IUBMB focused meeting: 10th conference Inhibitors of Protein Kinases. Kinase inhibitors in target biology and disease (IPK2019).

abstract：:Endothelial dysfunction is fundamental to ischemic stroke and brain injury. The humanin analogue S14G-humanin (HNG) has been shown to be a cytoprotective derivative. In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro. In a murine middle cerebral artery occlusion (MCAO) stroke model,...

journal_title：IUBMB life

authors： Peng T,Wan W,Wang J,Liu Y,Fu Z,Ma X,Li J,Sun G,Ji Y,Lu J,Lu H,Liu Y

更新日期：2018-07-01 00:00:00

abstract：:The faithful propagation of cellular signals in most organisms relies on the coordinated functions of a large family of protein kinases that share a conserved catalytic domain. The catalytic domain is a dynamic scaffold that undergoes large conformational changes upon activation. Most of these conformational changes, ...

journal_title：IUBMB life

authors： Yeung W,Ruan Z,Kannan N

更新日期：2020-06-01 00:00:00

abstract：:The functional effect of the interaction of E2F1 and hepatitis B virus X protein (HBx) on the promoter of human p53 gene was studied using chloramphenicol acetyl transferase (CAT) assay. E2F1 activated the p53 promoter through E2F1 binding site. As previously reported, HBx repressed the p53 promoter through E-box. Whe...

journal_title：IUBMB life

authors： Choi M,Lee H,Rho HM

更新日期：2002-06-01 00:00:00

abstract：:Cisplatin (CP), as a chemotherapeutic drug, causes nephrotoxicity that has limited the clinical utility of CP. Gliclazide (GLZ), as an antihyperglycemic drug, at low dose has antioxidant property. In this study, we aimed to investigate the protective effect of GLZ against CP-induced acute renal injury. Sixty-four BALB...

journal_title：IUBMB life

authors： Taghizadeh F,Hosseinimehr SJ,Zargari M,Karimpour Malekshah A,Talebpour Amiri FB

更新日期：2020-09-01 00:00:00

abstract：:Sirolimus(SRL, Rapamune(â), rapamycin) is a highly specific inhibitor of mammalian target of rapamycin (mTOR). Sirolimus exerts its biological activity by inhibiting the serine-threonine kinase mammalian target of rapamycin (mTOR), which regulates important cellular processes such as control of cell cycle, cell size, ...

journal_title：IUBMB life

authors： Wang Y,Zhao Q,Ma S,Yang F,Gong Y,Ke C

更新日期：2007-11-01 00:00:00

abstract：:Deletion of tumor suppressor gene, lethal(2)giant larvae [l(2)gl], leads to brain tumor in Drosophila melanogaster at larval stage of development and severe brain dysplasia in mice. We have studied the effect of two potential antitumor drugs artemisinin and curcumin in the perspective of inhibiting l(2)gl brain tumor....

journal_title：IUBMB life

authors： Das SS,Nanda GG,Alone DP

更新日期：2014-07-01 00:00:00

abstract：:Various strategies have been applied to replace the loss of cardiomyocytes in order to restore reduced cardiac function and prevent the progression of heart disease. Intensive research efforts in the field of cellular reprogramming and cell transplantation may eventually lead to efficient in vivo applications for the ...

journal_title：IUBMB life

authors： Välimäki MJ,Ruskoaho HJ

更新日期：2020-01-01 00:00:00

abstract：:Elevated homocysteine levels are known to be a risk factor for congenital cardiac septal defects (CCSDs), but the mechanism underlying this effect is unknown. The genetic variants that were significantly associated with circulating homocysteine concentrations have been systematically identified through the genome-wide...

journal_title：IUBMB life

authors： Xie HH,Li J,Li PQ,Zhang AA,Li Y,Wang YZ,Xie DX,Xie XD

更新日期：2017-09-01 00:00:00

abstract：:Renal ischemia/reperfusion (I/R) is an alternation of renal hemodynamics, which results in diverse postischemic responses and eventually acute kidney injury. Although renal ischemic preconditioning (IPC) is known to protect the kidney from I/R injury, the precise renoprotective mechanisms are not completely understood...

journal_title：IUBMB life

authors： Li JR,Ou YC,Wu CC,Wang JD,Lin SY,Wang YY,Chen WY,Chen CJ

更新日期：2019-03-01 00:00:00

abstract：:Cooperative effects in ligand binding and dissociation kinetics are much less investigated than steady state kinetics or equilibrium binding. Nevertheless, cooperativity in ligand binding leads necessarily to characteristic properties with respect to kinetic properties of the system. In case of positive cooperativity ...

