An immune infiltration signature to predict the overall survival of patients with colon cancer.

abstract：:Nur77 is a member of nuclear receptor superfamily that acts as a transcription factor and regulates expression of multiple genes. Subcellular localization of Nur77 protein plays an important role in the survival and cell death. In this study, we have predicted and confirmed alternatively spliced two new transcripts of...

journal_title：IUBMB life

authors： Rehman SU,Sarwar T,Husain MA,Ishqi HM,Tabish M

更新日期：2017-02-01 00:00:00

abstract：:Availability of the human genome data has enabled the exploration of a huge amount of biological information encoded in it. There are extensive ongoing experimental efforts to understand the biological functions of the gene products encoded in the human genome. However, computational analysis can aid immensely in the ...

journal_title：IUBMB life

authors： Pandit SB,Balaji S,Srinivasan N

更新日期：2004-06-01 00:00:00

abstract：:Prostate cancer (PCa) is considered the most common malignancy in men. The aim of this study is to assess the role of serum miR-15a and miR-16-1 expression in PCa development, diagnosis and prognosis aiming to find a specific noninvasive biomarker. This study comprised 70 patients with PCa, 70 patients complaining of ...

journal_title：IUBMB life

authors： Zidan HE,Abdul-Maksoud RS,Elsayed WSH,Desoky EAM

更新日期：2018-05-01 00:00:00

abstract：:Recent structural studies of proteins mediating membrane fusion reveal intriguing similarities between diverse viral and mammalian systems. Particularly striking is the close similarity between the transmembrane envelope glycoproteins from the retrovirus HTLV-1 and the filovirus Ebola. These similarities suggest simil...

journal_title：IUBMB life

authors： Poumbourios P,Center RJ,Wilson KA,Kemp BE,Kobe B

更新日期：1999-08-01 00:00:00

abstract：:The sodA gene coding for manganese superoxide dismutase (Mn-SOD) from the marine microorganism Vibrio parahaemolyticus was cloned, sequenced, and overexpressed in Escherichia coli by use of the pET20b (+) expression vector. The full-length gene consisted of a 588-bp open reading frame and encoded a polypeptide of 196 ...

journal_title：IUBMB life

authors： Shyu YC,Lin FP

更新日期：1999-09-01 00:00:00

abstract：:Copper has a wide and important role in biological systems, determining conformation and activity of many metalloproteins and enzymes, such as cytochrome oxidase and superoxide dismutase . Furthermore, due to its possible reactivity with nonspecific proteins and toxic effects, elaborate systems of absorption, concentr...

journal_title：IUBMB life

authors： Inesi G

更新日期：2017-04-01 00:00:00

abstract：:Specific RNAs can function as sinks for endogenous miRNAs, known as competing endogenous RNAs (ceRNAs). Here, we confirm a miR-124 mediated ceRNA crosstalk between LAMC1 and CD151 in hepatocellular carcinoma (HCC). miR-124 negatively regulates LAMC1 expression through two miRNA binding sites within its 3' untranslated...

journal_title：IUBMB life

authors： Yang ZP,Ma HS,Wang SS,Wang L,Liu T

更新日期：2017-08-01 00:00:00

abstract：:In this study, two different epitope tags (HA, c-myc) were introduced near the N terminus of the yeast PMA1 H(+)-ATPase. The resulting proteins were indistinguishable from the wild-type ATPase in their ability to travel through the secretory pathway, as judged by quantitative immunoblotting of isolated secretory vesic...

journal_title：IUBMB life

authors： dos Santos CF,DeWitt ND,Gupta SS,Allen KE,Slayman CW

更新日期：2000-02-01 00:00:00

abstract：:Altered activity of the proteolytic machine-the 26S proteasome is observed in many disease conditions. Hence, either inhibition or activation of the 26S proteasome is thought to be a novel therapy for treatment of certain diseases such as cancer and neurodegenerative disorders. In this study, we tested the potential o...

journal_title：IUBMB life

authors： Gopalakrishnan S,Ediga HH,Reddy SS,Reddy GB,Ismail A

更新日期：2018-05-01 00:00:00

abstract：:The activation and incorporation of selenium into selenocysteine containing selenoproteins has been well established in an Escherichia coli model system but there is little specific information concerning the transport and intracellular trafficking of selenium in biological systems in general. A selenium transport rol...

