Abstract:
:In many organisms the processes of DNA replication and recombination are closely linked. For instance, in bacterial and eukaryotic systems, replication forks can become stalled or damaged, in many cases leading to the formation of double stranded breaks. Replication restart is an essential mechanism in which the recombination and repair machinery can be used to continue replication after such a catastrophic event. DNA viruses of bacteria such as lambda and T4 also rely heavily on DNA recombination to replicate their genomes and both viruses encode specialized gene products which are required for recombination-dependent replication. In this review, we examine the linkage between replication and recombination in the eukaryotic pathogen, Herpes Simplex Virus Type 1 (HSV-1). The evidence that recombination plays an intrinsic role in HSV-1 DNA replication and the infection process will be reviewed. We have recently demonstrated that HSV-1 encodes two proteins which may be analogous to the lambda phage recombination system, Red(alpha) and beta. The HSV-1 alkaline nuclease, a 5' to 3' exonuclease, and ICP8, a single stranded DNA binding protein, can carry out strand annealing reactions similar to those carried out by the lambda Red system. In addition, evidence suggesting that host recombination proteins may also be important for HSV-1 replication will be reviewed. In summary, it is likely that HSV-1 infection will require both viral and cellular proteins which participate in various pathways of recombination and that recombination-dependent replication is essential for the efficient replication of viral genomes.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Wilkinson DE,Weller SKdoi
10.1080/15216540310001612237keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
451-8issue
8eissn
1521-6543issn
1521-6551journal_volume
55pub_type
杂志文章,评审相关文献
IUBMB LIFE文献大全abstract::Interplay between the apoptosis, DNA damage, and oxidative stress as a host response to dengue viral infections remains unclear. Peripheral blood mononuclear cells (PBMCs) were isolated from 60 dengue infected patients, 20 patients with febrile illness other than dengue (OFI) and 10 non-febrile illness (NFI) patients....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1925
更新日期:2018-11-01 00:00:00
abstract::Renal ischemia/reperfusion (I/R) is an alternation of renal hemodynamics, which results in diverse postischemic responses and eventually acute kidney injury. Although renal ischemic preconditioning (IPC) is known to protect the kidney from I/R injury, the precise renoprotective mechanisms are not completely understood...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1972
更新日期:2019-03-01 00:00:00
abstract::Antibiotic resistance in Acinetobacter spp., particularly Acinetobacter baumannii, is increasing rapidly. A. baumannii possesses two intrinsic β-lactamase genes, in addition to weak permeability and efflux systems, that together confer a natural reduced susceptibility to antibiotics. In addition, numerous acquired mec...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.532
更新日期:2011-12-01 00:00:00
abstract::Interferon regulatory factors (IRFs) were originally discovered in the context of type I interferon (IFN-alpha/beta) gene induction, and subsequent studies on these transcription factors have revealed their remarkable functional diversity in regulating immune systems. Indeed, the critical involvement of IRF members in...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540600702206
更新日期:2006-05-01 00:00:00
abstract::Crude brazilin extract from Sappan wood has demonstrated strong anti tumor activity in the mouse model of human bladder carcinoma and clinical trial for intravesical therapy. Purified brazilin was confirmed the most active molecule in inhibition of bladder carcinoma T24 cells. Brazilin decreased proliferation and viab...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1357
更新日期:2015-03-01 00:00:00
abstract::Prostate specific antigen (PSA) is a serine protease that is exclusively produced in the prostate, and its detection is the only laboratory test available for screening men for prostate cancer (PC). The interpretation of the assay is difficult since it is specific for prostate tissue and cellular growth, but not for P...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.355
更新日期:2010-08-01 00:00:00
abstract::Hydrogen peroxide is a major regulator of plant programmed cell death (PCD) but little is known about the downstream genes from the H(2)O(2)-signaling network that mediate the cell death. To address this question, a novel system for studying H(2)O(2)-induced programmed cell death in Arabidopsis thaliana was used. The ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540500090793
