Abstract:
:The members of the GATA family of transcription factors have homologous zinc fingers and bind to similar sequence motifs. Recent advances in genome-wide technologies and the integration of bioinformatics data have led to a better understanding of how GATA factors regulate gene expression; GATA-factor-induced transcriptional and epigenetic changes have now been analyzed at unprecedented levels of detail. Here, we review the results of genome-wide studies of GATA factor occupancy in human and murine cell lines and primary cells (as determined by chromatin immunoprecipitation sequencing), and then discuss the molecular mechanisms underlying the mediation of transcriptional and epigenetic regulation by GATA factors.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Romano O,Miccio Adoi
10.1002/iub.2169subject
Has Abstractpub_date
2020-01-01 00:00:00pages
10-26issue
1eissn
1521-6543issn
1521-6551journal_volume
72pub_type
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