Conformational stability and thermodynamic characterization of homotetrameric Plasmodium falciparum beta-ketoacyl-ACP reductase.

abstract：:The functional effect of the interaction of E2F1 and hepatitis B virus X protein (HBx) on the promoter of human p53 gene was studied using chloramphenicol acetyl transferase (CAT) assay. E2F1 activated the p53 promoter through E2F1 binding site. As previously reported, HBx repressed the p53 promoter through E-box. Whe...

journal_title：IUBMB life

authors： Choi M,Lee H,Rho HM

更新日期：2002-06-01 00:00:00

abstract：:In vivo site-directed mutagenesis by single-stranded deoxyribonucleic acid recombineering is a facile method to change the color of fluorescent proteins (FPs) without cloning. Two different starting alleles of GFP were targeted for mutagenesis: gfpmut3* residing in the Escherichia coli genome and egfp carried by a bac...

journal_title：IUBMB life

authors： Valledor M,Hu Q,Schiller P,Myers RS

更新日期：2012-08-01 00:00:00

abstract：:Cell-surface-bound extracellular DNA (csbDNA) is present on the outer membrane of blood cells, including both red blood cells and leukocytes. Although less well characterized than cell-free DNA (cfDNA) in plasma and serum, leukocyte and red blood cell csbDNA form a considerable fraction of the blood extracellular nucl...

journal_title：IUBMB life

authors： Tamkovich S,Laktionov P

更新日期：2019-09-01 00:00:00

abstract：:Cooperative effects in ligand binding and dissociation kinetics are much less investigated than steady state kinetics or equilibrium binding. Nevertheless, cooperativity in ligand binding leads necessarily to characteristic properties with respect to kinetic properties of the system. In case of positive cooperativity ...

journal_title：IUBMB life

authors： Hellmann N

更新日期：2011-05-01 00:00:00

abstract：:Selenium is an essential component of several enzymes and proteins in a number of methane-producing archae. Information concerning accessory proteins that function in selenium transport processes, however, is limited. A novel selenium-binding protein with a potential transport role and a selenocysteine lyase that serv...

journal_title：IUBMB life

authors： Stadtman T

更新日期：2004-07-01 00:00:00

abstract：:The expression of the cytM gene, which encodes cytochrome cM in Synechocystis sp. PCC 6803, is induced under stress conditions such as low temperature. Results of spectrophotometric studies revealed that cytochrome cM was oxidized by light absorbed by photosystem I in cells that had acclimatized to a low temperature. ...

journal_title：IUBMB life

authors： Shuvalov VA,Allakhverdiev SI,Sakamoto A,Malakhov M,Murata N

更新日期：2001-02-01 00:00:00

abstract：:The aggressive biological behavior of invasive and metastatic cancer is considered to be the most insidious and life-threatening aspect for breast cancer patients. It is mostly the result of changes in many molecular characteristics of tumor cells, including alterations in gene expression and the balance of proteolyti...

journal_title：IUBMB life

authors： Swellam M,Arab LR,Bushnak HA

更新日期：2007-06-01 00:00:00

abstract：:The mammalian antizyme (AZ) promotes ubiqutin-independent degradation of ornithine decarboxylase, a key enzyme in polyamine biosynthesis. This study shows that AZ suppression in human lung carcinoma A549 cells caused growth defects and death, but made the cells resistant to DNA damaging agents such as gamma-radiation ...

journal_title：IUBMB life

authors： Kim JS,Kim TL,Cho EW,Paik SG,Chung HW,Kim IG

更新日期：2008-06-01 00:00:00

abstract：:In this study, we intended to determine the detailed function and mechanism of long noncoding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) in liver injury induced by sepsis. Cecal ligation and perforation (CLP) models were adopted to induce sepsis in vivo with rats, and hepatic epithelial cells L...

journal_title：IUBMB life

authors： Li Y,Song J,Xie Z,Liu M,Sun K

更新日期：2020-03-01 00:00:00

abstract：:Pancreatic islet beta-cells are poised to generate metabolic messengers in the mitochondria that link glucose metabolism to insulin exocytosis. This is accomplished through the tight coupling of glycolysis to mitochondrial activation. The messenger molecules ATP and glutamate are produced after the metabolism of glyco...

journal_title：IUBMB life

authors： Ishihara H,Wollheim CB

更新日期：2000-05-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with impairments in social communication, restricted, repetitive and stereotyped behaviors. Both genetic and environmental factors are known to contribute toward pathophysiology of Autism. Environmental influences on gene expression can be mediate...