更新日期:2005-03-01 00:00:00
abstract::In this study, we intended to determine the detailed function and mechanism of long noncoding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) in liver injury induced by sepsis. Cecal ligation and perforation (CLP) models were adopted to induce sepsis in vivo with rats, and hepatic epithelial cells L...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2230
更新日期:2020-03-01 00:00:00
abstract::Transfer RNAs require essential maturation steps to become functional. Among them, RNase P removes 5' leader sequences of pre-tRNAs. Although RNase P was long thought to occur universally as ribonucleoproteins, different types of protein-only RNase P enzymes were discovered in both eukaryotes and prokaryotes. Interest...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2062
更新日期:2019-08-01 00:00:00
abstract::The functional effect of the interaction of E2F1 and hepatitis B virus X protein (HBx) on the promoter of human p53 gene was studied using chloramphenicol acetyl transferase (CAT) assay. E2F1 activated the p53 promoter through E2F1 binding site. As previously reported, HBx repressed the p53 promoter through E-box. Whe...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540213466
更新日期:2002-06-01 00:00:00
abstract::Red blood cells of yellow-spotted river turtles (Podocnemis unifilis, Pleurodira, Chelonia, REPTILIA) have two hemoglobin (Hb) components, Hb A and Hb D. We purified the hemoglobin component homologous to amniote (reptiles, birds, and mammals) adult Hb A which comprises two identical α(A) -globin polypeptides and two ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.429
更新日期:2011-03-01 00:00:00
abstract::Worldwide, one of the most prevalent forms of chronic disease is alcoholic fatty liver, which may progress to more severe forms of liver injury including steatohepatitis, fibrosis, and cirrhosis. The molecular mechanisms by which ethanol consumption causes accumulation of hepatic lipid are multiple and complex. Chroni...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.124
更新日期:2008-12-01 00:00:00
abstract::The rat organic anion transporter 3 (rOAT3) has recently been identified as the third isoform of the OAT family. The mechanisms that regulate rOAT3's functions remain to be elucidated. rOAT3 contributes for moving a number of negatively charged organic compounds between cells and their extracellular milieu. Caveolin (...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540500104750
更新日期:2005-02-01 00:00:00
abstract::Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to this process. Its activity is modulated in a coordinated manner via a ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.411
更新日期:2011-01-01 00:00:00
abstract::S-Nitrosation is rapidly emerging as a regulatory mechanism in vascular biology, with particular importance in the onset of hyperpermeability induced by pro-inflammatory agents. This review focuses on the role of endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) in regulating S-Nitrosation of adherens...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1204
更新日期:2013-10-01 00:00:00
abstract::We propose a new hypothesis for the molecular mechanism by which neuroglobin exerts its protective effect in hypoxia-induced cell death. Our recent observation of a very rapid electron-transfer reaction between ferrous neuroglobin and ferric cytochrome c is central to this hypothesis. In contrast to previously suggest...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.35
更新日期:2008-06-01 00:00:00
abstract::Recent advances in the developmental biology, genetics and cell biology of the inner ear are guiding research to novel therapeutic modalities - a market currently estimated to be at least US Dollars 10 billion. This article highlights prospects to manipulate the mammalian hearing organ with gene and stem cell delivery...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540600913258
更新日期:2006-09-01 00:00:00
abstract::Malaria remains a worldwide health concern with an estimated quarter of a billion people infected and nearly half a million deaths annually. Malaria is caused by a parasite infection from Plasmodium strains which are transmitted from mosquitoes into the human host. Although several small molecule inhibitors have been ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2244
更新日期:2020-06-01 00:00:00
abstract::The effect of streptozotocin-induced diabetes on cholinesterases activities was studied in the retina and, for comparison, in other nervous and nonnervous tissues. Streptozotocin diabetes did not affect acetylcholinesterase activity in the retina but increased its activity in the cerebral cortex (100%) and in serum (5...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540050033140
