Abstract：
:Tetrameric haemoglobins display a cooperative ligand binding behaviour, which has been attributed to the functional interrelationship between multiple ligand binding sites. The quantitative description of this feature was initially carried out with a phenomenological approach, which was limited to the functional effect of the occupancy by a ligand molecule of a binding site on further binding steps. However, subsequent development of structural-functional models for the description of the cooperativity in haemoglobin brought about a much deeper information on the interrelationships between ligand binding at the heme and structural variations occurring in the surrounding free subunits. This approach opened the way to the evolution of the concept of allostery, which is intended as the structural-functional effect exerted by the presence of a ligand in a binding site on other binding sites present in the same molecule. This concept can be applied to either sites for the same ligand (homotropic allostery) and for sites of different ligands (heterotropic allostery). Several models trying to take into account the continuous building up of structural and functional information on the physicochemical properties of haemoglobin have been developed along this line.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Ciaccio C,Coletta A,De Sanctis G,Marini S,Coletta Mdoi
10.1002/iub.6subject
Has Abstractpub_date
2008-02-01 00:00:00pages
112-23issue
2eissn
1521-6543issn
1521-6551journal_volume
60pub_type
杂志文章,评审相关文献
IUBMB LIFE文献大全abstract：:Oral squamous cell carcinoma (OSCC) is a lethal malignancy and its prognosis remains dismal. Thus, a deeper understanding of the mechanisms is needed to provide a new insight for new therapies. It has been reported that long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) was downregulated in OSCC tissues, h...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.2012
更新日期：2019-07-01 00:00:00
abstract：:This study examined whether cell cycle regulatory proteins, such as cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors, regulate type II collagen expression and mediate interlukin-1 (IL-1beta)-induced suppression of type II collagen expression in articular chondrocytes. IL-1beta inhibited type II collagen ex...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/15216540701245022
更新日期：2007-02-01 00:00:00
abstract：:Over the years, microRNA-20b-3p (miR-20b-3p) has been found to play an essential role in human diseases; we aimed to investigate the effect of miR-20b-3p on the progression of diabetic retinopathy (DR). The DR rat models were established by streptozotocin injection and treated with miR-20b-3p mimics, silenced, or over...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.2267
更新日期：2020-07-01 00:00:00
abstract：:Although proteins and nucleic acids consist of different chemical components, proteins can mimic structures and possibly also functions of nucleic acids. Recently, structural mimicry was observed between two elongation factors in bacterial protein biosynthesis leading to the introduction of the concept of macromolecul...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/713803471
更新日期：1999-07-01 00:00:00
abstract：:Long noncoding RNAs (lncRNAs) play important roles in the initiation and progression of various cancers, including laryngeal squamous cell carcinoma (LSCC). Recently, lncRNA Sox2 overlapping transcript (SOX2-OT) has been identified as an oncogene in various cancers. However, the functional role and the regulatory mech...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.2026
更新日期：2019-09-01 00:00:00
abstract：:Bladder carcinoma is an important worldwide health problem. Both cystoscopy and urine cytology used in detecting bladder cancer suffer from drawbacks where cystoscopy is an invasive method and urine cytology shows low sensitivity in low-grade tumors. This study validates easier and less time-consuming techniques for t...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.325
更新日期：2010-05-01 00:00:00
abstract：:The direct relationship between obesity and breast cancer has been elucidated recently with the identification of a cholesterol derivative 27-hydroxycholesterol (27HC), an endogenous SERM that can act through estrogen receptor (ER)-mediated mechanisms. Our recent research shed light on the possible SERM-like property ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1465
更新日期：2016-02-01 00:00:00
abstract：:The pathways for ligand entry and exit in myoglobin have now been well established by a wide variety of experimental results, including pico- to nano- to microsecond transient absorbance measurements and time-resolved X-ray crystallographic measurements. Trp insertions have been used to block, one at a time, the three...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540701230495
更新日期：2007-08-01 00:00:00
abstract：:The invasion and chemoresistance are crucial causes of morbidity and relapse for cancer patients. Axl is implicated in the modulation of cell invasion, cancer metastasis, and chemosensitivity in human breast carcinoma cell lines. Both breast cancer cell lines and tissues displayed increased expression of Axl, and it o...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1285
更新日期：2014-07-01 00:00:00
abstract：:Implantation is a complex developmental event that is initiated by recognition and adhesion of the embryo to the endometrial epithelium. sLeX is an oligosaccharide antigen acting as the ligand of L-selectin, and is stage-specifically expressed in the endometrial epithelium. The adhesion system mediated by L-selectin a...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.62
更新日期：2008-07-01 00:00:00
abstract：:The posttranscriptional regulation of miRNAs is important for organism development. To investigate the role of miRNAs in angiogenesis, we performed a loss-of-function screening assay in human umbilical vein endothelial cells (HUVECs) and found that knockdown of 7 miRNAs (miR-95a, miR-126, miR-129, miR-137, miR-139, mi...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.486
更新日期：2011-07-01 00:00:00
abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) is linked to the etiopathogenesis of Kaposi's sarcoma, a plasma-blastic variant of Castleman's disease and primary effusion lymphoma. KSHV is related to a number of non-human primate viruses. Only a limited number of KSHV proteins are expressed in tumor cells. He...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540050022395
更新日期：2000-02-01 00:00:00
abstract：:Silymarin, which is derived from the seeds of Silybum marianum, has been widely used to prevent and treat liver diseases. In our previous study, we reported that at concentrations above the minimal inhibitory concentration (MIC), silymarin exhibited antifungal activity against Candida albicans by targeting its plasma ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1716
