Abstract:
:The beta/alpha-barrel motif was once considered to be a single protein domain. In recent years, however, it has been shown to consist of smaller substructures displaying the ability to fold autonomously. Here we review the current status of experimental findings concerning the motif's folding behavior in the light of what is currently known about (a) the relative rates of formation of helices and sheets in proteins, in general, and (b) the peculiarities of topology and architecture of the motif, in particular, to develop a detailed phenomenological understanding of how beta/alpha-barrels might form through the modular folding and assembly of substructures.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Maiti S,Luthra-Guptasarma M,Guptasarma Pdoi
10.1080/15216540214924keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
213-21issue
4eissn
1521-6543issn
1521-6551journal_volume
54pub_type
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