Loss of TP53I11 Enhances the Extracellular Matrix-independent Survival by Promoting Activation of AMPK.

abstract：:Prostate specific antigen (PSA) is a serine protease that is exclusively produced in the prostate, and its detection is the only laboratory test available for screening men for prostate cancer (PC). The interpretation of the assay is difficult since it is specific for prostate tissue and cellular growth, but not for P...

journal_title：IUBMB life

authors： Mener DJ

更新日期：2010-08-01 00:00:00

abstract：:In this study, two different epitope tags (HA, c-myc) were introduced near the N terminus of the yeast PMA1 H(+)-ATPase. The resulting proteins were indistinguishable from the wild-type ATPase in their ability to travel through the secretory pathway, as judged by quantitative immunoblotting of isolated secretory vesic...

journal_title：IUBMB life

authors： dos Santos CF,DeWitt ND,Gupta SS,Allen KE,Slayman CW

更新日期：2000-02-01 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase Akt/mammalian target of rapamycin (mTOR), Ras/Raf/extracellular signal-regulated kinase (ERK), and phosph...

journal_title：IUBMB life

authors： Troncoso R,Díaz-Elizondo J,Espinoza SP,Navarro-Marquez MF,Oyarzún AP,Riquelme JA,Garcia-Carvajal I,Díaz-Araya G,García L,Hill JA,Lavandero S

更新日期：2013-07-01 00:00:00

abstract：:Transfected human apoptosis signal-regulating kinase 1 (ASK1) produces a 150 kDa protein. However, we have detected endogenous ASK1 predominantly as 39 and 50 kDa C-terminal and 75 and 110 kDa N-terminal fragments in a panel of nontransfected cancer cell lines and HUVEC endothelial cells. This suggests that in nonapop...

journal_title：IUBMB life

authors： Stordal B,Davey R

更新日期：2008-03-01 00:00:00

abstract：:Mutations in the breast cancer susceptibility gene BRCA1 predispose individuals to breast and ovarian cancers. Cofactor of BRCA1 (COBRA1), a novel protein, was isolated as a BRCA1-interacting protein. However, the role of COBRA1 in breast cancer is poorly understood. In this study, we demonstrate that COBRA1 mRNA was ...

journal_title：IUBMB life

authors： Zhu J,Song S,Jiang Z,Yan J,Lu Q,Huang C,Ye Q

更新日期：2004-03-01 00:00:00

abstract：:The amino acids glutamate and gamma-aminobutyric acid (GABA) have primarily been characterized as the most prevalent excitatory and inhibitory, respectively, neurotransmitters in the vertebrate central nervous system. However, the role of these signaling molecules extends far beyond the synapse. GABA, glutamate, and t...

journal_title：IUBMB life

authors： Dave KA,Bordey A

更新日期：2009-05-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with impairments in social communication, restricted, repetitive and stereotyped behaviors. Both genetic and environmental factors are known to contribute toward pathophysiology of Autism. Environmental influences on gene expression can be mediate...

journal_title：IUBMB life

authors： Alex AM,Saradalekshmi KR,Shilen N,Suresh PA,Banerjee M

更新日期：2019-07-01 00:00:00

abstract：:Altered activity of the proteolytic machine-the 26S proteasome is observed in many disease conditions. Hence, either inhibition or activation of the 26S proteasome is thought to be a novel therapy for treatment of certain diseases such as cancer and neurodegenerative disorders. In this study, we tested the potential o...

journal_title：IUBMB life

authors： Gopalakrishnan S,Ediga HH,Reddy SS,Reddy GB,Ismail A

更新日期：2018-05-01 00:00:00

abstract：:The complex life cycle of intracellular parasitic protozoans entails multiple rounds of DNA replication and mitosis followed by cytokinesis to release daughter parasites. To gain insights into mitotic events it is imperative to identify the biomarkers that constitute the chromosome segregation machinery in the parasit...

journal_title：IUBMB life

authors： Verma G,Surolia N

更新日期：2018-08-01 00:00:00

abstract：:Myosin light chain kinase (MLCK) is a regulatory protein for smooth muscle contraction, which acts by phosphorylating 20-kDa myosin light chain (MLC20) to activate the myosin ATPase activity. Although this mode of action is well-established, there are numerous reports of smooth muscle contraction that is not associate...

journal_title：IUBMB life

authors： Gao Y,Ye LH,Kishi H,Okagaki T,Samizo K,Nakamura A,Kohama K

更新日期：2001-06-01 00:00:00

abstract：:Transketolase (TK, EC 2.2.1.1), the key enzyme of the non-oxidative branch of pentose phosphate pathway of hydrocarbon transformation, plays an important role in a system of substrate rearrangement between pentose shunt and glycolysis, acting as a reversible link between the two metabolic pathways. In addition, it sup...

