Abstract:
:The disappointing results from large clinical studies of α-tocopherol (αT), the major form of vitamin E in tissues, for prevention of chronic diseases including cancer have cast doubt on not only αT but also other forms of vitamin E regarding their role in preventing carcinogenesis. However, basic research has shown that specific forms of vitamin E such as γ-tocopherol (γT), δ-tocopherol (δT), γ-tocotrienol (γTE) and δ-tocotrienol (δTE) can inhibit the growth and induce death of many types of cancer cells, and are capable of suppressing cancer development in preclinical cancer models. For these activities, these vitamin E forms are much stronger than αT. Further, recent research revealed novel anti-inflammatory and anticancer effects of vitamin E metabolites including 13'-carboxychromanols. This review focuses on anti-proliferation and induction of death in cancer cells by vitamin E forms and metabolites, and discuss mechanisms underlying these anticancer activities. The existing in vitro and in vivo evidence indicates that γT, δT, tocotrienols and 13'-carboxychromanols have anti-cancer activities via modulating key signaling or mediators that regulate cell death and tumor progression, such as eicosanoids, NF-κB, STAT3, PI3K, and sphingolipid metabolism. These results provide useful scientific rationales and mechanistic understanding for further translation of basic discoveries to the clinic with respect to potential use of these vitamin E forms and metabolites for cancer prevention and therapy. © 2018 IUBMB Life, 71(4):495-506, 2019.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Jiang Qdoi
10.1002/iub.1978subject
Has Abstractpub_date
2019-04-01 00:00:00pages
495-506issue
4eissn
1521-6543issn
1521-6551journal_volume
71pub_type
杂志文章,评审相关文献
IUBMB LIFE文献大全abstract::Recent successes in identifying the genes and associated proteins underlying several familial neurodegenerative conditions have not always resulted in accounts as to why the associated patterns of neuronal damage are so specific and limited. Here, with reference to Huntington's disease, we present a general scheme to ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/1521654031000153012
更新日期:2003-06-01 00:00:00
abstract::Bladder carcinoma is an important worldwide health problem. Both cystoscopy and urine cytology used in detecting bladder cancer suffer from drawbacks where cystoscopy is an invasive method and urine cytology shows low sensitivity in low-grade tumors. This study validates easier and less time-consuming techniques for t...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.325
更新日期:2010-05-01 00:00:00
abstract::Cardiovascular disease is a leading cause of morbidity and mortality. Smooth muscle cells (SMC) comprising the vascular wall can switch phenotypes from contractile to synthetic, which can promote the development of aberrant remodelling and intimal hyperplasia (IH). MicroRNA-21 (miR-21) is a short, non-coding RNA that ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1751
更新日期:2018-07-01 00:00:00
abstract::Calcium-sensing receptor (CaSR) contributes to maintain homeostatic levels of extracellular calcium. In addition, CaSR controls other cellular activities such as proliferation and migration, particularly in cells not related to extracellular calcium homeostasis, potentially by cross-talking with parallel signaling pat...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1232
更新日期:2013-12-01 00:00:00
abstract::Carbon monoxide (CO) is a gaseous transmitter that is known to be involved in several physiological processes, but surprisingly it is also becoming a promising molecule to treat several pathologies including stroke and cancer. CO can cross the plasma membrane and activate guanylate cyclase, increasing the cGMP concent...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1388
更新日期:2015-06-01 00:00:00
abstract::In the present study we demonstrated Jurkat leukemia cell lines of TIB152 and TIB153 with different sensitivities to recombinant soluble TRAIL cytotoxicity. TRAIL receptor death receptor 5 (DR5) was constitutively localized in the rafts in both cell lines. FADD, caspase-8, and PI3K-p85 subunit were recruited into DR5 ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.166
更新日期:2009-03-01 00:00:00
abstract::Tumstatin is a candidate tumor suppressor that plays an important role in tumor growth and angiogenesis. The purpose of this study was to evaluate the correlation between tumstatin-mRNA expression and the clinicopathologic characteristics, tumor angiogenesis, outcome of patients with non-small cell lung cancer (NSCLC)...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1016
更新日期:2012-05-01 00:00:00
