Plant polyphenols: how to translate their in vitro antioxidant actions to in vivo conditions.

abstract：:During the hand plate development, the processes of cell differentiation and control of cell death are relevant to ensure a correct shape of the limb. The progenitor cell pool that later will differentiate into cartilage to form the digits arises from undifferentiated mesenchymal cells beneath the apical ectodermal ri...

journal_title：IUBMB life

authors： Chimal-Monroy J,Abarca-Buis RF,Cuervo R,Díaz-Hernández M,Bustamante M,Rios-Flores JA,Romero-Suárez S,Farrera-Hernández A

更新日期：2011-10-01 00:00:00

abstract：:Implantation is a complex developmental event that is initiated by recognition and adhesion of the embryo to the endometrial epithelium. sLeX is an oligosaccharide antigen acting as the ligand of L-selectin, and is stage-specifically expressed in the endometrial epithelium. The adhesion system mediated by L-selectin a...

journal_title：IUBMB life

authors： Liu S,Zhang Y,Liu Y,Qin H,Wang X,Yan Q

更新日期：2008-07-01 00:00:00

abstract：:For 8 years, it was not understood why certain genes of plant mitochondria contain CGG (arginine) codons at positions where tryptophan codons (UGG) are present in the corresponding genes of nonplant species. Identification and sequencing of a tRNA(Trp) gene showed that it is not able to decode the CGG codon. Analysis ...

journal_title：IUBMB life

authors： Grienenberger JM

更新日期：2009-12-01 00:00:00

abstract：:We have adapted the Java Molecular Viewer (JMV) to virtual reality display environments, through a number of extensions to the Java 3D code. Phylogenetic information derived from multiple alignments (temporal information) can be overlaid onto molecule structures (spatial information). The number of sequences included ...

journal_title：IUBMB life

authors： Quon GT,Gordon P,Sensen CW

更新日期：2003-04-01 00:00:00

abstract：:The yeast Saccharomyces cerevisiae is an excellent model for gaining insights into the molecular basis of human mitochondrial disorders, particularly those resulting from impaired mitochondrial metabolism. Yeast is a very well characterized system and most of our current knowledge about mitochondrial biogenesis in hum...

journal_title：IUBMB life

authors： Barrientos A

更新日期：2003-02-01 00:00:00

abstract：:Since about 60 years a phenomenon now called permeability transition is known in mitochondria. It involves a large pore in the inner mitochondrial membrane, the permeability transition pore (PTP) whose molecular structure is still unknown. Year after year, new hypotheses have been developed how this pore could look li...

journal_title：IUBMB life

authors： Siemen D,Ziemer M

更新日期：2013-03-01 00:00:00

abstract：:To further understand the role of the three conserved Val residues in insulin, B12Val, B18Val, and A3Val, five insulin mutants-[A3Ser]insulin, [B12Thr]insulin, (desB30)[B12Ser]insulin, [B18Thr] insulin, and [B18Leu]insulin--were obtained by means of site-directed mutagenesis and their receptor-binding activities as we...

journal_title：IUBMB life

authors： Guo ZY,Tang YH,Zhang Z,Feng YM

更新日期：2001-12-01 00:00:00

abstract：:Acid fibroblast growth factor (aFGF) binds to its cell-surface receptors in a heparin-dependent manner. In an attempt to define the aFGF recognition site on fibroblast growth factor receptor 1 (FGFR1), we developed a screening strategy for identifying FGF ligands that bind to the receptor-binding region of FGF. To ret...

journal_title：IUBMB life

authors： Fan H,Liu Y,Zhou H,Wang L,Li W,Guo L,Roeske RW

更新日期：2000-06-01 00:00:00

abstract：:In most organisms, productive utilization of galactose requires the highly conserved Leloir pathway of galactose metabolism. Yet, if this metabolic pathway is perturbed due to congenital deficiencies of the three associated enzymes, or an overwhelming presence of galactose, this monosaccharide which is abundantly pres...

journal_title：IUBMB life

authors： Lai K,Elsas LJ,Wierenga KJ

更新日期：2009-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating neurodegenerative disorder that results in loss of memory and cognitive function, eventually leading to dementia. A key neuropathological event in AD is the cerebral accumulation of senile plaques formed by aggregates of amyloid-β-peptides (Aβ). Aβ results from two sequential ...