journal_title：IUBMB life

authors： Alex AM,Saradalekshmi KR,Shilen N,Suresh PA,Banerjee M

更新日期：2019-07-01 00:00:00

abstract：:In most organisms, productive utilization of galactose requires the highly conserved Leloir pathway of galactose metabolism. Yet, if this metabolic pathway is perturbed due to congenital deficiencies of the three associated enzymes, or an overwhelming presence of galactose, this monosaccharide which is abundantly pres...

journal_title：IUBMB life

authors： Lai K,Elsas LJ,Wierenga KJ

更新日期：2009-11-01 00:00:00

abstract：:Cyclic AMP metabolism is essential for the survival of the social amoebae Dictyostelium discoideum. Three distinct adenylyl cyclases are expressed and required for the normal development of this simple eukaryote. The adenylyl cyclase expressed during aggregation, ACA, is related to the mammalian and Drosophila G prote...

journal_title：IUBMB life

authors： Kriebel PW,Parent CA

更新日期：2004-09-01 00:00:00

abstract：:The invasion and chemoresistance are crucial causes of morbidity and relapse for cancer patients. Axl is implicated in the modulation of cell invasion, cancer metastasis, and chemosensitivity in human breast carcinoma cell lines. Both breast cancer cell lines and tissues displayed increased expression of Axl, and it o...

journal_title：IUBMB life

authors： Li Y,Jia L,Ren D,Liu C,Gong Y,Wang N,Zhang X,Zhao Y

更新日期：2014-07-01 00:00:00

abstract：:Mitochondria, the energy-producing organelles of the eukaryotic cell, originate from an endosymbiotic alpha-proteobacterium. These organelles are believed to have arisen only once in evolutionary history, but despite their common ancestry, mitochondrial DNAs vary extensively throughout eukaryotes in genome architectur...

journal_title：IUBMB life

authors： Burger G,Lang BF

更新日期：2003-04-01 00:00:00

abstract：:Synucleinopathies are neurodegenerative diseases characterized by the accumulation of either neuronal/axonal or glial insoluble proteinaceous aggregates mainly composed of α-synuclein (α-syn). Among them, the most common disorders are Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and some fo...

journal_title：IUBMB life

authors： Longhena F,Faustini G,Brembati V,Pizzi M,Bellucci A

更新日期：2020-04-01 00:00:00

abstract：:Retinitis pigmentosa comprises a large and exceptionally heterogeneous group of hereditary disorders of the retina. As a result of an extensive investigation around the world, primary genetic lesions have been described in many genes. Some of these genes encode enzymes that are involved in the signal transduction path...

journal_title：IUBMB life

authors： Shastry BS

更新日期：2000-06-01 00:00:00

abstract：:Silymarin, which is derived from the seeds of Silybum marianum, has been widely used to prevent and treat liver diseases. In our previous study, we reported that at concentrations above the minimal inhibitory concentration (MIC), silymarin exhibited antifungal activity against Candida albicans by targeting its plasma ...

journal_title：IUBMB life

authors： Lee W,Lee DG

更新日期：2018-03-01 00:00:00

abstract：:Transforming growth factorbeta1 (TGFbeta1) is considered to be the principal contributor to liver fibrosis. So in this study the ribozymes against TGFbeta1 were designed. The in vitro cleavage activities of the ribozymes were assayed through incubation of (32)p-labeled target RNAs and (32)p-labeled ribozymes in differ...

journal_title：IUBMB life

authors： Song YH,Zhou XM,Xue XN,Liu NZ,Tian DA,Kong XJ,Wu XL,Lin JS,Jin YX

更新日期：2005-01-01 00:00:00

abstract：:Increasing evidence suggests a role for intracellular reactive oxygen species (ROS) as mediators of normal and pathological signal transduction pathways. In particular, a growing list of recent reports have demonstrated a rapid and significant increases in intracellular ROS following growth factor or cytokine stimulat...

journal_title：IUBMB life

authors： Finkel T

更新日期：2001-07-01 00:00:00

abstract：:Cartilage engineering is one challenging issue in regenerative medicine. Low oxygen tension or hypoxia inducible factor-1 (HIF-1α) gene therapy are promising strategies in the field of cartilage repair. Previously, we showed that hypoxia and its mediator HIF-1 regulate matrix genes expression (collagens and aggrecan)....

