Abstract:
:Cell-surface-bound extracellular DNA (csbDNA) is present on the outer membrane of blood cells, including both red blood cells and leukocytes. Although less well characterized than cell-free DNA (cfDNA) in plasma and serum, leukocyte and red blood cell csbDNA form a considerable fraction of the blood extracellular nucleic acids pool, with typically at least comparable amount of DNA occurring bound to the outer surface of cells as compared with circulating free DNA in plasma. The cellular origin of csbDNA is not clear; however, as with cfDNA, in patients with cancer a proportion is derived from the tumor, thus making it potentially a useful source of DNA for cancer diagnosis, prognosis, and monitoring. © 2019 IUBMB Life, 71(9):1201-1210, 2019.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Tamkovich S,Laktionov Pdoi
10.1002/iub.2070subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1201-1210issue
9eissn
1521-6543issn
1521-6551journal_volume
71pub_type
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