journal_title：IUBMB life

authors： Hellmann N

更新日期：2011-05-01 00:00:00

abstract：:The rat organic anion transporter 3 (rOAT3) has recently been identified as the third isoform of the OAT family. The mechanisms that regulate rOAT3's functions remain to be elucidated. rOAT3 contributes for moving a number of negatively charged organic compounds between cells and their extracellular milieu. Caveolin (...

journal_title：IUBMB life

authors： Kwak JO,Kim HW,Song JH,Kim MJ,Park HS,Hyun DK,Kim DS,Cha SH

更新日期：2005-02-01 00:00:00

abstract：:Modern cell-free in vitro protein synthesis systems present powerful tools for the synthesis of isotope-labeled proteins in high yields. The production of selectively 15 N-labeled proteins from 15 N-labeled amino acids is particularly economic and yields are often sufficient to analyze the proteins very quickly by two...

journal_title：IUBMB life

authors： Ozawa K,Dixon NE,Otting G

更新日期：2005-09-01 00:00:00

abstract：:The yeast Saccharomyces cerevisiae is an excellent model for gaining insights into the molecular basis of human mitochondrial disorders, particularly those resulting from impaired mitochondrial metabolism. Yeast is a very well characterized system and most of our current knowledge about mitochondrial biogenesis in hum...

journal_title：IUBMB life

authors： Barrientos A

更新日期：2003-02-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a lethal malignancy and its prognosis remains dismal. Thus, a deeper understanding of the mechanisms is needed to provide a new insight for new therapies. It has been reported that long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) was downregulated in OSCC tissues, h...

journal_title：IUBMB life

authors： Tan J,Xiang L,Xu G

更新日期：2019-07-01 00:00:00

abstract：:To further understand the role of the three conserved Val residues in insulin, B12Val, B18Val, and A3Val, five insulin mutants-[A3Ser]insulin, [B12Thr]insulin, (desB30)[B12Ser]insulin, [B18Thr] insulin, and [B18Leu]insulin--were obtained by means of site-directed mutagenesis and their receptor-binding activities as we...

journal_title：IUBMB life

authors： Guo ZY,Tang YH,Zhang Z,Feng YM

更新日期：2001-12-01 00:00:00

abstract：:Cell-surface-bound extracellular DNA (csbDNA) is present on the outer membrane of blood cells, including both red blood cells and leukocytes. Although less well characterized than cell-free DNA (cfDNA) in plasma and serum, leukocyte and red blood cell csbDNA form a considerable fraction of the blood extracellular nucl...

journal_title：IUBMB life

authors： Tamkovich S,Laktionov P

更新日期：2019-09-01 00:00:00

abstract：:Toll-like receptors (TLRs) are a subset of pattern recognition receptors (PRR) in innate immunity and act as a connecting link between innate and adaptive immune systems. During Leishmania infection, the activation of TLRs influences the pathogen-specific immune responses, which may play a decisive role in determining...

journal_title：IUBMB life

authors： Jafarzadeh A,Nemati M,Sharifi I,Nair A,Shukla D,Chauhan P,Khorramdelazad H,Sarkar A,Saha B

更新日期：2019-11-01 00:00:00

abstract：:Interplay between the apoptosis, DNA damage, and oxidative stress as a host response to dengue viral infections remains unclear. Peripheral blood mononuclear cells (PBMCs) were isolated from 60 dengue infected patients, 20 patients with febrile illness other than dengue (OFI) and 10 non-febrile illness (NFI) patients....

journal_title：IUBMB life

authors： Cherupanakkal C,Samadanam DM,Muthuraman KR,Ramesh S,Venkatesan A,Balakrishna Pillai AK,Rajendiran S

更新日期：2018-11-01 00:00:00

abstract：:In protein and RNA macromolecules, only a limited number of different side-chain chemical groups are available to function as catalysts. The myriad of enzyme-catalyzed reactions results from the ability of most of these groups to function either as nucleophilic, electrophilic, or general acid-base catalysts, and the k...

journal_title：IUBMB life

authors： Harris TK,Turner GJ

更新日期：2002-02-01 00:00:00

abstract：:This study was expected to reveal the regulatory effects of lncRNA UCA1 on pancreatic cancer cell progression through targeting miR-96/FOXO3. Microarray analysis was carried out on 36 cases of pancreatic cancer tissues and 16 cases of adjacent tissues among them. Expression levels of lncRNA UCA1, miR-96, and FOXO3 in ...