journal_title：IUBMB life

authors： Kochetov GA,Sevostyanova IA

更新日期：2010-11-01 00:00:00

abstract：:Cisplatin (CP), as a chemotherapeutic drug, causes nephrotoxicity that has limited the clinical utility of CP. Gliclazide (GLZ), as an antihyperglycemic drug, at low dose has antioxidant property. In this study, we aimed to investigate the protective effect of GLZ against CP-induced acute renal injury. Sixty-four BALB...

journal_title：IUBMB life

authors： Taghizadeh F,Hosseinimehr SJ,Zargari M,Karimpour Malekshah A,Talebpour Amiri FB

更新日期：2020-09-01 00:00:00

abstract：:Interplay between the apoptosis, DNA damage, and oxidative stress as a host response to dengue viral infections remains unclear. Peripheral blood mononuclear cells (PBMCs) were isolated from 60 dengue infected patients, 20 patients with febrile illness other than dengue (OFI) and 10 non-febrile illness (NFI) patients....

journal_title：IUBMB life

authors： Cherupanakkal C,Samadanam DM,Muthuraman KR,Ramesh S,Venkatesan A,Balakrishna Pillai AK,Rajendiran S

更新日期：2018-11-01 00:00:00

abstract：:Although the amino acid sequences and the structures of pyruvate kinase (PYK) isozymes are highly conserved, allosteric regulations differ. This suggests that amino acids with low conservation play important roles in the allosteric mechanism. The current work exploits a 'natural screen'- the 122 point mutations identi...

journal_title：IUBMB life

authors： Pendergrass DC,Williams R,Blair JB,Fenton AW

更新日期：2006-01-01 00:00:00

abstract：:The multifaceted relationship between mitochondria and the rest of the cell is reviewed in the context of myocardial ischemia. Paradoxically, mitochondria can exacerbate the ischemic damage, especially at the onset of reperfusion. Indeed, the recovery of oxidative phosphorylation in the presence of an excessive energy...

journal_title：IUBMB life

authors： Di Lisa F

更新日期：2001-09-01 00:00:00

abstract：:Carbon monoxide (CO) is a gaseous transmitter that is known to be involved in several physiological processes, but surprisingly it is also becoming a promising molecule to treat several pathologies including stroke and cancer. CO can cross the plasma membrane and activate guanylate cyclase, increasing the cGMP concent...

journal_title：IUBMB life

authors： Retamal MA,León-Paravic CG,Ezquer M,Ezquer F,Del Rio R,Pupo A,Martínez AD,González C

更新日期：2015-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common malignancies with poor prognosis. Oxaliplatin-based chemotherapy is an important treatment for CRC; however, the cells develop resistance to therapy. The mechanisms underlying oxaliplatin resistance are complex and unclear. There is increasing evidence that microRNAs (...

journal_title：IUBMB life

authors： Moradi Marjaneh R,Khazaei M,Ferns GA,Avan A,Aghaee-Bakhtiari SH

更新日期：2019-10-01 00:00:00

abstract：:Tumstatin is a candidate tumor suppressor that plays an important role in tumor growth and angiogenesis. The purpose of this study was to evaluate the correlation between tumstatin-mRNA expression and the clinicopathologic characteristics, tumor angiogenesis, outcome of patients with non-small cell lung cancer (NSCLC)...

journal_title：IUBMB life

authors： Luo YQ,Ming Z,Zhao L,Yao LJ,Dong H,Du JP,Wu SZ,Hu W

更新日期：2012-05-01 00:00:00

abstract：:Red blood cells of yellow-spotted river turtles (Podocnemis unifilis, Pleurodira, Chelonia, REPTILIA) have two hemoglobin (Hb) components, Hb A and Hb D. We purified the hemoglobin component homologous to amniote (reptiles, birds, and mammals) adult Hb A which comprises two identical α(A) -globin polypeptides and two ...

journal_title：IUBMB life

authors： Hasegawa T,Shishikura F,Kuwada T

更新日期：2011-03-01 00:00:00

abstract：:Renal ischemia/reperfusion (I/R) is an alternation of renal hemodynamics, which results in diverse postischemic responses and eventually acute kidney injury. Although renal ischemic preconditioning (IPC) is known to protect the kidney from I/R injury, the precise renoprotective mechanisms are not completely understood...

