Abstract：
:In this article, the experiments used to construct the ambient pH-signaling network involved in the secretion of enzymes by filamentous fungi have been reviewed, focusing on the phosphate-repressible phosphatases in Aspergillus nidulans. Classic and molecular genetics have been used to demonstrate that proteolysis of the transcription factor PacC at alkaline ambient pH is imperative for its action, implying that the full-length version is not an active molecular form of PacC. It has been hypothesized that the transcriptional regulator PacC may be functional at both acidic and alkaline ambient pH, in either the full-length or the proteolyzed form, if it carries a pal-dependent molecular tag. The products of the pal genes are involved in a metabolic pathway that led to the synthesis of effector molecules that tag the pacC product, perhaps facilitating its proteolysis.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Rossi A,Cruz AH,Santos RS,Silva PM,Silva EM,Mendes NS,Martinez-Rossi NMdoi
10.1002/iub.1217subject
Has Abstractpub_date
2013-11-01 00:00:00pages
930-5issue
11eissn
1521-6543issn
1521-6551journal_volume
65pub_type
杂志文章相关文献
IUBMB LIFE文献大全abstract：:In the present study we demonstrated Jurkat leukemia cell lines of TIB152 and TIB153 with different sensitivities to recombinant soluble TRAIL cytotoxicity. TRAIL receptor death receptor 5 (DR5) was constitutively localized in the rafts in both cell lines. FADD, caspase-8, and PI3K-p85 subunit were recruited into DR5 ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.166
更新日期：2009-03-01 00:00:00
abstract：:The ATP-sensitive potassium (K(ATP)) channel is expressed in most excitable tissues and plays a critical role in numerous physiological processes by coupling intracellular energetics to electrical activity. The channel is comprised of four Kir6.x subunits associated with four regulatory sulfonylurea receptors (SUR). I...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.246
更新日期：2009-10-01 00:00:00
abstract：:Insulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase Akt/mammalian target of rapamycin (mTOR), Ras/Raf/extracellular signal-regulated kinase (ERK), and phosph...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.1172
更新日期：2013-07-01 00:00:00
abstract：:The immunosuppressant cyclosporin A (CsA)-sensitive nuclear factor of activated T cells 1 (NFAT1) has been known to be a transcriptional regulator of cytokine and viral genes during the immune response. By analyses of serial deletion, mutation, and heterologous promoter assay, we report here that the CsA-sensitive NFA...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/152165401753311807
更新日期：2001-04-01 00:00:00
abstract：:Human ecto-ATPase (ecto-nucleoside triphosphate diphosphohydrolase 2 [eNTPDase2], also known as CD39L1) has been expressed and characterized in COS cells. It exhibits some unusual enzymology that is similar to a few members of this class of proteins but different from the majority of the family members. Hydrolysis of ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/15216540050176584
更新日期：2000-07-01 00:00:00
abstract：:The posttranscriptional regulation of miRNAs is important for organism development. To investigate the role of miRNAs in angiogenesis, we performed a loss-of-function screening assay in human umbilical vein endothelial cells (HUVECs) and found that knockdown of 7 miRNAs (miR-95a, miR-126, miR-129, miR-137, miR-139, mi...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.486
更新日期：2011-07-01 00:00:00
abstract：:The activation and incorporation of selenium into selenocysteine containing selenoproteins has been well established in an Escherichia coli model system but there is little specific information concerning the transport and intracellular trafficking of selenium in biological systems in general. A selenium transport rol...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/15216540400010818
更新日期：2004-08-01 00:00:00
abstract：:Tetrameric haemoglobins display a cooperative ligand binding behaviour, which has been attributed to the functional interrelationship between multiple ligand binding sites. The quantitative description of this feature was initially carried out with a phenomenological approach, which was limited to the functional effec...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.6
更新日期：2008-02-01 00:00:00
abstract：:In this review we discuss the limited efficacy for current pharmacological agents used in prophylaxis and treatment of thrombosis and highlight targeted delivery of anti-thrombotic agents to fibrin, platelets, red blood cells and endothelium. ...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.474
更新日期：2011-08-01 00:00:00
abstract：:Arginine biosynthesis pathway is crucial to the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). Arginine is a critical amino acid that contributes to the inflection of cellular immune responses during pathogenesis. Argininosuccinate lyase from Mtb (MtArgH), the last enzyme in the pathway, catalyzes the ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1683
更新日期：2017-11-01 00:00:00
abstract：:Ten-eleven translocation (TET) family enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine in DNA. However, the role of TET enzymes in human gastric cancer remains unknown. Here, we show that TET2 mRNA and protein levels are downregulated in human gastric cancer tissues when compared with normal gastric mucosa....
