Abstract:
:The human nuclear estrogen receptors (i.e., ERalpha and ERbeta), as other transcriptional factors, regulate cellular processes inducing genomic events. In addition, the binding of 17beta-estradiol to ERs induces different membrane initiating non-genomic signaling. The non-genomic effects of ER are independent of transcriptional activity of the receptor and have been attributed to membrane ERs belonging to a signaling complex localized in caveolae. Here, we postulate that S-acylation of cysteine residue(s) present in the ligand binding domain of ERalpha and ERbeta may play a critical role in the membrane caveolar localization of the receptor and in the formation of the 'steroid signalosome'.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Acconcia F,Bocedi A,Ascenzi P,Marino Mdoi
10.1080/1521654031000081256keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
33-5issue
1eissn
1521-6543issn
1521-6551journal_volume
55pub_type
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