Abstract:
:The immunosuppressant cyclosporin A (CsA)-sensitive nuclear factor of activated T cells 1 (NFAT1) has been known to be a transcriptional regulator of cytokine and viral genes during the immune response. By analyses of serial deletion, mutation, and heterologous promoter assay, we report here that the CsA-sensitive NFAT1-C represses the transcriptional activity of enhancer II and pregenomic promoter (EnII/Cp) of HBV through the NFAT1-C responsive site (GGAGA, nt 1603-1618) and nullifies the HBx-driven transcriptional activation of the EnII/Cp of HBV in a dose-dependent manner. These results suggest that a CsA-sensitive NFAT1-C may control the viral activity in HBV-infected cells by inhibiting the EII/Cp and nullifying the HBx-driven transcriptional activation.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Lee JH,Rho HMdoi
10.1080/152165401753311807keywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
255-61issue
4eissn
1521-6543issn
1521-6551journal_volume
51pub_type
杂志文章相关文献
IUBMB LIFE文献大全abstract::Ten-eleven translocation (TET) family enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine in DNA. However, the role of TET enzymes in human gastric cancer remains unknown. Here, we show that TET2 mRNA and protein levels are downregulated in human gastric cancer tissues when compared with normal gastric mucosa....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1490
更新日期:2016-05-01 00:00:00
abstract::T cell (TC) activation requires the coordinated signaling of the T cell receptor (TCR) and coreceptor molecules, allowing TCs to respond to lower degrees of TCR occupancy. Coreceptor molecules set the threshold for TC activation by controlling different regulatory signaling loops. The Cbl family members prevent undesi...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.554
更新日期:2011-10-01 00:00:00
abstract::Cellular nucleic acid binding protein (CNBP) has been implicated in vertebrate craniofacial development and in myotonic dystrophy type 2 (DM2) and sporadic inclusion body myositis (sIBM) human diseases. In these seemingly unrelated biological processes, CNBP appears to be involved in controlling cell death and prolife...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.379
更新日期:2010-10-01 00:00:00
abstract::The current landscapes of novel therapeutic approaches rely mostly on gene-targeted technologies, enabling to fight rare genomic diseases, from infections to cancer and hereditary diseases. Although, reaching the action-site for this novel treatments requires to deliver nucleic acids, or other macromolecules into cell...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1257
更新日期:2014-03-01 00:00:00
abstract::Treatment of microsomes (preferably enriched with endoplasmic reticulum) isolated from bovine pulmonary artery smooth muscle tissue with the O2*- -generating system (hypoxanthine (HPX) plus xanthine oxidase (XO)), markedly stimulated matrix metalloproteinase-2 (MMP-2) activity and also enhanced Ca2+ ATPase activity an...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/1521654041000171335
更新日期:2004-05-01 00:00:00
abstract::Worldwide, one of the most prevalent forms of chronic disease is alcoholic fatty liver, which may progress to more severe forms of liver injury including steatohepatitis, fibrosis, and cirrhosis. The molecular mechanisms by which ethanol consumption causes accumulation of hepatic lipid are multiple and complex. Chroni...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.124
更新日期:2008-12-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders; however, its pathophysiology is still unclear. Certain polymorphisms of luteinizing hormone beta-subunit (LHβ) and LH/choriogonadotrophin receptor (LHCGR) genes may lead to changes in the bioactivity of this hormone. We aimed to ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1457
更新日期:2016-01-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized by the presence of senile plaques and neurofibrillary tangles in the brain. The beta-amyloid peptide (Abeta) is the primary constituent of the senile plaques, and has been proposed to be a key contributor to the neurodegeneration observed in AD. The molecular mechanisms underl...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.308
更新日期:2010-03-01 00:00:00
abstract::The pathogenetic mechanism of the most extensively investigated A3243G mutated tRNALeu(UUR) gene, which causes the MELAS encephalomyopathy, maternally inherited diabetes, or chronic progressive external ophlthalmoplegia, is still unresolved, despite the numerous investigations on the topic. Previous evidences presente...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/1521654031000110190
更新日期:2003-03-01 00:00:00
abstract::Interferon regulatory factors (IRFs) were originally discovered in the context of type I interferon (IFN-alpha/beta) gene induction, and subsequent studies on these transcription factors have revealed their remarkable functional diversity in regulating immune systems. Indeed, the critical involvement of IRF members in...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540600702206
更新日期:2006-05-01 00:00:00
abstract::Transfer RNAs require essential maturation steps to become functional. Among them, RNase P removes 5' leader sequences of pre-tRNAs. Although RNase P was long thought to occur universally as ribonucleoproteins, different types of protein-only RNase P enzymes were discovered in both eukaryotes and prokaryotes. Interest...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2062
更新日期:2019-08-01 00:00:00
abstract::The acidic phospholipase A2 isoform from the spitting cobra Naja mossambica mossambica is activated irreversibly by treatment with a molar equivalent of oleoyl imidazolide. The kinetics of the chemical modification of the enzyme can also be monitored by measuring the large reduction of tryptophan fluorescence, which i...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803513
更新日期:1999-09-01 00:00:00
abstract::Arginine biosynthesis pathway is crucial to the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). Arginine is a critical amino acid that contributes to the inflection of cellular immune responses during pathogenesis. Argininosuccinate lyase from Mtb (MtArgH), the last enzyme in the pathway, catalyzes the ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1683
更新日期:2017-11-01 00:00:00
abstract::Increasing evidence suggests a role for intracellular reactive oxygen species (ROS) as mediators of normal and pathological signal transduction pathways. In particular, a growing list of recent reports have demonstrated a rapid and significant increases in intracellular ROS following growth factor or cytokine stimulat...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540252774694
