Carbon monoxide: A new player in the redox regulation of connexin hemichannels.

abstract：:In many organisms the processes of DNA replication and recombination are closely linked. For instance, in bacterial and eukaryotic systems, replication forks can become stalled or damaged, in many cases leading to the formation of double stranded breaks. Replication restart is an essential mechanism in which the recom...

journal_title：IUBMB life

authors： Wilkinson DE,Weller SK

更新日期：2003-08-01 00:00:00

abstract：:Depurinating DNA adducts formed by aromatic hydrocarbons and catechol estrogen quinones play a major role in cancer initiation. Most of these adducts depurinate instantaneously, but some guanine adducts depurinate from DNA with half-lives of hours. We report here, that after 10 h at 37 °C, reaction of estradiol-3,4-qu...

journal_title：IUBMB life

authors： Cavalieri E,Saeed M,Zahid M,Cassada D,Snow D,Miljkovic M,Rogan E

更新日期：2012-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating neurodegenerative disorder that results in loss of memory and cognitive function, eventually leading to dementia. A key neuropathological event in AD is the cerebral accumulation of senile plaques formed by aggregates of amyloid-β-peptides (Aβ). Aβ results from two sequential ...

journal_title：IUBMB life

authors： Tamagno E,Guglielmotto M,Monteleone D,Vercelli A,Tabaton M

更新日期：2012-12-01 00:00:00

abstract：:The conformational stability of the homotetrameric Plasmodium falciparum beta-ketoacyl-ACP reductase (FabG) was determined by guanidinium chloride-induced isothermal and thermal denaturation. The reversible unfolding transitions were monitored by intrinsic fluorescence, circular dichroism (CD) spectroscopy and by meas...

journal_title：IUBMB life

authors： Karmodiya K,Sajad S,Sinha S,Maity K,Suguna K,Surolia N

更新日期：2007-07-01 00:00:00

abstract：:Exosomes are nano-sized extracellular vesicles containing a cell-specific biologically active cargo of proteins and genetic materials. Exosomes are constitutively released from almost all cell-types and affect neighboring or distant cells through a complex intercellular exchange of the genetic information and/or regul...

journal_title：IUBMB life

authors： Zhou R,Wang L,Zhao G,Chen D,Song X,Momtazi-Borojeni AA,Yuan H

更新日期：2020-12-01 00:00:00

abstract：:In vivo site-directed mutagenesis by single-stranded deoxyribonucleic acid recombineering is a facile method to change the color of fluorescent proteins (FPs) without cloning. Two different starting alleles of GFP were targeted for mutagenesis: gfpmut3* residing in the Escherichia coli genome and egfp carried by a bac...

journal_title：IUBMB life

authors： Valledor M,Hu Q,Schiller P,Myers RS

更新日期：2012-08-01 00:00:00

abstract：:Pancreatic islet beta-cells are poised to generate metabolic messengers in the mitochondria that link glucose metabolism to insulin exocytosis. This is accomplished through the tight coupling of glycolysis to mitochondrial activation. The messenger molecules ATP and glutamate are produced after the metabolism of glyco...

journal_title：IUBMB life

authors： Ishihara H,Wollheim CB

更新日期：2000-05-01 00:00:00

abstract：:Cancers have a clonal origin, yet their chromosomes and genes are non-clonal or heterogeneous due to an inherent genomic instability. However, the cause of this genomic instability is still debated. One theory postulates that mutations in genes that are involved in DNA repair and in chromosome segregation are the prim...

journal_title：IUBMB life

authors： Duesberg P,Fabarius A,Hehlmann R

更新日期：2004-02-01 00:00:00

abstract：:The immunosuppressant cyclosporin A (CsA)-sensitive nuclear factor of activated T cells 1 (NFAT1) has been known to be a transcriptional regulator of cytokine and viral genes during the immune response. By analyses of serial deletion, mutation, and heterologous promoter assay, we report here that the CsA-sensitive NFA...

journal_title：IUBMB life

authors： Lee JH,Rho HM

更新日期：2001-04-01 00:00:00

abstract：:Studies have shown that despite the decreasing mortality rates of kidney cancer patients, its incidence is increasing. Therefore, a comprehensive re-evaluation of treatment options is necessary to provide appropriate treatments for the increasing number of patients. Moreover, the side effects caused by surgery, which ...