journal_title：IUBMB life

authors： Tamagno E,Guglielmotto M,Monteleone D,Vercelli A,Tabaton M

更新日期：2012-12-01 00:00:00

abstract：:Modern cell-free in vitro protein synthesis systems present powerful tools for the synthesis of isotope-labeled proteins in high yields. The production of selectively 15 N-labeled proteins from 15 N-labeled amino acids is particularly economic and yields are often sufficient to analyze the proteins very quickly by two...

journal_title：IUBMB life

authors： Ozawa K,Dixon NE,Otting G

更新日期：2005-09-01 00:00:00

abstract：:The posttranscriptional regulation of miRNAs is important for organism development. To investigate the role of miRNAs in angiogenesis, we performed a loss-of-function screening assay in human umbilical vein endothelial cells (HUVECs) and found that knockdown of 7 miRNAs (miR-95a, miR-126, miR-129, miR-137, miR-139, mi...

journal_title：IUBMB life

authors： Li YX,Liu DQ,Zheng C,Zheng SQ,Liu M,Li X,Tang H

更新日期：2011-07-01 00:00:00

abstract：:Induction of apoptosis is the target of choice for modern chemotherapeutic treatment of cancer, where lack of potent "target-specific" drugs has led to extensive research on anticancer compounds from natural sources. In our study, we have used astrakurkurone, a triterpene isolated from wild edible mushroom, Astraeus h...

journal_title：IUBMB life

authors： Dasgupta A,Dey D,Ghosh D,Lai TK,Bhuvanesh N,Dolui S,Velayutham R,Acharya K

更新日期：2019-07-01 00:00:00

abstract：:N-Acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a critical negative regulator of fibrosis development in the liver. However, its extremely short half-life in vivo greatly compromises its potential applications. Here, we report an Ac-SDKP analog peptide with d-amino acid replacement (Ac-SDD KD P). The stability of A...

journal_title：IUBMB life

authors： Zhang X,Zhou J,Zhu Y,He L,Pang Z,Wang Z,Xu C,Zhang C,Hao Q,Li W,Zhang W,Zhang Y,Li M

更新日期：2019-09-01 00:00:00

abstract：:Renal ischemia/reperfusion (I/R) is an alternation of renal hemodynamics, which results in diverse postischemic responses and eventually acute kidney injury. Although renal ischemic preconditioning (IPC) is known to protect the kidney from I/R injury, the precise renoprotective mechanisms are not completely understood...

journal_title：IUBMB life

authors： Li JR,Ou YC,Wu CC,Wang JD,Lin SY,Wang YY,Chen WY,Chen CJ

更新日期：2019-03-01 00:00:00

abstract：:Transfer RNAs require essential maturation steps to become functional. Among them, RNase P removes 5' leader sequences of pre-tRNAs. Although RNase P was long thought to occur universally as ribonucleoproteins, different types of protein-only RNase P enzymes were discovered in both eukaryotes and prokaryotes. Interest...

journal_title：IUBMB life

authors： Gobert A,Bruggeman M,Giegé P

更新日期：2019-08-01 00:00:00

abstract：:In this review we discuss the limited efficacy for current pharmacological agents used in prophylaxis and treatment of thrombosis and highlight targeted delivery of anti-thrombotic agents to fibrin, platelets, red blood cells and endothelium. ...

journal_title：IUBMB life

authors： Carnemolla R,Muzykantov VR

更新日期：2011-08-01 00:00:00

abstract：:The aggressive biological behavior of invasive and metastatic cancer is considered to be the most insidious and life-threatening aspect for breast cancer patients. It is mostly the result of changes in many molecular characteristics of tumor cells, including alterations in gene expression and the balance of proteolyti...

journal_title：IUBMB life

authors： Swellam M,Arab LR,Bushnak HA

更新日期：2007-06-01 00:00:00

abstract：:The extensive post-transcriptional modification of U2 snRNA is required for spliceosome assembly and pre-mRNA splicing in vertebrates. However, the rare modification of U2 snRNA in yeast implies a different mechanism for regulating spliceosome biogenesis in single-celled eukaryotes. To understand the evolutionary patt...

journal_title：IUBMB life

authors： Huang ZP,Zhou H,Qu LH

更新日期：2005-10-01 00:00:00

abstract：:Myocardial ischemia/reperfusion (I/R) injury greatly contributes to myocardial tissue damage in patients with coronary disease, which eventually leads to heart failure. Long noncoding RNAs (lncRNAs) have an emerging role in the process of myocardial I/R injury. Our previous work revealed the protective role of miR-374...

