Abstract:
:Heart disease is the most common cause of morbidity and mortality in Western society and the incidence is projected to increase significantly over the next few decades as our population ages. Heart failure occurs when the heart is unable to pump blood at a rate to commensurate with tissue metabolic requirements and represents the end stage of a variety of pathological conditions. Causes of heart failure include ischemia, hypertension, coronary artery disease, and idiopathic dilated cardiomyopathy. Hypertension and ischemia both cause infarction with loss of function and a consequent contractile deficit that promotes ventricular remodeling. Remodeling results in dramatic alterations in the size, shape, and composition of the walls and chambers of the heart and can have both positive and negative effects on function. In 30-40% of patients with heart failure, left ventricular systolic function is relatively unaffected while diastolic dysfunction predominates. Recent progress in our understanding of the molecular and cellular bases of heart disease has provided new therapeutic targets and led to novel approaches including the delivery of proteins, genes, and cells to replace defective or deficient components and restore function to the diseased heart. This review focuses on three such strategies that are currently under development: (a) gene transfer to modulate contractility, (b) therapeutic angiogenesis for the treatment of ischemia, and (c) embryonic and adult stem cell transfer to replace damaged myocardium.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Graham RM,Bishopric NH,Webster KAdoi
10.1080/15216540214312keywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
59-66issue
2eissn
1521-6543issn
1521-6551journal_volume
54pub_type
杂志文章,评审相关文献
IUBMB LIFE文献大全abstract::The reaction between nitric oxide ((.)NO) and oxygen yields reactive species capable of oxidizing and nitrosating proteins, as well as deaminating DNA bases. Although this reaction is considered too slow to be biologically relevant, it has been shown that membranes, lipoproteins, mitochondria and possibly proteins can...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540701311147
更新日期:2007-04-01 00:00:00
abstract::The acidic phospholipase A2 isoform from the spitting cobra Naja mossambica mossambica is activated irreversibly by treatment with a molar equivalent of oleoyl imidazolide. The kinetics of the chemical modification of the enzyme can also be monitored by measuring the large reduction of tryptophan fluorescence, which i...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803513
更新日期:1999-09-01 00:00:00
abstract::Availability of the human genome data has enabled the exploration of a huge amount of biological information encoded in it. There are extensive ongoing experimental efforts to understand the biological functions of the gene products encoded in the human genome. However, computational analysis can aid immensely in the ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540400006105
更新日期:2004-06-01 00:00:00
abstract::Hydrogen peroxide is a major regulator of plant programmed cell death (PCD) but little is known about the downstream genes from the H(2)O(2)-signaling network that mediate the cell death. To address this question, a novel system for studying H(2)O(2)-induced programmed cell death in Arabidopsis thaliana was used. The ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540500090793
更新日期:2005-03-01 00:00:00
abstract::The conformational stability of the homotetrameric Plasmodium falciparum beta-ketoacyl-ACP reductase (FabG) was determined by guanidinium chloride-induced isothermal and thermal denaturation. The reversible unfolding transitions were monitored by intrinsic fluorescence, circular dichroism (CD) spectroscopy and by meas...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540701472113
更新日期:2007-07-01 00:00:00
abstract::Synucleinopathies are neurodegenerative diseases characterized by the accumulation of either neuronal/axonal or glial insoluble proteinaceous aggregates mainly composed of α-synuclein (α-syn). Among them, the most common disorders are Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and some fo...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2194
更新日期:2020-04-01 00:00:00
abstract::The current landscapes of novel therapeutic approaches rely mostly on gene-targeted technologies, enabling to fight rare genomic diseases, from infections to cancer and hereditary diseases. Although, reaching the action-site for this novel treatments requires to deliver nucleic acids, or other macromolecules into cell...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1257
更新日期:2014-03-01 00:00:00