更新日期：2018-03-01 00:00:00
abstract：:The 10th jubilee conference (IPK2019) took place on September 15-19, 2019 in Warsaw, on the Ochota campus as the IUBMB Focused Meeting entitled "Inhibitors of Protein Kinases. Kinase inhibitors in target biology and disease". ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.2303
更新日期：2020-06-01 00:00:00
abstract：:Recent advances in the developmental biology, genetics and cell biology of the inner ear are guiding research to novel therapeutic modalities - a market currently estimated to be at least US Dollars 10 billion. This article highlights prospects to manipulate the mammalian hearing organ with gene and stem cell delivery...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540600913258
更新日期：2006-09-01 00:00:00
abstract：:Diarrhea-predominant irritable bowel syndrome (IBS-D) is one of the most common gastrointestinal disorders in the world, lacking effective therapies. The crucial roles of microRNAs (miRNAs) in IBS-D have attracted increasing attention. The aim of this study is to investigate the effects of miR-495 on the visceral sens...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.2270
更新日期：2020-07-01 00:00:00
abstract：:Heparin and its various derivatives affect cancer progression in humans. In this study, we show that heparin uptaken intracellularly by melanoma cells activated a signaling cascade, which in turn inhibited melanoma cell adhesion and migration. The reduced ability of M5 cells to adhere onto the fibronectin (FN) substra...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.421
更新日期：2011-02-01 00:00:00
abstract：:Cell-surface-bound extracellular DNA (csbDNA) is present on the outer membrane of blood cells, including both red blood cells and leukocytes. Although less well characterized than cell-free DNA (cfDNA) in plasma and serum, leukocyte and red blood cell csbDNA form a considerable fraction of the blood extracellular nucl...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.2070
更新日期：2019-09-01 00:00:00
abstract：:The human nuclear estrogen receptors (i.e., ERalpha and ERbeta), as other transcriptional factors, regulate cellular processes inducing genomic events. In addition, the binding of 17beta-estradiol to ERs induces different membrane initiating non-genomic signaling. The non-genomic effects of ER are independent of trans...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/1521654031000081256
更新日期：2003-01-01 00:00:00
abstract：:Cisplatin (CP), as a chemotherapeutic drug, causes nephrotoxicity that has limited the clinical utility of CP. Gliclazide (GLZ), as an antihyperglycemic drug, at low dose has antioxidant property. In this study, we aimed to investigate the protective effect of GLZ against CP-induced acute renal injury. Sixty-four BALB...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.2342
更新日期：2020-09-01 00:00:00
abstract：:Insulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase Akt/mammalian target of rapamycin (mTOR), Ras/Raf/extracellular signal-regulated kinase (ERK), and phosph...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.1172
更新日期：2013-07-01 00:00:00
abstract：:S-Nitrosation is rapidly emerging as a regulatory mechanism in vascular biology, with particular importance in the onset of hyperpermeability induced by pro-inflammatory agents. This review focuses on the role of endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) in regulating S-Nitrosation of adherens...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.1204
更新日期：2013-10-01 00:00:00
abstract：:We hypothesize that the various, previously reported, reactivities of neuroglobin with redox partners and oxygen provide for the establishment of a redox cycle within cells, such as neurons and retinal rod cells. Using native cell lysates, from cultured human cells of neuronal origin, we have estimated the rate of red...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.566
更新日期：2012-05-01 00:00:00
abstract：:Alkyl-dihydroxyacetonephosphate synthase (alkyl-DHAP synthase) is a peroxisomal enzyme that plays a key role in ether phospholipid biosynthesis. To determine the turnover of alkyl-DHAP synthase in several peroxisomal disorders, pulse-chase experiments were performed. In control fibroblasts, mature alkyl-DHAP synthase ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/713803571
更新日期：1999-12-01 00:00:00
abstract：:Transketolase (TK, EC 2.2.1.1), the key enzyme of the non-oxidative branch of pentose phosphate pathway of hydrocarbon transformation, plays an important role in a system of substrate rearrangement between pentose shunt and glycolysis, acting as a reversible link between the two metabolic pathways. In addition, it sup...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.395
更新日期：2010-11-01 00:00:00
abstract：:Interplay between the apoptosis, DNA damage, and oxidative stress as a host response to dengue viral infections remains unclear. Peripheral blood mononuclear cells (PBMCs) were isolated from 60 dengue infected patients, 20 patients with febrile illness other than dengue (OFI) and 10 non-febrile illness (NFI) patients....
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1925
更新日期：2018-11-01 00:00:00
abstract：:Cellular nucleic acid binding protein (CNBP) has been implicated in vertebrate craniofacial development and in myotonic dystrophy type 2 (DM2) and sporadic inclusion body myositis (sIBM) human diseases. In these seemingly unrelated biological processes, CNBP appears to be involved in controlling cell death and prolife...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.379
更新日期：2010-10-01 00:00:00
abstract：:Recent successes in identifying the genes and associated proteins underlying several familial neurodegenerative conditions have not always resulted in accounts as to why the associated patterns of neuronal damage are so specific and limited. Here, with reference to Huntington's disease, we present a general scheme to ...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/1521654031000153012
更新日期：2003-06-01 00:00:00
abstract：:Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to this process. Its activity is modulated in a coordinated manner via a ...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.411
更新日期：2011-01-01 00:00:00
abstract：:Mutations in the breast cancer susceptibility gene BRCA1 predispose individuals to breast and ovarian cancers. Cofactor of BRCA1 (COBRA1), a novel protein, was isolated as a BRCA1-interacting protein. However, the role of COBRA1 in breast cancer is poorly understood. In this study, we demonstrate that COBRA1 mRNA was ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/15216540410001699826
更新日期：2004-03-01 00:00:00