journal_title：IUBMB life

authors： Chen YQ,Yang X,Xu W,Yan Y,Chen XM,Huang ZQ

更新日期：2020-12-09 00:00:00

abstract：:The members of the GATA family of transcription factors have homologous zinc fingers and bind to similar sequence motifs. Recent advances in genome-wide technologies and the integration of bioinformatics data have led to a better understanding of how GATA factors regulate gene expression; GATA-factor-induced transcrip...

journal_title：IUBMB life

authors： Romano O,Miccio A

更新日期：2020-01-01 00:00:00

abstract：:Nasal-type natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy with poor survival outcomes that is relatively resistant to chemotherapy. N6-Methyladenosine (m6A) modification, the most prevalent modification of eukaryotic messenger RNA, is involved in the progression of various tumors. However, it is un...

journal_title：IUBMB life

authors： Ma H,Shen L,Yang H,Gong H,Du X,Li J

更新日期：2020-11-17 00:00:00

abstract：:It is known that that human serum albumin (HSA) and alpha-lactalbumin (LA) possess DNA-binding sites. Electrophoretically homogeneous HSA and LA containing no canonical enzymes were isolated from human sera and milk. Here we have analyzed for the first time the possibility of DNA hydrolysis by these proteins. It was s...

journal_title：IUBMB life

authors： Soboleva SE,Guschina TA,Nevinsky GA

更新日期：2018-06-01 00:00:00

abstract：:A pool of Plasmodium falciparum casein kinase 1 (PfCK1) has been shown to localize to the host red blood cell (RBC) membrane and be secreted to the extracellular medium during trophozoite stage of development. We attempted to identify mechanisms for secretion of PfCK1 and its appearance on the RBC membrane. We found t...

journal_title：IUBMB life

authors： Batty MB,Schittenhelm RB,Dorin-Semblat D,Doerig C,Garcia-Bustos JF

更新日期：2020-06-01 00:00:00

abstract：:Recent successes in identifying the genes and associated proteins underlying several familial neurodegenerative conditions have not always resulted in accounts as to why the associated patterns of neuronal damage are so specific and limited. Here, with reference to Huntington's disease, we present a general scheme to ...

journal_title：IUBMB life

authors： Mitchell IJ,Griffiths MR

更新日期：2003-06-01 00:00:00

abstract：:Specific RNAs can function as sinks for endogenous miRNAs, known as competing endogenous RNAs (ceRNAs). Here, we confirm a miR-124 mediated ceRNA crosstalk between LAMC1 and CD151 in hepatocellular carcinoma (HCC). miR-124 negatively regulates LAMC1 expression through two miRNA binding sites within its 3' untranslated...

journal_title：IUBMB life

authors： Yang ZP,Ma HS,Wang SS,Wang L,Liu T

更新日期：2017-08-01 00:00:00

abstract：:Papillary thyroid cancer (PTC) is the most common form of thyroid cancer, comprising 80% of all thyroid malignancies. The phosphoinositide-3-kinase-protein kinase B/Akt (PI3K-PKB/Akt) pathway is a main pathway in control of cell growth. Activated mTOR and Akt are involved in the development and progression of the PTC....

journal_title：IUBMB life

authors： Maruei-Milan R,Saravani M,Heidari Z,Asadi-Tarani M,Salimi S

更新日期：2020-12-01 00:00:00

abstract：:Changes in the status of DNA methylation are one of the most common molecular alterations in human neoplasia. We aimed to identify epigenetic molecular markers in serum for early detection of breast cancer. Authors analyzed retrospectively the methylation status of RARβ2 and APC genes in serum samples from 121 breast ...

journal_title：IUBMB life

authors： Swellam M,Abdelmaksoud MD,Sayed Mahmoud M,Ramadan A,Abdel-Moneem W,Hefny MM

更新日期：2015-01-01 00:00:00

abstract：:The faithful propagation of cellular signals in most organisms relies on the coordinated functions of a large family of protein kinases that share a conserved catalytic domain. The catalytic domain is a dynamic scaffold that undergoes large conformational changes upon activation. Most of these conformational changes, ...

journal_title：IUBMB life

authors： Yeung W,Ruan Z,Kannan N

更新日期：2020-06-01 00:00:00

abstract：:Our results demonstrate that open reading frame (ORF) YHR076w on chromosome VIII of Saccharomyces cerevisiae that was previously described as a hypothetical gene is expressed. This ORF is transcribed as an mRNA of approximately 1,100 nucleotides. A 41.2-kDa polypeptide and three others predicted to be modified forms o...

journal_title：IUBMB life

authors： Ramos CW,Güldener U,Klein S,Hegemann JH,Gonzalez S,Rodríguez-Medina JR

更新日期：2000-12-01 00:00:00