journal_title：IUBMB life

authors： Maleki Dana P,Reiter RJ,Hallajzadeh J,Asemi Z,Mansournia MA,Yousefi B

更新日期：2020-11-01 00:00:00

abstract：:Interplay between the apoptosis, DNA damage, and oxidative stress as a host response to dengue viral infections remains unclear. Peripheral blood mononuclear cells (PBMCs) were isolated from 60 dengue infected patients, 20 patients with febrile illness other than dengue (OFI) and 10 non-febrile illness (NFI) patients....

journal_title：IUBMB life

authors： Cherupanakkal C,Samadanam DM,Muthuraman KR,Ramesh S,Venkatesan A,Balakrishna Pillai AK,Rajendiran S

更新日期：2018-11-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common malignancies with poor prognosis. Oxaliplatin-based chemotherapy is an important treatment for CRC; however, the cells develop resistance to therapy. The mechanisms underlying oxaliplatin resistance are complex and unclear. There is increasing evidence that microRNAs (...

journal_title：IUBMB life

authors： Moradi Marjaneh R,Khazaei M,Ferns GA,Avan A,Aghaee-Bakhtiari SH

更新日期：2019-10-01 00:00:00

abstract：:Selenium is an essential component of several enzymes and proteins in a number of methane-producing archae. Information concerning accessory proteins that function in selenium transport processes, however, is limited. A novel selenium-binding protein with a potential transport role and a selenocysteine lyase that serv...

journal_title：IUBMB life

authors： Stadtman T

更新日期：2004-07-01 00:00:00

abstract：:Tilorone hydrochloride, a low-molecular-weight synthetic compound, induces interferon production and has been reported to have both antiviral and antitumor activities. Here, we have demonstrated the ability of tilorone to activate NK cells and specific subpopulations of cytotoxic CD4+ and CD8+ T lymphocytes that recog...

journal_title：IUBMB life

authors： Sharapova TN,Romanova EA,Sashchenko LP,Yashin DV

更新日期：2019-03-01 00:00:00

abstract：:The direct relationship between obesity and breast cancer has been elucidated recently with the identification of a cholesterol derivative 27-hydroxycholesterol (27HC), an endogenous SERM that can act through estrogen receptor (ER)-mediated mechanisms. Our recent research shed light on the possible SERM-like property ...

journal_title：IUBMB life

authors： Vini R,Juberiya AM,Sreeja S

更新日期：2016-02-01 00:00:00

abstract：:The functional effect of the interaction of E2F1 and hepatitis B virus X protein (HBx) on the promoter of human p53 gene was studied using chloramphenicol acetyl transferase (CAT) assay. E2F1 activated the p53 promoter through E2F1 binding site. As previously reported, HBx repressed the p53 promoter through E-box. Whe...

journal_title：IUBMB life

authors： Choi M,Lee H,Rho HM

更新日期：2002-06-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 [1,25(OH)2 D3 ] has recently been shown to have immunomodulatory property. This study aimed to investigate the expression and potential role of 1,25(OH)2 D3 in the pathogenesis of diabetic retinopathy (DR) in the Uygur population. Blood samples were obtained from 22 patients with proliferative...

journal_title：IUBMB life

authors： Yi X,Sun J,Li L,Wei Q,Qian Y,Chen X,Ma L

更新日期：2016-06-01 00:00:00

abstract：:Endothelial dysfunction is fundamental to ischemic stroke and brain injury. The humanin analogue S14G-humanin (HNG) has been shown to be a cytoprotective derivative. In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro. In a murine middle cerebral artery occlusion (MCAO) stroke model,...

journal_title：IUBMB life

authors： Peng T,Wan W,Wang J,Liu Y,Fu Z,Ma X,Li J,Sun G,Ji Y,Lu J,Lu H,Liu Y

更新日期：2018-07-01 00:00:00

abstract：:SARS-CoV-2 is the causative agent for the ongoing COVID19 pandemic, and this virus belongs to the Coronaviridae family. Like other members of this family, the virus possesses a positive-sense single-stranded RNA genome. The genome encodes for the nsp12 protein, which houses the RNA-dependent-RNA polymerase (RdRP) acti...

journal_title：IUBMB life

authors： Narayanan N,Nair DT

更新日期：2020-10-01 00:00:00

abstract：:Mitochondria, the energy-producing organelles of the eukaryotic cell, originate from an endosymbiotic alpha-proteobacterium. These organelles are believed to have arisen only once in evolutionary history, but despite their common ancestry, mitochondrial DNAs vary extensively throughout eukaryotes in genome architectur...