abstract::The immunosuppressant cyclosporin A (CsA)-sensitive nuclear factor of activated T cells 1 (NFAT1) has been known to be a transcriptional regulator of cytokine and viral genes during the immune response. By analyses of serial deletion, mutation, and heterologous promoter assay, we report here that the CsA-sensitive NFA...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/152165401753311807
更新日期:2001-04-01 00:00:00
abstract::Transketolase (TK) is a homodimer, the simplest representative of thiamine diphosphate (ThDP)-dependent enzymes. It was first ThDP-dependent enzymes the crystal structure of which has been solved and revealed the general fold for this class of enzymes and the interactions of the non-covalently bound coenzyme ThDP with...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540500167203
更新日期:2005-07-01 00:00:00
abstract::Prostate cancer (PCa) is considered the most common malignancy in men. The aim of this study is to assess the role of serum miR-15a and miR-16-1 expression in PCa development, diagnosis and prognosis aiming to find a specific noninvasive biomarker. This study comprised 70 patients with PCa, 70 patients complaining of ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1733
更新日期:2018-05-01 00:00:00
abstract::We have adapted the Java Molecular Viewer (JMV) to virtual reality display environments, through a number of extensions to the Java 3D code. Phylogenetic information derived from multiple alignments (temporal information) can be overlaid onto molecule structures (spatial information). The number of sequences included ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/1521654031000136255
更新日期:2003-04-01 00:00:00
abstract::The invasion and chemoresistance are crucial causes of morbidity and relapse for cancer patients. Axl is implicated in the modulation of cell invasion, cancer metastasis, and chemosensitivity in human breast carcinoma cell lines. Both breast cancer cell lines and tissues displayed increased expression of Axl, and it o...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1285
更新日期:2014-07-01 00:00:00
abstract::In this article, the experiments used to construct the ambient pH-signaling network involved in the secretion of enzymes by filamentous fungi have been reviewed, focusing on the phosphate-repressible phosphatases in Aspergillus nidulans. Classic and molecular genetics have been used to demonstrate that proteolysis of ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1217
更新日期:2013-11-01 00:00:00
abstract::Myocardial ischemia/reperfusion (I/R) injury greatly contributes to myocardial tissue damage in patients with coronary disease, which eventually leads to heart failure. Long noncoding RNAs (lncRNAs) have an emerging role in the process of myocardial I/R injury. Our previous work revealed the protective role of miR-374...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2428
更新日期:2020-12-09 00:00:00
abstract::The sodA gene coding for manganese superoxide dismutase (Mn-SOD) from the marine microorganism Vibrio parahaemolyticus was cloned, sequenced, and overexpressed in Escherichia coli by use of the pET20b (+) expression vector. The full-length gene consisted of a 588-bp open reading frame and encoded a polypeptide of 196 ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803521
更新日期:1999-09-01 00:00:00
abstract::Reactive oxygen and nitrogen species (ROS and RNS) have been extensively recognized as important signaling molecules implicated in physiological processes such as gene expression, cell differentiation and immune activation. Nevertheless, continuous production of these species may produce oxidative and/or nitrosative s...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540310001628717
更新日期:2003-10-01 00:00:00
abstract::Women with breast cancer show altered blood glucose compartmentation compared with healthy women, with lower concentrations in plasma and similar concentrations in blood cells. The goal of this paper was to study whether this pattern was the result of changes in the erythrocyte glucose transporter and, if so, to asses...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803558
更新日期:1999-11-01 00:00:00
abstract::The existence of a genetic component in mycobacterial disease susceptibility is no longer in doubt and the investigations now being conducted aim to determine which genes are involved, to what extent, and in which disease phenotype they are relevant. In certain rare instances of susceptibility to poorly pathogenic myc...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540212644
更新日期:2002-04-01 00:00:00
abstract::Altered activity of the proteolytic machine-the 26S proteasome is observed in many disease conditions. Hence, either inhibition or activation of the 26S proteasome is thought to be a novel therapy for treatment of certain diseases such as cancer and neurodegenerative disorders. In this study, we tested the potential o...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1735