abstract::Cocaine is a powerful central nervous stimulant and among the most abused of drugs. Despite decades of efforts, however, no effective pharmacological treatments are available against cocaine addiction or toxic effects. Classical receptor-antagonist therapeutic approaches have not yielded significant effects, although ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/1521654031000138541
更新日期:2003-07-01 00:00:00
abstract::Occlusion of a coronary artery if maintained for longer period of time results in damage of the cardiac tissue. However, restoration of blood flow to previously ischemic tissue can itself induce further cardiac damage, a phenomenon known as myocardial reperfusion injury. Cardiac homoeostasis is supported by a network ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1352
更新日期:2015-02-01 00:00:00
abstract::The members of the GATA family of transcription factors have homologous zinc fingers and bind to similar sequence motifs. Recent advances in genome-wide technologies and the integration of bioinformatics data have led to a better understanding of how GATA factors regulate gene expression; GATA-factor-induced transcrip...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2169
更新日期:2020-01-01 00:00:00
abstract::In tsRSV-infected NRK (tsNRK) cells, pp60(v-src) reactivation by temperature-shift from a nonpermissive temperature, 39 C, to a permissive one, 32 degrees C, induced the production of inositol phosphates (IPt) and phosphatidylethanol (PEt). This was accompanied by an increase in membrane-associated protein kinase C (P...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803467
更新日期:1999-07-01 00:00:00
abstract::Although vitamin E has been recognized as a critical micronutrient to neuronal health for more than half a century, vitamin E transport and regulation in the brain remain a mystery. Currently, the majority of what is known about vitamin E transport has been delineated in the liver. However, clues from the pathogenesis...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1993
更新日期:2019-04-01 00:00:00
abstract::Matrix metalloproteinase-9 (MMP-9) regulates remodeling of the left ventricle after myocardial infarction (MI) and is tightly linked to the inflammatory response. The inflammatory response serves to recruit leukocytes as part of the wound healing reaction to the MI injury, and infiltrated leukocytes produce cytokines ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1408
更新日期:2015-08-01 00:00:00
abstract::The acidic phospholipase A2 isoform from the spitting cobra Naja mossambica mossambica is activated irreversibly by treatment with a molar equivalent of oleoyl imidazolide. The kinetics of the chemical modification of the enzyme can also be monitored by measuring the large reduction of tryptophan fluorescence, which i...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803513
更新日期:1999-09-01 00:00:00
abstract::Shiga toxin (Stx) producing Escherichia coli (STEC) is responsible to bloody diarrhea (hemorrhagic colitis) and the hemolytic uremic syndrome (HUS). STEC strains carry inducible lambda phages integrated into their genomes that encode Stx 1 and/or 2, with several allelic variants each one. O157:H7 is the serotype that ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1206
更新日期:2013-10-01 00:00:00
abstract::The invasion and chemoresistance are crucial causes of morbidity and relapse for cancer patients. Axl is implicated in the modulation of cell invasion, cancer metastasis, and chemosensitivity in human breast carcinoma cell lines. Both breast cancer cell lines and tissues displayed increased expression of Axl, and it o...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1285
更新日期:2014-07-01 00:00:00
abstract::Role of nitric oxide (NO) on the expression of organic anion transporter 2 (OAT2) located in sinusoidal domain of hepatocytes has been investigated. Effect of NO generated in vivo in rat and delivered in vitro to hepatocytes was determined. Lipopolysaccharide (LPS) and spermine NONOate (SPER/NO) were selected as the N...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540214534
更新日期:2002-09-01 00:00:00
abstract::The pathophysiology of some inflammatory arterial diseases (such as vasculitis, atherogenesis and aneurysms) has been widely investigated in the last decades. Among different soluble molecules, proinflammatory cytokines (such as TNF-α, IL-1 and IL-6) were shown to trigger critical pathways regulating these arterial di...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1344
更新日期:2015-01-01 00:00:00
abstract::The best known NADPH oxidase is that of phagocytes-neutrophils and monocytes. In these cells, the enzyme manufactures large quantities of O2- and other reactive oxidants that are used for the purpose of killing invading microorganisms. Recent studies, however, have suggested that a number of other tissues contain NADP...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/713803730