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1490
更新日期：2016-05-01 00:00:00
abstract：:Cardiac hypoxia plays a significant role in various types of heart disease, and improper treatment of hypoxia often leads to myocardial cell damage or even death. Transcriptome profiling and open chromatin mapping have been used as powerful tools to understand the development of heart disease, but the interplay betwee...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.2297
更新日期：2020-08-01 00:00:00
abstract：:PlncRNA-1 has been suggested to function as an oncogenic role in prostate cancer, colorectal cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma, and gastric cancer. The expression pattern of PlncRNA-1 in retinoblastoma remained unknown. Therefore, the aim of this study was to explore the clinical sig...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1886
更新日期：2018-10-01 00:00:00
abstract：:Release of arachidonic acid from membrane glycerophospholipids by cytosolic phospholipase A2 (cPLA2) is a key step in the generation of platelet-activating factor (PAF), recognized as the most proximal mediator of inflammatory events triggered by bacterial infection. Here, we report on the role of cPLA2 in the disturb...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/15216540600732021
更新日期：2006-04-01 00:00:00
abstract：:The members of the GATA family of transcription factors have homologous zinc fingers and bind to similar sequence motifs. Recent advances in genome-wide technologies and the integration of bioinformatics data have led to a better understanding of how GATA factors regulate gene expression; GATA-factor-induced transcrip...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.2169
更新日期：2020-01-01 00:00:00
abstract：:Interferon regulatory factors (IRFs) were originally discovered in the context of type I interferon (IFN-alpha/beta) gene induction, and subsequent studies on these transcription factors have revealed their remarkable functional diversity in regulating immune systems. Indeed, the critical involvement of IRF members in...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540600702206
更新日期：2006-05-01 00:00:00
abstract：:Extracellular matrix (ECM)-independent survival is an essential prerequisite for tumor metastasis, and a hallmark of epithelial cancer stem cells and epithelial-mesenchymal transition (EMT). Here, we found that loss of TP53I11 enhanced, and overexpression of TP53I11 suppressed the ECM-independent survival, EMT, and mi...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1949
更新日期：2019-02-01 00:00:00
abstract：:Retinitis pigmentosa comprises a large and exceptionally heterogeneous group of hereditary disorders of the retina. As a result of an extensive investigation around the world, primary genetic lesions have been described in many genes. Some of these genes encode enzymes that are involved in the signal transduction path...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540050167007
更新日期：2000-06-01 00:00:00
abstract：:Tilorone hydrochloride, a low-molecular-weight synthetic compound, induces interferon production and has been reported to have both antiviral and antitumor activities. Here, we have demonstrated the ability of tilorone to activate NK cells and specific subpopulations of cytotoxic CD4+ and CD8+ T lymphocytes that recog...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1985
更新日期：2019-03-01 00:00:00
abstract：:In this study, we intended to determine the detailed function and mechanism of long noncoding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) in liver injury induced by sepsis. Cecal ligation and perforation (CLP) models were adopted to induce sepsis in vivo with rats, and hepatic epithelial cells L...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.2230
更新日期：2020-03-01 00:00:00
abstract：:Heat shock proteins (Hsps) are a highly conserved family of proteins. The regulation of expression of Hsps in Mycobacterium tuberculosis, is regulated both positively and negatively by alternate sigma factors and transcriptional DNA repressors, respectively. HspR is a negative regulator of expression of hsps, DnaK, Cl...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1438
更新日期：2015-11-01 00:00:00
abstract：:Although the amino acid sequences and the structures of pyruvate kinase (PYK) isozymes are highly conserved, allosteric regulations differ. This suggests that amino acids with low conservation play important roles in the allosteric mechanism. The current work exploits a 'natural screen'- the 122 point mutations identi...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/15216540500531705
更新日期：2006-01-01 00:00:00
abstract：:The 10th jubilee conference (IPK2019) took place on September 15-19, 2019 in Warsaw, on the Ochota campus as the IUBMB Focused Meeting entitled "Inhibitors of Protein Kinases. Kinase inhibitors in target biology and disease". ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.2303
更新日期：2020-06-01 00:00:00
abstract：:The disappointing results from large clinical studies of α-tocopherol (αT), the major form of vitamin E in tissues, for prevention of chronic diseases including cancer have cast doubt on not only αT but also other forms of vitamin E regarding their role in preventing carcinogenesis. However, basic research has shown t...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.1978
更新日期：2019-04-01 00:00:00
abstract：:Mitochondria play a key role in death signaling. The intermembrane space of these organelles contains a number of proteins which promote cell death once they are redistributed to the cytosol. The formation of pores in the outer membrane of mitochondria defines a gateway through which the apoptogenic proteins pass duri...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.44
更新日期：2008-06-01 00:00:00
abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) is linked to the etiopathogenesis of Kaposi's sarcoma, a plasma-blastic variant of Castleman's disease and primary effusion lymphoma. KSHV is related to a number of non-human primate viruses. Only a limited number of KSHV proteins are expressed in tumor cells. He...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540050022395
更新日期：2000-02-01 00:00:00
abstract：:The functional effect of the interaction of E2F1 and hepatitis B virus X protein (HBx) on the promoter of human p53 gene was studied using chloramphenicol acetyl transferase (CAT) assay. E2F1 activated the p53 promoter through E2F1 binding site. As previously reported, HBx repressed the p53 promoter through E-box. Whe...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/15216540213466
更新日期：2002-06-01 00:00:00
abstract：:The beta/alpha-barrel motif was once considered to be a single protein domain. In recent years, however, it has been shown to consist of smaller substructures displaying the ability to fold autonomously. Here we review the current status of experimental findings concerning the motif's folding behavior in the light of ...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540214924
更新日期：2002-10-01 00:00:00
abstract：:Depurinating DNA adducts formed by aromatic hydrocarbons and catechol estrogen quinones play a major role in cancer initiation. Most of these adducts depurinate instantaneously, but some guanine adducts depurinate from DNA with half-lives of hours. We report here, that after 10 h at 37 °C, reaction of estradiol-3,4-qu...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.586
更新日期：2012-02-01 00:00:00
abstract：:Traumatic optic neuropathy is an important cause of severe vision loss. So, many attempts were performed to transplant stem cells systemically or locally to regenerate the injured retina. In this study, we investigated the effect of human umbilical cord blood mesenchymal stem cells (hUBMSCs) on histological structure,...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1608
更新日期：2017-03-01 00:00:00