journal_title：IUBMB life

authors： Li JR,Ou YC,Wu CC,Wang JD,Lin SY,Wang YY,Chen WY,Chen CJ

更新日期：2019-03-01 00:00:00

abstract：:Human ecto-ATPase (ecto-nucleoside triphosphate diphosphohydrolase 2 [eNTPDase2], also known as CD39L1) has been expressed and characterized in COS cells. It exhibits some unusual enzymology that is similar to a few members of this class of proteins but different from the majority of the family members. Hydrolysis of ...

journal_title：IUBMB life

authors： Hicks-Berger CA,Kirley TL

更新日期：2000-07-01 00:00:00

abstract：:Apolipoprotein E (apoE) is a major constituent of lipoproteins mediating peripheral uptake of lipids including the lipid-soluble vitamin alpha-tocopherol (alpha-toc). In a recent study, we observed significant lower alpha-toc concentrations in the lung of apoE4 compared with apoE3 transgenic mice. In this study, we de...

journal_title：IUBMB life

authors： Huebbe P,Jofre-Monseny L,Rimbach G

更新日期：2009-04-01 00:00:00

abstract：:Sirolimus(SRL, Rapamune(â), rapamycin) is a highly specific inhibitor of mammalian target of rapamycin (mTOR). Sirolimus exerts its biological activity by inhibiting the serine-threonine kinase mammalian target of rapamycin (mTOR), which regulates important cellular processes such as control of cell cycle, cell size, ...

journal_title：IUBMB life

authors： Wang Y,Zhao Q,Ma S,Yang F,Gong Y,Ke C

更新日期：2007-11-01 00:00:00

abstract：:Over the years, microRNA-20b-3p (miR-20b-3p) has been found to play an essential role in human diseases; we aimed to investigate the effect of miR-20b-3p on the progression of diabetic retinopathy (DR). The DR rat models were established by streptozotocin injection and treated with miR-20b-3p mimics, silenced, or over...

journal_title：IUBMB life

authors： Wang S,Du S,Lv Y,Wang W,Zhang F

更新日期：2020-07-01 00:00:00

abstract：:Recently the crystal structure of creatine kinase from Torpedocalifornica was determined to 2.1 A. The dimeric structure revealed two different forms in the unit cell: one monomer was bound to a substrate, MgADP, and the other monomer was bound to a transition-state analogue complex composed of MgADP, nitrate and crea...

journal_title：IUBMB life

authors： Wang PF,Flynn AJ,McLeish MJ,Kenyon GL

更新日期：2005-04-01 00:00:00

abstract：:Shiga toxin (Stx) producing Escherichia coli (STEC) is responsible to bloody diarrhea (hemorrhagic colitis) and the hemolytic uremic syndrome (HUS). STEC strains carry inducible lambda phages integrated into their genomes that encode Stx 1 and/or 2, with several allelic variants each one. O157:H7 is the serotype that ...

journal_title：IUBMB life

authors： Ibarra C,Amaral MM,Palermo MS

更新日期：2013-10-01 00:00:00

abstract：:Exosomes are nano-sized extracellular vesicles containing a cell-specific biologically active cargo of proteins and genetic materials. Exosomes are constitutively released from almost all cell-types and affect neighboring or distant cells through a complex intercellular exchange of the genetic information and/or regul...

journal_title：IUBMB life

authors： Zhou R,Wang L,Zhao G,Chen D,Song X,Momtazi-Borojeni AA,Yuan H

更新日期：2020-12-01 00:00:00

abstract：:We propose a new hypothesis for the molecular mechanism by which neuroglobin exerts its protective effect in hypoxia-induced cell death. Our recent observation of a very rapid electron-transfer reaction between ferrous neuroglobin and ferric cytochrome c is central to this hypothesis. In contrast to previously suggest...

journal_title：IUBMB life

authors： Fago A,Mathews AJ,Brittain T

更新日期：2008-06-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) regulates remodeling of the left ventricle after myocardial infarction (MI) and is tightly linked to the inflammatory response. The inflammatory response serves to recruit leukocytes as part of the wound healing reaction to the MI injury, and infiltrated leukocytes produce cytokines ...

journal_title：IUBMB life

authors： Deleon-Pennell KY,Altara R,Yabluchanskiy A,Modesti A,Lindsey ML

更新日期：2015-08-01 00:00:00

abstract：:The purpose of this study was to confirm protein-protein interaction between cyclooxygenase-1 (COX-1) and caveolins. The interaction of cyclooxygenase-1 and caveolins in the cultured human embryonic kidney (HEK 293) cells was investigated using immuno-precipitation and Western blot analysis. In HEK 293 cells, high lev...

journal_title：IUBMB life

authors： Cha SH,Jung NH,Kim BR,Kim HW,Kwak JO

更新日期：2004-04-01 00:00:00