更新日期:2000-10-01 00:00:00
abstract::Peroxynitrite is an inorganic toxin of physiological interest, formed from the diffusion-controlled reaction of superoxide and nitrogen monoxide with a rate constant of (1.6 +/- 0.3) x 10(10) M(-1) s(-1). On the basis of three experiments we conclude that homolysis of the O-O bond in peroxynitrous acid is unlikely: (1...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540310001628690
更新日期:2003-10-01 00:00:00
abstract::Hepatocyte mitochondrial aquaporin-8 (mtAQP8) works as a multifunctional membrane channel protein that facilitates the uptake of ammonia for its detoxification to urea as well as the mitochondrial release of hydrogen peroxide. Since early oligonucleotide microarray studies in liver of cholesterol-fed mice showed an AQ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1615
更新日期:2017-05-01 00:00:00
abstract::The mitochondrial ATP-Mg/Pi carrier is responsible for the calcium-dependent regulation of adenosine nucleotide concentrations in the mitochondrial matrix, which allows mitochondria to respond to changing energy requirements of the cell. The carrier is expressed in mitochondria of fungi, plants and animals and belongs...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1931
更新日期:2018-12-01 00:00:00
abstract::Interferon regulatory factors (IRFs) were originally discovered in the context of type I interferon (IFN-alpha/beta) gene induction, and subsequent studies on these transcription factors have revealed their remarkable functional diversity in regulating immune systems. Indeed, the critical involvement of IRF members in...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540600702206
更新日期:2006-05-01 00:00:00
abstract::Heart disease is the most common cause of morbidity and mortality in Western society and the incidence is projected to increase significantly over the next few decades as our population ages. Heart failure occurs when the heart is unable to pump blood at a rate to commensurate with tissue metabolic requirements and re...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540214312
更新日期:2002-08-01 00:00:00
abstract::Uncoupling proteins (UCPs) mediate inducible proton conductance in the mitochondrial inner membrane. Herein, we summarize our knowledge regarding UCPs in invertebrates. Since 2001, the presence of UCPs has been demonstrated in nematodes, mollusks, amphioxi, and insects. We discuss the following important issues concer...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1535
更新日期:2016-09-01 00:00:00
abstract::Iron presents us with a paradox. Without it, cells simply cannot survive because iron is an essential cofactor for many enzymes in critical biochemical pathways. However, when iron is present in excess, it can be highly cytotoxic due to its propensity to catalyze the formation of reactive oxygen radicals. To cater for...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540120450
更新日期:2001-01-01 00:00:00
abstract::In many organisms the processes of DNA replication and recombination are closely linked. For instance, in bacterial and eukaryotic systems, replication forks can become stalled or damaged, in many cases leading to the formation of double stranded breaks. Replication restart is an essential mechanism in which the recom...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540310001612237
更新日期:2003-08-01 00:00:00
abstract::Nasal-type natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy with poor survival outcomes that is relatively resistant to chemotherapy. N6-Methyladenosine (m6A) modification, the most prevalent modification of eukaryotic messenger RNA, is involved in the progression of various tumors. However, it is un...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2410
更新日期:2020-11-17 00:00:00
abstract::S-Nitrosation is rapidly emerging as a regulatory mechanism in vascular biology, with particular importance in the onset of hyperpermeability induced by pro-inflammatory agents. This review focuses on the role of endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) in regulating S-Nitrosation of adherens...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1204
更新日期:2013-10-01 00:00:00
abstract::Papillary thyroid cancer (PTC) is the most common form of thyroid cancer, comprising 80% of all thyroid malignancies. The phosphoinositide-3-kinase-protein kinase B/Akt (PI3K-PKB/Akt) pathway is a main pathway in control of cell growth. Activated mTOR and Akt are involved in the development and progression of the PTC....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2388
更新日期:2020-12-01 00:00:00