更新日期:2000-04-01 00:00:00
abstract::Cardiovascular disease is a leading cause of morbidity and mortality. Smooth muscle cells (SMC) comprising the vascular wall can switch phenotypes from contractile to synthetic, which can promote the development of aberrant remodelling and intimal hyperplasia (IH). MicroRNA-21 (miR-21) is a short, non-coding RNA that ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1751
更新日期:2018-07-01 00:00:00
abstract::Although vitamin E has been recognized as a critical micronutrient to neuronal health for more than half a century, vitamin E transport and regulation in the brain remain a mystery. Currently, the majority of what is known about vitamin E transport has been delineated in the liver. However, clues from the pathogenesis...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1993
更新日期:2019-04-01 00:00:00
abstract::Depurinating DNA adducts formed by aromatic hydrocarbons and catechol estrogen quinones play a major role in cancer initiation. Most of these adducts depurinate instantaneously, but some guanine adducts depurinate from DNA with half-lives of hours. We report here, that after 10 h at 37 °C, reaction of estradiol-3,4-qu...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.586
更新日期:2012-02-01 00:00:00
abstract::Mutations in the breast cancer susceptibility gene BRCA1 predispose individuals to breast and ovarian cancers. Cofactor of BRCA1 (COBRA1), a novel protein, was isolated as a BRCA1-interacting protein. However, the role of COBRA1 in breast cancer is poorly understood. In this study, we demonstrate that COBRA1 mRNA was ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540410001699826
更新日期:2004-03-01 00:00:00
abstract::The invasion and chemoresistance are crucial causes of morbidity and relapse for cancer patients. Axl is implicated in the modulation of cell invasion, cancer metastasis, and chemosensitivity in human breast carcinoma cell lines. Both breast cancer cell lines and tissues displayed increased expression of Axl, and it o...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1285
更新日期:2014-07-01 00:00:00
abstract::Cartilage engineering is one challenging issue in regenerative medicine. Low oxygen tension or hypoxia inducible factor-1 (HIF-1α) gene therapy are promising strategies in the field of cartilage repair. Previously, we showed that hypoxia and its mediator HIF-1 regulate matrix genes expression (collagens and aggrecan)....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1539
更新日期:2016-09-01 00:00:00
abstract::Women with breast cancer show altered blood glucose compartmentation compared with healthy women, with lower concentrations in plasma and similar concentrations in blood cells. The goal of this paper was to study whether this pattern was the result of changes in the erythrocyte glucose transporter and, if so, to asses...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803558
更新日期:1999-11-01 00:00:00
abstract::Immune infiltration of tumors has been increasingly accepted as a prognostic factor in colon cancer. Here, we aim to develop a novel immune signature, based on estimated immune landscape from tumor transcriptomes, to predict the overall survival of patients with colon cancer. The compositions of 22 immune cell subtype...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2124
更新日期:2019-11-01 00:00:00
abstract::In this study, the impact of pancreatic cancer cell interaction with macrophages on the differentiation and function of macrophages and the behaviors of pancreatic cancer cells in vitro is evaluated. The expression of immunocompetent cell-associated markers in 22 pancreatic cancer specimens was characterized by immuno...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1336
更新日期:2014-12-01 00:00:00
abstract::Small noncoding RNAs are key controllers of cellular function, and their deregulation can lead to cancer development and metastatic evolution. This review summarizes the most important examples of small RNAs involved in human cancer and discusses their clinical use as biomarkers and drug targets for diagnosis, prognos...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.399
更新日期:2010-12-01 00:00:00
abstract::Cyclic AMP metabolism is essential for the survival of the social amoebae Dictyostelium discoideum. Three distinct adenylyl cyclases are expressed and required for the normal development of this simple eukaryote. The adenylyl cyclase expressed during aggregation, ACA, is related to the mammalian and Drosophila G prote...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540400013887
更新日期:2004-09-01 00:00:00