Abstract:
:The physiological role of neuroglobin and cytoglobin, two vertebrate globins discovered in the last 5 years, is not yet clearly understood. In this work, we review the structural information on these globins and its implication on the possible protein function, obtained by electron paramagnetic resonance and resonance Raman spectroscopy. All studies reveal a high flexibility in the heme-pocket region of neuroglobin. Together with the observation that the distal ligand of the heme iron is the endogenous E7-histidine in both the ferric and ferrous form of neuroglobin and cytoglobin, the flexibility of the heme environment in neuroglobin will play a crucial role in the globins' ability to bind and stabilize exogenous ligands.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Van Doorslaer S,Vinck E,Trandafir F,Ioanitescu I,Dewilde S,Moens Ldoi
10.1080/15216540500037877keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
665-70issue
11-12eissn
1521-6543issn
1521-6551pii
H271740271303331journal_volume
56pub_type
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