituric acid assay. Dengue infected individuals had showed increased DNA damage than NFI and OFI controls at the time of admission. Annexin-PI staining revealed increased frequency of apoptotic cells in dengue infected PBMCs than controls during the admission time. Similar pattern was observed in samples collected around defervescence. Within the dengue cases, percentage of live cells was higher in non-severe dengue than severe dengue at both the time points. Follow-up samples in dengue showed less number of live cells and higher percentage of apoptotic cells with respect to their baseline and this was reversed in case of OFI. Plasma malondialdehyde levels were found to be relatively higher in dengue cases than controls at admission and around defervescence. Significant positive correlation between DNA damage, apoptosis, and plasma malondialdehyde levels might pave a way for understanding the complex interactions between virus and hosts response thereby aids in identifying plausible immunopathological links contributing to disease pathogenesis. © 2018 IUBMB Life, 70(11):1133-1143, 2018.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Cherupanakkal C,Samadanam DM,Muthuraman KR,Ramesh S,Venkatesan A,Balakrishna Pillai AK,Rajendiran Sdoi
10.1002/iub.1925subject
Has Abstractpub_date
2018-11-01 00:00:00pages
1133-1143issue
11eissn
1521-6543issn
1521-6551journal_volume
70pub_type
杂志文章相关文献
IUBMB LIFE文献大全abstract::Uncoupling proteins (UCPs) mediate inducible proton conductance in the mitochondrial inner membrane. Herein, we summarize our knowledge regarding UCPs in invertebrates. Since 2001, the presence of UCPs has been demonstrated in nematodes, mollusks, amphioxi, and insects. We discuss the following important issues concer...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1535
更新日期:2016-09-01 00:00:00
abstract::Uncoupling proteins (UCPs) are regulated H+ transporters and a subfamily of the mitochondrial carrier family. Whereas UCP1 in brown adipose tissue has a well-defined role in thermogenesis, the roles of other UCPs are still tentative, such as in control of immune response, oxygen radical formation, and insulin secretio...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540152845975
更新日期:2001-09-01 00:00:00
abstract::The pathways for ligand entry and exit in myoglobin have now been well established by a wide variety of experimental results, including pico- to nano- to microsecond transient absorbance measurements and time-resolved X-ray crystallographic measurements. Trp insertions have been used to block, one at a time, the three...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540701230495
更新日期:2007-08-01 00:00:00
abstract::Cancers have a clonal origin, yet their chromosomes and genes are non-clonal or heterogeneous due to an inherent genomic instability. However, the cause of this genomic instability is still debated. One theory postulates that mutations in genes that are involved in DNA repair and in chromosome segregation are the prim...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540410001667902
更新日期:2004-02-01 00:00:00
abstract::Besides its classical mode of action through activation of specific receptors at the cell surface, fibroblast growth factor 1 (FGF1) can also cross the cellular membrane and translocate into the cytosol and further to the nucleus. The mechanism of this translocation is described partially, but the role of FGF1 inside ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1480
更新日期:2016-03-01 00:00:00
abstract::Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) is linked to the etiopathogenesis of Kaposi's sarcoma, a plasma-blastic variant of Castleman's disease and primary effusion lymphoma. KSHV is related to a number of non-human primate viruses. Only a limited number of KSHV proteins are expressed in tumor cells. He...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540050022395
更新日期:2000-02-01 00:00:00
abstract::Alkyl-dihydroxyacetonephosphate synthase (alkyl-DHAP synthase) is a peroxisomal enzyme that plays a key role in ether phospholipid biosynthesis. To determine the turnover of alkyl-DHAP synthase in several peroxisomal disorders, pulse-chase experiments were performed. In control fibroblasts, mature alkyl-DHAP synthase ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803571
更新日期:1999-12-01 00:00:00
abstract::Over the past decade, following the discovery of the human heme protein neuroglobin, many studies have searched for evidence for this protein's mechanism of action. Much data has accrued showing that high levels of neuroglobin will protect cells from apoptotic cell death, following a wide range of challenges. Various ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.405
更新日期:2010-12-01 00:00:00
abstract::Transfer RNAs require essential maturation steps to become functional. Among them, RNase P removes 5' leader sequences of pre-tRNAs. Although RNase P was long thought to occur universally as ribonucleoproteins, different types of protein-only RNase P enzymes were discovered in both eukaryotes and prokaryotes. Interest...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2062
更新日期:2019-08-01 00:00:00
abstract::Lead (Pb) is a toxic heavy metal that is harmful to humans, especially male reproductive organs. Luteolin (LUT) is a naturally occurring flavonoid with numerous biological activities. Our aim was to investigate the possible reproprotective effect of LUT against testicular deficits induced by Pb intoxication. In the pr...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2311
更新日期:2020-08-01 00:00:00
abstract::The pathogenetic mechanism of the most extensively investigated A3243G mutated tRNALeu(UUR) gene, which causes the MELAS encephalomyopathy, maternally inherited diabetes, or chronic progressive external ophlthalmoplegia, is still unresolved, despite the numerous investigations on the topic. Previous evidences presente...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/1521654031000110190
更新日期:2003-03-01 00:00:00
abstract::Transketolase (TK) is a homodimer, the simplest representative of thiamine diphosphate (ThDP)-dependent enzymes. It was first ThDP-dependent enzymes the crystal structure of which has been solved and revealed the general fold for this class of enzymes and the interactions of the non-covalently bound coenzyme ThDP with...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540500167203
更新日期:2005-07-01 00:00:00
abstract::Cocaine is a powerful central nervous stimulant and among the most abused of drugs. Despite decades of efforts, however, no effective pharmacological treatments are available against cocaine addiction or toxic effects. Classical receptor-antagonist therapeutic approaches have not yielded significant effects, although ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/1521654031000138541