journal_title：IUBMB life

authors： Self WT,Pierce R,Stadtman TC

更新日期：2004-08-01 00:00:00

abstract：:The pathways for ligand entry and exit in myoglobin have now been well established by a wide variety of experimental results, including pico- to nano- to microsecond transient absorbance measurements and time-resolved X-ray crystallographic measurements. Trp insertions have been used to block, one at a time, the three...

journal_title：IUBMB life

authors： Olson JS,Soman J,Phillips GN Jr

更新日期：2007-08-01 00:00:00

abstract：:The beta/alpha-barrel motif was once considered to be a single protein domain. In recent years, however, it has been shown to consist of smaller substructures displaying the ability to fold autonomously. Here we review the current status of experimental findings concerning the motif's folding behavior in the light of ...

journal_title：IUBMB life

authors： Maiti S,Luthra-Guptasarma M,Guptasarma P

更新日期：2002-10-01 00:00:00

abstract：:Hydrogen peroxide is a major regulator of plant programmed cell death (PCD) but little is known about the downstream genes from the H(2)O(2)-signaling network that mediate the cell death. To address this question, a novel system for studying H(2)O(2)-induced programmed cell death in Arabidopsis thaliana was used. The ...

journal_title：IUBMB life

authors： Gechev TS,Minkov IN,Hille J

更新日期：2005-03-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a common malignant cancer with unfavorable prognosis, and the epithelial-to-mesenchymal transition (EMT) is a critical contributor to OSCC metastasis. Recently, we have shown that sirtuin 7 (Sirt7) is associated with EMT and OSCC metastasis by acetylating small mother against dec...

journal_title：IUBMB life

authors： Jia B,Zhang S,Wu S,Zhu Q,Li W

更新日期：2020-12-16 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play important roles in the initiation and progression of various cancers, including laryngeal squamous cell carcinoma (LSCC). Recently, lncRNA Sox2 overlapping transcript (SOX2-OT) has been identified as an oncogene in various cancers. However, the functional role and the regulatory mech...

journal_title：IUBMB life

authors： Tai Y,Ji Y,Liu F,Zang Y,Xu D,Ma S,Qin L,Ma J

更新日期：2019-09-01 00:00:00

abstract：:Iron presents us with a paradox. Without it, cells simply cannot survive because iron is an essential cofactor for many enzymes in critical biochemical pathways. However, when iron is present in excess, it can be highly cytotoxic due to its propensity to catalyze the formation of reactive oxygen radicals. To cater for...

journal_title：IUBMB life

authors： Anderson GJ

更新日期：2001-01-01 00:00:00

abstract：:The multifaceted relationship between mitochondria and the rest of the cell is reviewed in the context of myocardial ischemia. Paradoxically, mitochondria can exacerbate the ischemic damage, especially at the onset of reperfusion. Indeed, the recovery of oxidative phosphorylation in the presence of an excessive energy...

journal_title：IUBMB life

authors： Di Lisa F

更新日期：2001-09-01 00:00:00

abstract：:In the Antarctic, fishes of dominant suborder Notothenioidei have evolved in a unique thermal scenario. Phylogenetically related taxa of the suborder live in a wide range of latitudes, in Antarctic, sub-Antarctic and temperate oceans. Consequently, they offer a remarkable opportunity to study the physiological and bio...

journal_title：IUBMB life

authors： Verde C,Giordano D,di Prisco G

更新日期：2008-01-01 00:00:00

abstract：:Triclosan, a well-known inhibitor of Enoyl Acyl Carrier Protein Reductase (ENR) from several pathogenic organisms, is a promising lead compound to design effective drugs. We have solved the X-ray crystal structures of Plasmodium falciparum ENR in complex with triclosan variants having different substituted and unsubst...

journal_title：IUBMB life

authors： Maity K,Bhargav SP,Sankaran B,Surolia N,Surolia A,Suguna K

更新日期：2010-06-01 00:00:00

abstract：:Members of the GATA family of transcription factors play key roles in the differentiation of specific cell lineages by regulating the expression of target genes. Three GATA factors play distinct roles in hematopoietic differentiation. In order to better understand how these GATA factors function to regulate genes thro...

journal_title：IUBMB life

authors： Hardison RC,Zhang Y,Keller CA,Xiang G,Heuston EF,An L,Lichtenberg J,Giardine BM,Bodine D,Mahony S,Li Q,Yue F,Weiss MJ,Blobel GA,Taylor J,Hughes J,Higgs DR,Göttgens B

