Human heart cytosolic reductases and anthracycline cardiotoxicity.

abstract：:Oral squamous cell carcinoma (OSCC) is a common malignant cancer with unfavorable prognosis, and the epithelial-to-mesenchymal transition (EMT) is a critical contributor to OSCC metastasis. Recently, we have shown that sirtuin 7 (Sirt7) is associated with EMT and OSCC metastasis by acetylating small mother against dec...

journal_title：IUBMB life

authors： Jia B,Zhang S,Wu S,Zhu Q,Li W

更新日期：2020-12-16 00:00:00

abstract：:Although the amino acid sequences and the structures of pyruvate kinase (PYK) isozymes are highly conserved, allosteric regulations differ. This suggests that amino acids with low conservation play important roles in the allosteric mechanism. The current work exploits a 'natural screen'- the 122 point mutations identi...

journal_title：IUBMB life

authors： Pendergrass DC,Williams R,Blair JB,Fenton AW

更新日期：2006-01-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with impairments in social communication, restricted, repetitive and stereotyped behaviors. Both genetic and environmental factors are known to contribute toward pathophysiology of Autism. Environmental influences on gene expression can be mediate...

journal_title：IUBMB life

authors： Alex AM,Saradalekshmi KR,Shilen N,Suresh PA,Banerjee M

更新日期：2019-07-01 00:00:00

abstract：:Recently the crystal structure of creatine kinase from Torpedocalifornica was determined to 2.1 A. The dimeric structure revealed two different forms in the unit cell: one monomer was bound to a substrate, MgADP, and the other monomer was bound to a transition-state analogue complex composed of MgADP, nitrate and crea...

journal_title：IUBMB life

authors： Wang PF,Flynn AJ,McLeish MJ,Kenyon GL

更新日期：2005-04-01 00:00:00

abstract：:Reactive oxygen and nitrogen species (ROS and RNS) have been extensively recognized as important signaling molecules implicated in physiological processes such as gene expression, cell differentiation and immune activation. Nevertheless, continuous production of these species may produce oxidative and/or nitrosative s...

journal_title：IUBMB life

authors： Rotilio G,Aquilano K,Ciriolo MR

更新日期：2003-10-01 00:00:00

abstract：:Heat shock proteins (Hsps) are a highly conserved family of proteins. The regulation of expression of Hsps in Mycobacterium tuberculosis, is regulated both positively and negatively by alternate sigma factors and transcriptional DNA repressors, respectively. HspR is a negative regulator of expression of hsps, DnaK, Cl...

journal_title：IUBMB life

authors： Parijat P,Batra JK

更新日期：2015-11-01 00:00:00

abstract：:Shiga toxin (Stx) producing Escherichia coli (STEC) is responsible to bloody diarrhea (hemorrhagic colitis) and the hemolytic uremic syndrome (HUS). STEC strains carry inducible lambda phages integrated into their genomes that encode Stx 1 and/or 2, with several allelic variants each one. O157:H7 is the serotype that ...

journal_title：IUBMB life

authors： Ibarra C,Amaral MM,Palermo MS

更新日期：2013-10-01 00:00:00

abstract：:Magnetic targeting has shown promise to improve the efficacy and safety of different classes of therapeutic agents by enabling their active guidance to the site of disease and minimizing dissemination to nontarget tissues. However, its translation into clinic has proven difficult because of inherent limitations of tra...

journal_title：IUBMB life

authors： Chorny M,Fishbein I,Forbes S,Alferiev I

更新日期：2011-08-01 00:00:00

abstract：:Renal ischemia/reperfusion (I/R) is an alternation of renal hemodynamics, which results in diverse postischemic responses and eventually acute kidney injury. Although renal ischemic preconditioning (IPC) is known to protect the kidney from I/R injury, the precise renoprotective mechanisms are not completely understood...

journal_title：IUBMB life

authors： Li JR,Ou YC,Wu CC,Wang JD,Lin SY,Wang YY,Chen WY,Chen CJ

更新日期：2019-03-01 00:00:00

abstract：:Selenium is an essential component of several enzymes and proteins in a number of methane-producing archae. Information concerning accessory proteins that function in selenium transport processes, however, is limited. A novel selenium-binding protein with a potential transport role and a selenocysteine lyase that serv...

