Abstract:
:Uncoupling proteins (UCPs) mediate inducible proton conductance in the mitochondrial inner membrane. Herein, we summarize our knowledge regarding UCPs in invertebrates. Since 2001, the presence of UCPs has been demonstrated in nematodes, mollusks, amphioxi, and insects. We discuss the following important issues concerning invertebrate UCPs: their evolutionary relationships, molecular and functional properties, and physiological impact. Evolutionary analysis indicates that the branch of vertebrate and invertebrate UCP4-5 diverged early in the evolutionary process prior to the divergence of the animal groups. Several proposed physiological roles of invertebrate UCPs are energy control, metabolic balance, and preventive action against oxidative stress. © 2016 IUBMB Life, 68(9):691-699, 2016.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Slocinska M,Barylski J,Jarmuszkiewicz Wdoi
10.1002/iub.1535subject
Has Abstractpub_date
2016-09-01 00:00:00pages
691-9issue
9eissn
1521-6543issn
1521-6551journal_volume
68pub_type
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