更新日期：2020-01-01 00:00:00

abstract：:Transketolase (TK, EC 2.2.1.1), the key enzyme of the non-oxidative branch of pentose phosphate pathway of hydrocarbon transformation, plays an important role in a system of substrate rearrangement between pentose shunt and glycolysis, acting as a reversible link between the two metabolic pathways. In addition, it sup...

journal_title：IUBMB life

authors： Kochetov GA,Sevostyanova IA

更新日期：2010-11-01 00:00:00

abstract：:The reaction between nitric oxide ((.)NO) and oxygen yields reactive species capable of oxidizing and nitrosating proteins, as well as deaminating DNA bases. Although this reaction is considered too slow to be biologically relevant, it has been shown that membranes, lipoproteins, mitochondria and possibly proteins can...

journal_title：IUBMB life

authors： Möller MN,Li Q,Lancaster JR Jr,Denicola A

更新日期：2007-04-01 00:00:00

abstract：:The cancer microenvironment and the interactions between cancer and surrounding tissue cells are thought to play a pivotal role in tumor development and progression. Glycosaminoglycans (GAGs)/proteoglycans (PGs) are major constituents of the extracellular matrix, the composition of which may affect various cellular fu...

journal_title：IUBMB life

authors： Chatzinikolaou G,Nikitovic D,Asimakopoulou A,Tsatsakis A,Karamanos NK,Tzanakakis GN

更新日期：2008-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an enveloped positive-strand RNA virus of the Flaviviridae family. It has a genome of about 9,600 nucleotides encoding a large polyprotein (about 3,000 amino acids) that is processed by cellular and viral proteases into at least 10 structural and nonstructural viral proteins. A novel HCV pro...

journal_title：IUBMB life

authors： Vassilaki N,Mavromara P

更新日期：2009-07-01 00:00:00

abstract：:The conformational stability of the homotetrameric Plasmodium falciparum beta-ketoacyl-ACP reductase (FabG) was determined by guanidinium chloride-induced isothermal and thermal denaturation. The reversible unfolding transitions were monitored by intrinsic fluorescence, circular dichroism (CD) spectroscopy and by meas...

journal_title：IUBMB life

authors： Karmodiya K,Sajad S,Sinha S,Maity K,Suguna K,Surolia N

更新日期：2007-07-01 00:00:00

abstract：:It is known that that human serum albumin (HSA) and alpha-lactalbumin (LA) possess DNA-binding sites. Electrophoretically homogeneous HSA and LA containing no canonical enzymes were isolated from human sera and milk. Here we have analyzed for the first time the possibility of DNA hydrolysis by these proteins. It was s...

journal_title：IUBMB life

authors： Soboleva SE,Guschina TA,Nevinsky GA

更新日期：2018-06-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a lethal malignancy and its prognosis remains dismal. Thus, a deeper understanding of the mechanisms is needed to provide a new insight for new therapies. It has been reported that long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) was downregulated in OSCC tissues, h...

journal_title：IUBMB life

authors： Tan J,Xiang L,Xu G

更新日期：2019-07-01 00:00:00

abstract：:The pathophysiology of some inflammatory arterial diseases (such as vasculitis, atherogenesis and aneurysms) has been widely investigated in the last decades. Among different soluble molecules, proinflammatory cytokines (such as TNF-α, IL-1 and IL-6) were shown to trigger critical pathways regulating these arterial di...

journal_title：IUBMB life

authors： Carbone F,Montecucco F

更新日期：2015-01-01 00:00:00

abstract：:Cartilage engineering is one challenging issue in regenerative medicine. Low oxygen tension or hypoxia inducible factor-1 (HIF-1α) gene therapy are promising strategies in the field of cartilage repair. Previously, we showed that hypoxia and its mediator HIF-1 regulate matrix genes expression (collagens and aggrecan)....

journal_title：IUBMB life

authors： Duval E,Bouyoucef M,Leclercq S,Baugé C,Boumédiene K

更新日期：2016-09-01 00:00:00

abstract：:The human nuclear estrogen receptors (i.e., ERalpha and ERbeta), as other transcriptional factors, regulate cellular processes inducing genomic events. In addition, the binding of 17beta-estradiol to ERs induces different membrane initiating non-genomic signaling. The non-genomic effects of ER are independent of trans...

journal_title：IUBMB life

authors： Acconcia F,Bocedi A,Ascenzi P,Marino M

更新日期：2003-01-01 00:00:00