journal_title：IUBMB life

authors： Stadtman T

更新日期：2004-07-01 00:00:00

abstract：:Sirolimus(SRL, Rapamune(â), rapamycin) is a highly specific inhibitor of mammalian target of rapamycin (mTOR). Sirolimus exerts its biological activity by inhibiting the serine-threonine kinase mammalian target of rapamycin (mTOR), which regulates important cellular processes such as control of cell cycle, cell size, ...

journal_title：IUBMB life

authors： Wang Y,Zhao Q,Ma S,Yang F,Gong Y,Ke C

更新日期：2007-11-01 00:00:00

abstract：:Over the years, microRNA-20b-3p (miR-20b-3p) has been found to play an essential role in human diseases; we aimed to investigate the effect of miR-20b-3p on the progression of diabetic retinopathy (DR). The DR rat models were established by streptozotocin injection and treated with miR-20b-3p mimics, silenced, or over...

journal_title：IUBMB life

authors： Wang S,Du S,Lv Y,Wang W,Zhang F

更新日期：2020-07-01 00:00:00

abstract：:Cocaine is a powerful central nervous stimulant and among the most abused of drugs. Despite decades of efforts, however, no effective pharmacological treatments are available against cocaine addiction or toxic effects. Classical receptor-antagonist therapeutic approaches have not yielded significant effects, although ...

journal_title：IUBMB life

authors： Ascenzi P,Clementi E,Polticelli F

更新日期：2003-07-01 00:00:00

abstract：:Nasal-type natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy with poor survival outcomes that is relatively resistant to chemotherapy. N6-Methyladenosine (m6A) modification, the most prevalent modification of eukaryotic messenger RNA, is involved in the progression of various tumors. However, it is un...

journal_title：IUBMB life

authors： Ma H,Shen L,Yang H,Gong H,Du X,Li J

更新日期：2020-11-17 00:00:00

abstract：:Bladder carcinoma is an important worldwide health problem. Both cystoscopy and urine cytology used in detecting bladder cancer suffer from drawbacks where cystoscopy is an invasive method and urine cytology shows low sensitivity in low-grade tumors. This study validates easier and less time-consuming techniques for t...

journal_title：IUBMB life

authors： Eissa S,Shabayek MI,Ismail MF,El-Allawy RM,Hamdy MA

更新日期：2010-05-01 00:00:00

abstract：:In most organisms, productive utilization of galactose requires the highly conserved Leloir pathway of galactose metabolism. Yet, if this metabolic pathway is perturbed due to congenital deficiencies of the three associated enzymes, or an overwhelming presence of galactose, this monosaccharide which is abundantly pres...

journal_title：IUBMB life

authors： Lai K,Elsas LJ,Wierenga KJ

更新日期：2009-11-01 00:00:00

abstract：:Fascin actin-bundling protein 1 (FSCN1) is an evolutionarily conserved actin-bundling protein that plays a critical role in cell migration, motility, adhesion, and cellular interactions. Although multiple clinical studies have implicated the expression of FSCN1 in laryngeal squamous cell carcinoma (LSCC) progression, ...

journal_title：IUBMB life

authors： Liu H,Cui J,Zhang Y,Niu M,Xue X,Yin H,Tang Y,Dai L,Dai F,Guo Y,Wu Y,Gao W

更新日期：2019-11-01 00:00:00

abstract：:The mitochondrial ATP-Mg/Pi carrier is responsible for the calcium-dependent regulation of adenosine nucleotide concentrations in the mitochondrial matrix, which allows mitochondria to respond to changing energy requirements of the cell. The carrier is expressed in mitochondria of fungi, plants and animals and belongs...

journal_title：IUBMB life

authors： Harborne SPD,Kunji ERS

更新日期：2018-12-01 00:00:00

abstract：:Arginine biosynthesis pathway is crucial to the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). Arginine is a critical amino acid that contributes to the inflection of cellular immune responses during pathogenesis. Argininosuccinate lyase from Mtb (MtArgH), the last enzyme in the pathway, catalyzes the ...

journal_title：IUBMB life

authors： Mishra A,Surolia A

更新日期：2017-11-01 00:00:00

abstract：:Increasing evidence suggests a role for intracellular reactive oxygen species (ROS) as mediators of normal and pathological signal transduction pathways. In particular, a growing list of recent reports have demonstrated a rapid and significant increases in intracellular ROS following growth factor or cytokine stimulat...