更新日期:2018-05-01 00:00:00
abstract::Traumatic optic neuropathy is an important cause of severe vision loss. So, many attempts were performed to transplant stem cells systemically or locally to regenerate the injured retina. In this study, we investigated the effect of human umbilical cord blood mesenchymal stem cells (hUBMSCs) on histological structure,...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1608
更新日期:2017-03-01 00:00:00
abstract::Papillary thyroid cancer (PTC) is the most common form of thyroid cancer, comprising 80% of all thyroid malignancies. The phosphoinositide-3-kinase-protein kinase B/Akt (PI3K-PKB/Akt) pathway is a main pathway in control of cell growth. Activated mTOR and Akt are involved in the development and progression of the PTC....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2388
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:Heart diseases are common in the offspring of gestational diabetic mother (ODM). Defects in mitochondrial metabolism and autophagy may, in part, be responsible for the adverse structural and functional alterations in the heart. The principal objective of this study was to investigate cardiac mitochondrial res...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2449
更新日期:2021-01-22 00:00:00
abstract::Retinitis pigmentosa comprises a large and exceptionally heterogeneous group of hereditary disorders of the retina. As a result of an extensive investigation around the world, primary genetic lesions have been described in many genes. Some of these genes encode enzymes that are involved in the signal transduction path...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540050167007
更新日期:2000-06-01 00:00:00
abstract::Recently the crystal structure of creatine kinase from Torpedocalifornica was determined to 2.1 A. The dimeric structure revealed two different forms in the unit cell: one monomer was bound to a substrate, MgADP, and the other monomer was bound to a transition-state analogue complex composed of MgADP, nitrate and crea...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540500091999
更新日期:2005-04-01 00:00:00
abstract::The functional effect of the interaction of E2F1 and hepatitis B virus X protein (HBx) on the promoter of human p53 gene was studied using chloramphenicol acetyl transferase (CAT) assay. E2F1 activated the p53 promoter through E2F1 binding site. As previously reported, HBx repressed the p53 promoter through E-box. Whe...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540213466
更新日期:2002-06-01 00:00:00
abstract::Recent successes in identifying the genes and associated proteins underlying several familial neurodegenerative conditions have not always resulted in accounts as to why the associated patterns of neuronal damage are so specific and limited. Here, with reference to Huntington's disease, we present a general scheme to ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/1521654031000153012
更新日期:2003-06-01 00:00:00
abstract::Cell-surface-bound extracellular DNA (csbDNA) is present on the outer membrane of blood cells, including both red blood cells and leukocytes. Although less well characterized than cell-free DNA (cfDNA) in plasma and serum, leukocyte and red blood cell csbDNA form a considerable fraction of the blood extracellular nucl...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2070
更新日期:2019-09-01 00:00:00
abstract::Anthracyclines are a class of antitumor drugs widely used for the treatment of a variety of malignancy, including leukemias, lymphomas, sarcomas, and carcinomas. Different mechanisms have been proposed for anthracycline antitumor effects including free-radical generation, DNA intercalation/binding, activation of signa...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540252774829
更新日期:2001-07-01 00:00:00
abstract::Magnetic targeting has shown promise to improve the efficacy and safety of different classes of therapeutic agents by enabling their active guidance to the site of disease and minimizing dissemination to nontarget tissues. However, its translation into clinic has proven difficult because of inherent limitations of tra...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.479
更新日期:2011-08-01 00:00:00
abstract::Cancer related inflammation (CRI) is now recognized as the seventh hallmark in the pathogenesis of many types of malignancies. Paeonol, a natural phenolic component isolated from the root bark of Paeonia moutan, has significant anti-inflammatory activity. Recently, accumulating body of research has revealed potent ant...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1435
更新日期:2015-10-01 00:00:00