journal_title：IUBMB life

authors： Zhou Y,Chen Y,Ding W,Hua Z,Wang L,Zhu Y,Qian H,Dai T

更新日期：2018-04-01 00:00:00

abstract：:The mitochondrial ATP-Mg/Pi carrier is responsible for the calcium-dependent regulation of adenosine nucleotide concentrations in the mitochondrial matrix, which allows mitochondria to respond to changing energy requirements of the cell. The carrier is expressed in mitochondria of fungi, plants and animals and belongs...

journal_title：IUBMB life

authors： Harborne SPD,Kunji ERS

更新日期：2018-12-01 00:00:00

abstract：:Mutations in the breast cancer susceptibility gene BRCA1 predispose individuals to breast and ovarian cancers. Cofactor of BRCA1 (COBRA1), a novel protein, was isolated as a BRCA1-interacting protein. However, the role of COBRA1 in breast cancer is poorly understood. In this study, we demonstrate that COBRA1 mRNA was ...

journal_title：IUBMB life

authors： Zhu J,Song S,Jiang Z,Yan J,Lu Q,Huang C,Ye Q

更新日期：2004-03-01 00:00:00

abstract：:Diarrhea-predominant irritable bowel syndrome (IBS-D) is one of the most common gastrointestinal disorders in the world, lacking effective therapies. The crucial roles of microRNAs (miRNAs) in IBS-D have attracted increasing attention. The aim of this study is to investigate the effects of miR-495 on the visceral sens...

journal_title：IUBMB life

authors： Fei L,Wang Y

更新日期：2020-07-01 00:00:00

abstract：:Shiga toxin (Stx) producing Escherichia coli (STEC) is responsible to bloody diarrhea (hemorrhagic colitis) and the hemolytic uremic syndrome (HUS). STEC strains carry inducible lambda phages integrated into their genomes that encode Stx 1 and/or 2, with several allelic variants each one. O157:H7 is the serotype that ...

journal_title：IUBMB life

authors： Ibarra C,Amaral MM,Palermo MS

更新日期：2013-10-01 00:00:00

abstract：:The extensive post-transcriptional modification of U2 snRNA is required for spliceosome assembly and pre-mRNA splicing in vertebrates. However, the rare modification of U2 snRNA in yeast implies a different mechanism for regulating spliceosome biogenesis in single-celled eukaryotes. To understand the evolutionary patt...

journal_title：IUBMB life

authors： Huang ZP,Zhou H,Qu LH

更新日期：2005-10-01 00:00:00

abstract：:Over the past decade, following the discovery of the human heme protein neuroglobin, many studies have searched for evidence for this protein's mechanism of action. Much data has accrued showing that high levels of neuroglobin will protect cells from apoptotic cell death, following a wide range of challenges. Various ...

journal_title：IUBMB life

authors： Brittain T,Skommer J,Henty K,Birch N,Raychaudhuri S

更新日期：2010-12-01 00:00:00

abstract：:Immune infiltration of tumors has been increasingly accepted as a prognostic factor in colon cancer. Here, we aim to develop a novel immune signature, based on estimated immune landscape from tumor transcriptomes, to predict the overall survival of patients with colon cancer. The compositions of 22 immune cell subtype...

journal_title：IUBMB life

authors： Peng D,Wang L,Li H,Cai C,Tan Y,Xu B,Le H

更新日期：2019-11-01 00:00:00

abstract：:We investigated signaling pathways leading to tumor necrosis factor (TNF) alpha-induced intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 expression in chondrosarcoma cells, and determined the functional significance of their expression by examining Jurkat T cell adhesion. TNFalpha ...

journal_title：IUBMB life

authors： Ju JW,Kim SJ,Jun CD,Chun JS

更新日期：2002-11-01 00:00:00

abstract：:Vibrio cholerae is the causative agent of the diarrheal disease cholera, for which biofilm communities are considered to be environmental reservoirs. In endemic regions, and after algal blooms, which may result from phosphate enrichment following agricultural runoff, the bacterium is released from biofilms resulting i...

journal_title：IUBMB life

authors： Maestre-Reyna M,Huang WC,Wu WJ,Singh PK,Hartmann R,Wang PH,Lee CC,Hikima T,Yamamoto M,Bessho Y,Drescher K,Tsai MD,Wang AH

更新日期：2021-02-01 00:00:00

abstract：:Myocardial ischemia/reperfusion (I/R) injury greatly contributes to myocardial tissue damage in patients with coronary disease, which eventually leads to heart failure. Long noncoding RNAs (lncRNAs) have an emerging role in the process of myocardial I/R injury. Our previous work revealed the protective role of miR-374...

journal_title：IUBMB life

authors： Chen YQ,Yang X,Xu W,Yan Y,Chen XM,Huang ZQ

更新日期：2020-12-09 00:00:00