journal_title：IUBMB life

authors： Finkel T

更新日期：2001-07-01 00:00:00

abstract：:The conformational stability of the homotetrameric Plasmodium falciparum beta-ketoacyl-ACP reductase (FabG) was determined by guanidinium chloride-induced isothermal and thermal denaturation. The reversible unfolding transitions were monitored by intrinsic fluorescence, circular dichroism (CD) spectroscopy and by meas...

journal_title：IUBMB life

authors： Karmodiya K,Sajad S,Sinha S,Maity K,Suguna K,Surolia N

更新日期：2007-07-01 00:00:00

abstract：:Copper has a wide and important role in biological systems, determining conformation and activity of many metalloproteins and enzymes, such as cytochrome oxidase and superoxide dismutase . Furthermore, due to its possible reactivity with nonspecific proteins and toxic effects, elaborate systems of absorption, concentr...

journal_title：IUBMB life

authors： Inesi G

更新日期：2017-04-01 00:00:00

abstract：:How should a protein be designed to serve in processes as diverse as chromosome condensation, sister chromatid cohesion, DNA recombination, gene dosage regulation, and perhaps even gene silencing or transcriptional regulation--which occur in both mitosis and meiosis? Such a protein or protein complex needs to bear DNA...

journal_title：IUBMB life

authors： Jessberger R

更新日期：2003-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating neurodegenerative disorder that results in loss of memory and cognitive function, eventually leading to dementia. A key neuropathological event in AD is the cerebral accumulation of senile plaques formed by aggregates of amyloid-β-peptides (Aβ). Aβ results from two sequential ...

journal_title：IUBMB life

authors： Tamagno E,Guglielmotto M,Monteleone D,Vercelli A,Tabaton M

更新日期：2012-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an enveloped positive-strand RNA virus of the Flaviviridae family. It has a genome of about 9,600 nucleotides encoding a large polyprotein (about 3,000 amino acids) that is processed by cellular and viral proteases into at least 10 structural and nonstructural viral proteins. A novel HCV pro...

journal_title：IUBMB life

authors： Vassilaki N,Mavromara P

更新日期：2009-07-01 00:00:00

abstract：:Over the past decade, following the discovery of the human heme protein neuroglobin, many studies have searched for evidence for this protein's mechanism of action. Much data has accrued showing that high levels of neuroglobin will protect cells from apoptotic cell death, following a wide range of challenges. Various ...

journal_title：IUBMB life

authors： Brittain T,Skommer J,Henty K,Birch N,Raychaudhuri S

更新日期：2010-12-01 00:00:00

abstract：:Heart disease is the most common cause of morbidity and mortality in Western society and the incidence is projected to increase significantly over the next few decades as our population ages. Heart failure occurs when the heart is unable to pump blood at a rate to commensurate with tissue metabolic requirements and re...

journal_title：IUBMB life

authors： Graham RM,Bishopric NH,Webster KA

更新日期：2002-08-01 00:00:00

abstract：:In vivo site-directed mutagenesis by single-stranded deoxyribonucleic acid recombineering is a facile method to change the color of fluorescent proteins (FPs) without cloning. Two different starting alleles of GFP were targeted for mutagenesis: gfpmut3* residing in the Escherichia coli genome and egfp carried by a bac...

journal_title：IUBMB life

authors： Valledor M,Hu Q,Schiller P,Myers RS

更新日期：2012-08-01 00:00:00

abstract：:Accumulating evidence indicates that there is a critical role of the ubiquitin/proteasome pathway in the regulation of apoptosis. Among the important molecules that couple these two fundamental cellular activities are members of the inhibitor of apoptosis (IAP) protein family. In addition to their well-studied ability...

journal_title：IUBMB life

authors： Ni T,Li W,Zou F

更新日期：2005-12-01 00:00:00

abstract：:The members of the GATA family of transcription factors have homologous zinc fingers and bind to similar sequence motifs. Recent advances in genome-wide technologies and the integration of bioinformatics data have led to a better understanding of how GATA factors regulate gene expression; GATA-factor-induced transcrip...

journal_title：IUBMB life

authors： Romano O,Miccio A

更新日期：2020-01-01 00:00:00