更新日期:2001-07-01 00:00:00
abstract::Over the years, microRNA-20b-3p (miR-20b-3p) has been found to play an essential role in human diseases; we aimed to investigate the effect of miR-20b-3p on the progression of diabetic retinopathy (DR). The DR rat models were established by streptozotocin injection and treated with miR-20b-3p mimics, silenced, or over...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2267
更新日期:2020-07-01 00:00:00
abstract::Cooperative effects in ligand binding and dissociation kinetics are much less investigated than steady state kinetics or equilibrium binding. Nevertheless, cooperativity in ligand binding leads necessarily to characteristic properties with respect to kinetic properties of the system. In case of positive cooperativity ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.459
更新日期:2011-05-01 00:00:00
abstract::The purpose of this study was to confirm protein-protein interaction between cyclooxygenase-1 (COX-1) and caveolins. The interaction of cyclooxygenase-1 and caveolins in the cultured human embryonic kidney (HEK 293) cells was investigated using immuno-precipitation and Western blot analysis. In HEK 293 cells, high lev...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540410001699312
更新日期:2004-04-01 00:00:00
abstract::Exosomes are nano-sized extracellular vesicles containing a cell-specific biologically active cargo of proteins and genetic materials. Exosomes are constitutively released from almost all cell-types and affect neighboring or distant cells through a complex intercellular exchange of the genetic information and/or regul...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2396
更新日期:2020-12-01 00:00:00
abstract::The physiological role of neuroglobin and cytoglobin, two vertebrate globins discovered in the last 5 years, is not yet clearly understood. In this work, we review the structural information on these globins and its implication on the possible protein function, obtained by electron paramagnetic resonance and resonance...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540500037877
更新日期:2004-11-01 00:00:00
abstract::The pathophysiology of some inflammatory arterial diseases (such as vasculitis, atherogenesis and aneurysms) has been widely investigated in the last decades. Among different soluble molecules, proinflammatory cytokines (such as TNF-α, IL-1 and IL-6) were shown to trigger critical pathways regulating these arterial di...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1344
更新日期:2015-01-01 00:00:00
abstract::Release of arachidonic acid from membrane glycerophospholipids by cytosolic phospholipase A2 (cPLA2) is a key step in the generation of platelet-activating factor (PAF), recognized as the most proximal mediator of inflammatory events triggered by bacterial infection. Here, we report on the role of cPLA2 in the disturb...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540600732021
更新日期:2006-04-01 00:00:00
abstract::The generation of free radicals and the resulting oxidative modification of cell structures are omnipresent in mammalian cells. This includes the permanent oxidation of proteins leading to the disruption of the protein structure and an impaired functionality. In consequence, these oxidized proteins have to be removed ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.114
更新日期:2008-11-01 00:00:00
abstract::SARS-CoV-2 is the causative agent for the ongoing COVID19 pandemic, and this virus belongs to the Coronaviridae family. Like other members of this family, the virus possesses a positive-sense single-stranded RNA genome. The genome encodes for the nsp12 protein, which houses the RNA-dependent-RNA polymerase (RdRP) acti...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2359
更新日期:2020-10-01 00:00:00
abstract::1,25-Dihydroxyvitamin D3 [1,25(OH)2 D3 ] has recently been shown to have immunomodulatory property. This study aimed to investigate the expression and potential role of 1,25(OH)2 D3 in the pathogenesis of diabetic retinopathy (DR) in the Uygur population. Blood samples were obtained from 22 patients with proliferative...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1501
更新日期:2016-06-01 00:00:00
abstract::In many organisms the processes of DNA replication and recombination are closely linked. For instance, in bacterial and eukaryotic systems, replication forks can become stalled or damaged, in many cases leading to the formation of double stranded breaks. Replication restart is an essential mechanism in which the recom...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540310001612237
更新日期:2003-08-01 00:00:00
abstract::Acid fibroblast growth factor (aFGF) binds to its cell-surface receptors in a heparin-dependent manner. In an attempt to define the aFGF recognition site on fibroblast growth factor receptor 1 (FGFR1), we developed a screening strategy for identifying FGF ligands that bind to the receptor-binding region of FGF. To ret...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540050167106
更新日期:2000-06-01 00:00:00
abstract::Recent successes in identifying the genes and associated proteins underlying several familial neurodegenerative conditions have not always resulted in accounts as to why the associated patterns of neuronal damage are so specific and limited. Here, with reference to Huntington's disease, we present a general scheme to ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/1521654031000153012
更新日期:2003-06-01 00:00:00
abstract::Mutations in the breast cancer susceptibility gene BRCA1 predispose individuals to breast and ovarian cancers. Cofactor of BRCA1 (COBRA1), a novel protein, was isolated as a BRCA1-interacting protein. However, the role of COBRA1 in breast cancer is poorly understood. In this study, we demonstrate that COBRA1 mRNA was ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540410001699826
更新日期:2004-03-01 00:00:00
abstract::The expression of the cytM gene, which encodes cytochrome cM in Synechocystis sp. PCC 6803, is induced under stress conditions such as low temperature. Results of spectrophotometric studies revealed that cytochrome cM was oxidized by light absorbed by photosystem I in cells that had acclimatized to a low temperature. ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540118716
更新日期:2001-02-01 00:00:00
abstract::Myocardial ischemia/reperfusion (I/R) injury greatly contributes to myocardial tissue damage in patients with coronary disease, which eventually leads to heart failure. Long noncoding RNAs (lncRNAs) have an emerging role in the process of myocardial I/R injury. Our previous work revealed the protective role of miR-374...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2428
更新日期:2020-12-09 00:00:00