journal_title：IUBMB life

authors： Burger G,Lang BF

更新日期：2003-04-01 00:00:00

abstract：:Modern cell-free in vitro protein synthesis systems present powerful tools for the synthesis of isotope-labeled proteins in high yields. The production of selectively 15 N-labeled proteins from 15 N-labeled amino acids is particularly economic and yields are often sufficient to analyze the proteins very quickly by two...

journal_title：IUBMB life

authors： Ozawa K,Dixon NE,Otting G

更新日期：2005-09-01 00:00:00

abstract：:Although vitamin E has been recognized as a critical micronutrient to neuronal health for more than half a century, vitamin E transport and regulation in the brain remain a mystery. Currently, the majority of what is known about vitamin E transport has been delineated in the liver. However, clues from the pathogenesis...

journal_title：IUBMB life

authors： Lee P,Ulatowski LM

更新日期：2019-04-01 00:00:00

abstract：:Induction of apoptosis is the target of choice for modern chemotherapeutic treatment of cancer, where lack of potent "target-specific" drugs has led to extensive research on anticancer compounds from natural sources. In our study, we have used astrakurkurone, a triterpene isolated from wild edible mushroom, Astraeus h...

journal_title：IUBMB life

authors： Dasgupta A,Dey D,Ghosh D,Lai TK,Bhuvanesh N,Dolui S,Velayutham R,Acharya K

更新日期：2019-07-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an enveloped positive-strand RNA virus of the Flaviviridae family. It has a genome of about 9,600 nucleotides encoding a large polyprotein (about 3,000 amino acids) that is processed by cellular and viral proteases into at least 10 structural and nonstructural viral proteins. A novel HCV pro...

journal_title：IUBMB life

authors： Vassilaki N,Mavromara P

更新日期：2009-07-01 00:00:00

abstract：:This review describes recent progress in the field of fibroblast growth factor receptors (FGFRs) with an emphasis on the role of FGFR mutants in skeletal malformations. This family of four receptors contains the most frequent germline mutations in humans. More than 75 mutations have been recorded, which account for mo...

journal_title：IUBMB life

authors： Kannan K,Givol D

更新日期：2000-03-01 00:00:00

abstract：:The 10th jubilee conference (IPK2019) took place on September 15-19, 2019 in Warsaw, on the Ochota campus as the IUBMB Focused Meeting entitled "Inhibitors of Protein Kinases. Kinase inhibitors in target biology and disease". ...

journal_title：IUBMB life

authors： Poznanski J,Fabbro D

更新日期：2020-06-01 00:00:00

abstract：:Researchers have started focusing on investigating the anticarcinogenic effects of natural products with the slightest side effects possible, because current breast cancer treatment approaches are unable to achieve absolute success especially on aggressive subtypes. Propolis is among these products with its antimicrob...

journal_title：IUBMB life

authors： Seyhan MF,Yılmaz E,Timirci-Kahraman Ö,Saygılı N,Kısakesen Hİ,Gazioğlu S,Gören AC,Eronat AP,Begüm Ceviz A,Öztürk T,Yılmaz-Aydoğan H,Öztürk O

更新日期：2019-05-01 00:00:00

abstract：:Lysosomal storage disorders (LSDs) are inherited metabolic diseases caused by deficiencies in lysosomal proteins, which result in accumulation of undegraded metabolites and disruption of lysosomal proteostasis. Despite significant progress in the molecular genetics and biochemistry underlying the cellular pathogenesis...

journal_title：IUBMB life

authors： Segatori L

更新日期：2014-07-01 00:00:00

abstract：:Small noncoding RNAs are key controllers of cellular function, and their deregulation can lead to cancer development and metastatic evolution. This review summarizes the most important examples of small RNAs involved in human cancer and discusses their clinical use as biomarkers and drug targets for diagnosis, prognos...

journal_title：IUBMB life

authors： Rovira C,Güida MC,Cayota A

更新日期：2010-12-01 00:00:00

abstract：:This study examined whether cell cycle regulatory proteins, such as cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors, regulate type II collagen expression and mediate interlukin-1 (IL-1beta)-induced suppression of type II collagen expression in articular chondrocytes. IL-1beta inhibited type II collagen ex...

journal_title：IUBMB life

authors： Hwang SG,Song SM,Kim JR,Park CS,Song WK,Chun JS

更新日期：2007-02-01 00:00:00