更新日期:2003-07-01 00:00:00
abstract::Stem cells from human exfoliated deciduous teeth (SHEDs) are highly proliferative, clonogenic, and multipotent stem cells with a neural crest cell origin. This property could be a desirable option for potential therapeutic applications. In this study, we focus on the effects of Rho kinase inhibitors Y-27632 and Noggin...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2208
更新日期:2020-04-01 00:00:00
abstract::In Streptomyces fradiae, calcium ions induce alterations in intensity and specificity of the secondary metabolism and stimulate sporulation. Using in vivo labeling, we demonstrate that in S. fradiae phosphorylation of some proteins are also influenced by Ca2+ added exogenously. Calcium ions at physiological concentrat...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803699
更新日期:2000-08-01 00:00:00
abstract::This study examined whether cell cycle regulatory proteins, such as cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors, regulate type II collagen expression and mediate interlukin-1 (IL-1beta)-induced suppression of type II collagen expression in articular chondrocytes. IL-1beta inhibited type II collagen ex...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540701245022
更新日期:2007-02-01 00:00:00
abstract::N-Acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a critical negative regulator of fibrosis development in the liver. However, its extremely short half-life in vivo greatly compromises its potential applications. Here, we report an Ac-SDKP analog peptide with d-amino acid replacement (Ac-SDD KD P). The stability of A...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2037
更新日期:2019-09-01 00:00:00
abstract::During the hand plate development, the processes of cell differentiation and control of cell death are relevant to ensure a correct shape of the limb. The progenitor cell pool that later will differentiate into cartilage to form the digits arises from undifferentiated mesenchymal cells beneath the apical ectodermal ri...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.563
更新日期:2011-10-01 00:00:00
abstract::Retinitis pigmentosa comprises a large and exceptionally heterogeneous group of hereditary disorders of the retina. As a result of an extensive investigation around the world, primary genetic lesions have been described in many genes. Some of these genes encode enzymes that are involved in the signal transduction path...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540050167007
更新日期:2000-06-01 00:00:00
abstract::The 10th jubilee conference (IPK2019) took place on September 15-19, 2019 in Warsaw, on the Ochota campus as the IUBMB Focused Meeting entitled "Inhibitors of Protein Kinases. Kinase inhibitors in target biology and disease". ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2303
更新日期:2020-06-01 00:00:00
abstract::Pancreatic islet beta-cells are poised to generate metabolic messengers in the mitochondria that link glucose metabolism to insulin exocytosis. This is accomplished through the tight coupling of glycolysis to mitochondrial activation. The messenger molecules ATP and glutamate are produced after the metabolism of glyco...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/152165400410236
更新日期:2000-05-01 00:00:00
abstract::The invasion and chemoresistance are crucial causes of morbidity and relapse for cancer patients. Axl is implicated in the modulation of cell invasion, cancer metastasis, and chemosensitivity in human breast carcinoma cell lines. Both breast cancer cell lines and tissues displayed increased expression of Axl, and it o...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1285
更新日期:2014-07-01 00:00:00
abstract::Shiga toxin (Stx) producing Escherichia coli (STEC) is responsible to bloody diarrhea (hemorrhagic colitis) and the hemolytic uremic syndrome (HUS). STEC strains carry inducible lambda phages integrated into their genomes that encode Stx 1 and/or 2, with several allelic variants each one. O157:H7 is the serotype that ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1206
更新日期:2013-10-01 00:00:00
abstract::Studies have shown that despite the decreasing mortality rates of kidney cancer patients, its incidence is increasing. Therefore, a comprehensive re-evaluation of treatment options is necessary to provide appropriate treatments for the increasing number of patients. Moreover, the side effects caused by surgery, which ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2384
更新日期:2020-11-01 00:00:00
abstract::Silymarin, which is derived from the seeds of Silybum marianum, has been widely used to prevent and treat liver diseases. In our previous study, we reported that at concentrations above the minimal inhibitory concentration (MIC), silymarin exhibited antifungal activity against Candida albicans by targeting its plasma ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1716
更新日期:2018-03-01 00:00:00
abstract::Renal ischemia/reperfusion (I/R) is an alternation of renal hemodynamics, which results in diverse postischemic responses and eventually acute kidney injury. Although renal ischemic preconditioning (IPC) is known to protect the kidney from I/R injury, the precise renoprotective mechanisms are not completely understood...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1972
更新日期:2019-03-01 00:00:00
abstract::Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to this process. Its activity is modulated in a coordinated manner via a ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.411
更新日期:2011-01-01 00:00:00
abstract::Role of nitric oxide (NO) on the expression of organic anion transporter 2 (OAT2) located in sinusoidal domain of hepatocytes has been investigated. Effect of NO generated in vivo in rat and delivered in vitro to hepatocytes was determined. Lipopolysaccharide (LPS) and spermine NONOate (SPER/NO) were selected as the N...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540214534
更新日期:2002-09-01 00:00:00
abstract::Hepatocyte mitochondrial aquaporin-8 (mtAQP8) works as a multifunctional membrane channel protein that facilitates the uptake of ammonia for its detoxification to urea as well as the mitochondrial release of hydrogen peroxide. Since early oligonucleotide microarray studies in liver of cholesterol-fed mice showed an AQ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1615
更新日期:2017-05-01 00:00:00
abstract::Nucleotides of transfer RNAs (tRNAs) are highly modified, particularly at the anticodon. Bacterial tRNAs that read A-ending codons are especially notable. The U34 nucleotide canonically present in these tRNAs is modified by a wide range of complex chemical constituents. An additional two A-ending codons are not read b...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2120
更新日期:2019-08-01 00:00:00