journal_title：IUBMB life

authors： Duval E,Bouyoucef M,Leclercq S,Baugé C,Boumédiene K

更新日期：2016-09-01 00:00:00

abstract：:Cardiovascular disease is a leading cause of morbidity and mortality. Smooth muscle cells (SMC) comprising the vascular wall can switch phenotypes from contractile to synthetic, which can promote the development of aberrant remodelling and intimal hyperplasia (IH). MicroRNA-21 (miR-21) is a short, non-coding RNA that ...

journal_title：IUBMB life

authors： Alshanwani AR,Riches-Suman K,O'Regan DJ,Wood IC,Turner NA,Porter KE

更新日期：2018-07-01 00:00:00

abstract：:Calcineurin (CN) is the only serine/threonine specific protein phosphatase regulated by Ca(2+) /calmodulin (CaM), which is composed of catalytic A subunit (CNA) and regulatory B subunit (CNB). Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is an essential component in the Toll like receptors and TNF ...

journal_title：IUBMB life

authors： Wang X,Huang Y,Li L,Wei Q

更新日期：2012-09-01 00:00:00

abstract：:Researchers have started focusing on investigating the anticarcinogenic effects of natural products with the slightest side effects possible, because current breast cancer treatment approaches are unable to achieve absolute success especially on aggressive subtypes. Propolis is among these products with its antimicrob...

journal_title：IUBMB life

authors： Seyhan MF,Yılmaz E,Timirci-Kahraman Ö,Saygılı N,Kısakesen Hİ,Gazioğlu S,Gören AC,Eronat AP,Begüm Ceviz A,Öztürk T,Yılmaz-Aydoğan H,Öztürk O

更新日期：2019-05-01 00:00:00

abstract：:Fructose 2,6-bisphosphate is a potent metabolic regulator in eukaryotic organisms; it affects the activity of key enzymes of the glycolytic and gluconeogenic pathways. The enzymes responsible for its synthesis and hydrolysis, 6-phosphofructo-2-kinase (PFK-2) and fructose-2,6-bisphosphatase (FBPase-2) are present in re...

journal_title：IUBMB life

authors： Michels PA,Rigden DJ

更新日期：2006-03-01 00:00:00

abstract：:Treatment of microsomes (preferably enriched with endoplasmic reticulum) isolated from bovine pulmonary artery smooth muscle tissue with the O2*- -generating system (hypoxanthine (HPX) plus xanthine oxidase (XO)), markedly stimulated matrix metalloproteinase-2 (MMP-2) activity and also enhanced Ca2+ ATPase activity an...

journal_title：IUBMB life

authors： Mandal A,Chakraborti T,Das S,Ghosh B,Ghosh A,Chakraborti S

更新日期：2004-05-01 00:00:00

abstract：:The rat organic anion transporter 3 (rOAT3) has recently been identified as the third isoform of the OAT family. The mechanisms that regulate rOAT3's functions remain to be elucidated. rOAT3 contributes for moving a number of negatively charged organic compounds between cells and their extracellular milieu. Caveolin (...

journal_title：IUBMB life

authors： Kwak JO,Kim HW,Song JH,Kim MJ,Park HS,Hyun DK,Kim DS,Cha SH

更新日期：2005-02-01 00:00:00

abstract：:Over the past decade, following the discovery of the human heme protein neuroglobin, many studies have searched for evidence for this protein's mechanism of action. Much data has accrued showing that high levels of neuroglobin will protect cells from apoptotic cell death, following a wide range of challenges. Various ...

journal_title：IUBMB life

authors： Brittain T,Skommer J,Henty K,Birch N,Raychaudhuri S

更新日期：2010-12-01 00:00:00

abstract：:The pathophysiology of some inflammatory arterial diseases (such as vasculitis, atherogenesis and aneurysms) has been widely investigated in the last decades. Among different soluble molecules, proinflammatory cytokines (such as TNF-α, IL-1 and IL-6) were shown to trigger critical pathways regulating these arterial di...

journal_title：IUBMB life

authors： Carbone F,Montecucco F

更新日期：2015-01-01 00:00:00

abstract：:Worldwide, one of the most prevalent forms of chronic disease is alcoholic fatty liver, which may progress to more severe forms of liver injury including steatohepatitis, fibrosis, and cirrhosis. The molecular mechanisms by which ethanol consumption causes accumulation of hepatic lipid are multiple and complex. Chroni...

journal_title：IUBMB life

authors： Rogers CQ,Ajmo JM,You M

更新日期：2008-12-01 00:00:00