Abstract:
:In Streptomyces fradiae, calcium ions induce alterations in intensity and specificity of the secondary metabolism and stimulate sporulation. Using in vivo labeling, we demonstrate that in S. fradiae phosphorylation of some proteins are also influenced by Ca2+ added exogenously. Calcium ions at physiological concentration increase phosphorylation of multiple proteins on serine/threonine residues and suppress modification of a 140-kDa protein on tyrosine residues. Assay of protein kinases in situ demonstrated that Ca2+-induced differences in the pattern of protein phosphorylation in vivo are accompanied by Ca2+-dependent cessation of autophosphorylation of 140-kDa tyrosine kinase and by increased autophosphorylation of three serine/threonine kinases with molecular masses of 127, 65, and 31.5 kDa.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Elizarov SM,Mironov VA,Danilenko VNdoi
10.1080/713803699keywords:
subject
Has Abstractpub_date
2000-08-01 00:00:00pages
139-43issue
2eissn
1521-6543issn
1521-6551journal_volume
50pub_type
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